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  4. HSD17B6 Antibody

HSD17B6 Antibody

  • 中文名稱：
    HSD17B6兔多克隆抗體
  • 貨號：
    CSB-PA304268
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA304268(HSD17B6 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue, Primary antibody: CSB-PA304268(HSD17B6 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    HSD17B6
  • 別名：
    17-beta-HSD 6 antibody; 17-beta-HSD6 antibody; 17-beta-hydroxysteroid dehydrogenase type 6 antibody; 3 hydroxysteroid epimerase antibody; 3(alpha >beta) hydroxysteroid epimerase antibody; 3(alpha >beta) hydroxysteroid epimerasel antibody; 3-alpha->,beta-HSE antibody; 3-alpha->,beta-hydroxysteroid epimerase antibody; H17B6_HUMAN antibody; HSD17B6 antibody; HSE antibody; Hydroxysteroid (17 beta) dehydrogenase 6 antibody; Hydroxysteroid (17 beta) dehydrogenase 6 homolog (mouse) antibody; Hydroxysteroid 17 beta dehydrogenase 6 antibody; NAD+ dependent 3 alpha hydroxysteroid dehydrogenase 3 hydroxysteroid epimerase antibody; NAD+ dependent 3 alpha hydroxysteroid dehydrogenase antibody; Oxidative 3 alpha hydroxysteroid dehydrogenase antibody; Oxidative 3-alpha hydroxysteroid dehydrogenase antibody; Oxidoreductase antibody; Retinol dehydrogenase antibody; RODH antibody; SDR9C6 antibody; Short chain dehydrogenase/reductase family 9C, member 6 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human HSD17B6
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.
  • 基因功能參考文獻：
    1. No significant difference was found in genotype or allele distributions of the polymorphisms rs12529 of HSD17B5 and rs898611 of HSD17B6 between patients with PCOS and controls. PMID: 25422294
    2. the CYP11A1, CYP17A1, HSD3B2, SRD5A2, and HSD17B6 mRNA levels in metastases were significantly lower. PMID: 24244276
    3. data suggest that there is no association of HSD17B6 and HSD17B5 variants with the occurrence of polycystic ovary syndrome in the Chinese population PMID: 21039282
    4. 17beta-hydroxysteroid dehydrogenase type 6 (17betaHSD6) converts the androgen DHT to the estrogen 3beta-Adiol, and this leads to activation of the ERbeta reporter. PMID: 22114194
    5. These data suggest that polymorphisms in the HSD17B6 gene are associated with PCOS and key clinical phenotypes of the disorder. PMID: 17070195
    6. RoDH enzymes are expressed in tissues that have microsomal 3alpha-hydroxysteroid dehydrogenase/epimerase activities PMID: 17289849
    7. These replication data suggest a role for HSD17B6 in polycystic ovary syndrome PMID: 19837928

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  • 亞細胞定位：
    Microsome membrane; Peripheral membrane protein; Lumenal side. Early endosome membrane; Peripheral membrane protein; Lumenal side.
  • 蛋白家族：
    Short-chain dehydrogenases/reductases (SDR) family
  • 組織特異性：
    Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosu
  • 數據庫鏈接：

    HGNC: 23316

    OMIM: 606623

    KEGG: hsa:8630

    STRING: 9606.ENSP00000318631

    UniGene: Hs.524513



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