在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HSD17B12 Antibody

  • 中文名稱:
    HSD17B12兔多克隆抗體
  • 貨號(hào):
    CSB-PA064313
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA064313(HSD17B12 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A172 cells, A375 cells, Primary antibody: CSB-PA064313(HSD17B12 Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    HSD17B12
  • 別名:
    HSD17B12; SDR12C1; Very-long-chain 3-oxoacyl-CoA reductase; 17-beta-hydroxysteroid dehydrogenase 12; 17-beta-HSD 12; 3-ketoacyl-CoA reductase; KAR; Estradiol 17-beta-dehydrogenase 12; Short chain dehydrogenase/reductase family 12C member 1
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human HSD17B12
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.
  • 基因功能參考文獻(xiàn):
    1. The expression of HSD17B12 increased along with the severity of ovarian cancer, and the expression mimicked COX-2 expression and intensity. This further suggests the involvement of HSD17B12 in AA production, and its coexpression with COX-2 indicates a role for the enzyme in the increased prostaglandin production during ovarian cancer progression. PMID: 29324448
    2. Significant associations have been found between CpG sites and patient sex, including DNA methylation in CASP6, a gene that may respond to estradiol treatment, and in HSD17B12, which encodes a sex steroid hormone. PMID: 24058506
    3. These evidences were suggestive of a 46,XY DSD due to 17betaHSD3 deficiency. An homozygous mutation (IVS3 -1 G>C or c.326-1G>C) of the 17betaHSD3 gene was discovered. PMID: 23435447
    4. HSD17B12 overexpression is shown to be a marker of poor survival in patients with ovarian cancer; expression in the tumor and function of this enzyme facilitates ovarian cancer progression. PMID: 22903146
    5. High HSD17B12 expression is associated with neoplasms. PMID: 21409596
    6. 17beta-HSD12 is the major estrogenic 17beta-HSD responsible for the conversion of E1 to E2 in women. PMID: 16166196
    7. Location of 17beta-hydroxysteroid dehydrogenase type 12 through the human body. PMID: 16621523
    8. 17beta-HSD12 is not \related to intratumoral estradiol biosynthesis in human breast carcinoma, but is correlated with production of very long chain fatty acids and tumor progresssion. PMID: 19190350
    9. determined the activity and expression levels of known estrogenic 17beta-HSDs, namely types 1, 7 and 12 17beta-HSD in preadipocytes before and after differentiation into mature adipocytes PMID: 19429442
    10. There is no difference in catalytic properties between variants of 17beta-HSD types 7 and 12 and wild-type enzymes, while variants p.Glu77Gly and p.Lys183Arg in 17beta-HSD type 5 showed a slightly decreased activity. PMID: 19460435
    11. SREBP-1 represents one of the transcriptional regulators of human 17beta-HSD12. PMID: 19533843

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Short-chain dehydrogenases/reductases (SDR) family, 17-beta-HSD 3 subfamily
  • 組織特異性:
    Expressed in most tissues tested. Highly expressed in the ovary and mammary. Expressed in platelets.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 18646

    OMIM: 609574

    KEGG: hsa:51144

    STRING: 9606.ENSP00000278353

    UniGene: Hs.132513



主站蜘蛛池模板: 人人人妻人人澡人人爽欧美一区| 无线乱码一二三区免费看| 无码潮喷a片无码高潮视频| 一本一道久久综合狠狠老| 色综合久久久久久久久久| 欧美zozo另类特级| 国产传媒麻豆剧精品av国产 | 日韩精品专区在线影院重磅| 高清一区二区三区免费视频| 国产精品人人做人人爽| 欧美最猛黑人xxxx| 国产成人麻豆精品午夜福利在线| 久久亚洲一区二区三区舞蹈| 性色av一区二区三区人妻| 丰满少妇人妻无码| 无码成人一区二区三区| 国产成人免费97在线| 亚洲熟妇无码av不卡在线观看| 老女老肥熟国产在线视频| 黑人大荫道bbwbbb高潮潮喷| 男人和女人高潮免费网站| 国产乱码免费卡1卡二卡3| 欧美黑人性暴力猛交喷水| 大陆极品少妇内射aaaaa| 国产高清成人免费视频在线观看 | 噜噜噜亚洲色成人网站∨| 欧美成人午夜免费全部完| 色欲av永久无码精品无码| 天堂va视频一区二区| 亚洲爆乳少妇无码激情| 3d动漫精品一区二区三区| 人妻av无码系列专区移动可看| 国产区在线观看成人精品| 精品人妻少妇一区二区| 色多多性虎精品无码av| 国产乱子伦精品视频| 久久人人97超碰国产亚洲人| 久久人人爽人人爽爽久久小说| 激情内射亚洲一区二区三区| 伊人久久大香线蕉av一区二区| 精品国产一区二区三区av片 |