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HSCB Antibody, HRP conjugated

  • 中文名稱：
    HSCB兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA816893LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) HSCB Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    HSCB
  • 別名：
    AI325508 antibody; AW049829 antibody; dJ366L4.2 antibody; DnaJ (Hsp40) homolog, subfamily C member 20 antibody; DnaJ homolog subfamily C member 20 antibody; DNAJC20 antibody; Hsc20 antibody; HSC20_HUMAN antibody; hscB antibody; HscB iron sulfur cluster co chaperone homolog antibody; Iron sulfur cluster co chaperone protein HscB mitochondrial antibody; Iron-sulfur cluster co-chaperone protein HscB antibody; J type co chaperone HSC20 antibody; JAC1 antibody; mitochondrial antibody; RGD1311005 antibody; RP3-366L4.2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Iron-sulfur cluster co-chaperone protein HscB, mitochondrial protein (30-235AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as a co-chaperone in iron-sulfur cluster assembly in both mitochondria and the cytoplasm. Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain. Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20. Also mediates complex formation between components of the cytosolic iron-sulfur biogenesis pathway and the CIA targeting complex composed of CIAO1, DIPK1B/FAM69B and MMS19 by binding directly to the scaffold protein ISCU and to CIAO1. This facilitates iron-sulfur cluster insertion into a number of cytoplasmic and nuclear proteins including POLD1, ELP3, DPYD and PPAT.
  • 基因功能參考文獻：
    1. Nfu is shown to bind to both chaperone proteins with binding affinities similar to those observed for IscU binding to the homologous HSPA9 and Hsc20, while Nfu can also stimulate the ATPase activity of HSPA9 PMID: 29211945
    2. The delivery of assembled Fe-S clusters to recipient proteins is a crucial step in the biogenesis of Fe-S proteins; review focuses on recent insights into the molecular mechanism of amino acid motif recognition and discrimination by the co-chaperone HSC20 and finds co-chaperone HSC20 binds to LYR motifs present in Fe-S recipient proteins or their binding partners. [Review] PMID: 27714045
    3. the crucial role of HSC20 in the assembly of the mitochondrial respiratory chain, is reported. PMID: 28380382
    4. NFS1 binds preferentially to the D-state of ISCU while mtHSP70 binds preferentially to the D-state of ISCU and HSC20 binds preferentially to the S-state of ISCU. PMID: 23940031
    5. A cysteine-rich N-terminal domain, which clearly distinguishes hHSC20 from the specialized DnaJ type III proteins of fungi and most bacteria, was found to be important for the integrity and function of the human co-chaperone. PMID: 20668094
    6. structural analysis of human J-type co-chaperone HscB reveals a tetracysteine metal-binding domain PMID: 18713742

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  • 亞細胞定位：
    [Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic]: Cytoplasm.; [Iron-sulfur cluster co-chaperone protein HscB, mitochondrial]: Mitochondrion.
  • 蛋白家族：
    HscB family
  • 組織特異性：
    Expressed in lung, brain, stomach, spleen, ovary, testis, liver, muscle and heart.
  • 數據庫鏈接：

    HGNC: 28913

    OMIM: 608142

    KEGG: hsa:150274

    STRING: 9606.ENSP00000216027

    UniGene: Hs.632780



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