在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HPN Antibody

  • 中文名稱:
    HPN兔多克隆抗體
  • 貨號:
    CSB-PA010704GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    HPN
  • 別名:
    HPN; TMPRSS1; Serine protease hepsin; Transmembrane protease serine 1
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Human Hpn
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Purified Protein A
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL. Plays a role in cell growth and maintenance of cell morphology. Plays a role in the proteolytic processing of ACE2. Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization.
  • 基因功能參考文獻:
    1. Study showed was that Hepsin was downregulated in 78% of gastric cancer. Its high expression seems to predict poor prognosis. These results predicted that hepsin protein expression was one of the significant and independent prognostic factors for overall survival of Gastric Cancer. PMID: 27841306
    2. Genetic variation in/near the gene encoding for hepsin protein may influence risk of bipolar disorder and (at least for the rs62122114-A allele) may have functional impact (i.e. differential expression) as evidenced by serum HPN protein expression. PMID: 28886448
    3. significant negative association was found between hepsin expression in endometrial carcinoma cases regarding the grade and the size of tumors as well as myometrial invasion PMID: 26990747
    4. These data demonstrate that the membrane-bound serine protease hepsin is the enzyme responsible for the physiological cleavage of uromodulin. PMID: 26673890
    5. The Hepsin pathway acts in concert with Wnt pathway to promote prostate cancer progression. PMID: 26139199
    6. Low expression levels of hepsin and TMPRSS3 are associated with poor breast cancer survival PMID: 26014348
    7. Hepsin suppressed CDK11p58 internal ribosome entry site activity in prostate cancer cells by modulating UNR expression and eIF-2alpha phosphorylation. PMID: 25576733
    8. The results of this study suggest that, in Korean men, some polymorphisms in the HPN gene might be associated with the risk of developing prostate cancer. PMID: 22665141
    9. hepsin expression is frequently up-regulated in breast cancer tissues, which is associated with tumor growth and progression PMID: 21383634
    10. These findings suggest that the MSP/RON signaling pathway may be regulated by hepsin in tissue homeostasis and in disease pathologies, such as in cancer and immune disorders. PMID: 21875933
    11. Elevated levels of hepsin interfere with cell adhesion and viability in the background of prostate cancer as well as other tissue types, the details of which depend on the microenvironment provided. PMID: 21750652
    12. Hepsin activity was inhibited by anthralin and increased by resveratrol. PMID: 20673210
    13. Germline genetic variation of HPN does not seem to contribute to risk of prostate cancer or prognosis. PMID: 20166135
    14. Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor. PMID: 19911255
    15. Hepsin and maspin are inversely expressed in laser capture microdissectioned prostate cancer PMID: 12629351
    16. Hepsin is functionally linked to hepatocyte growth factor/MET pathway, which may contribute to prostate cancer progression. PMID: 15792801
    17. A major 11-locus haplotype is significantly associated with prostate cancer, which provides further support that HPN is a potentially important candidate gene involved in prostate cancer susceptibility. PMID: 16783571
    18. the ability of hepsin to efficiently activate pro-uPA suggests that it may initiate plasmin-mediated proteolytic pathways at the tumor/stroma interface that lead to basement membrane disruption and tumor progression PMID: 16908524
    19. Our findings suggest that the balance between hepsin and its inhibitor, HAI-2, may have prognostic value in RCC. PMID: 17309599
    20. We analyzed all the common variations using tag SNP in the HPN and LTBP4 genes for association with IA in 390 patients and 642 controls in the Dutch population. PMID: 18487557
    21. Hepsin showed potential inhibitory effects mediated by the induction of 14-3-3sigma expression which leads to both cell cycle arrest at the G2/M phase PMID: 18698500
    22. Ln-332 may be one mechanism by which hepsin promotes prostate tumor progression and metastasis, possibly by up-regulating prostate cancer cell motility. PMID: 18784072

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type II membrane protein.
  • 蛋白家族:
    Peptidase S1 family
  • 組織特異性:
    Detected in liver and kidney.
  • 數據庫鏈接:

    HGNC: 5155

    OMIM: 142440

    KEGG: hsa:3249

    STRING: 9606.ENSP00000262626

    UniGene: Hs.182385



主站蜘蛛池模板: 亚在线观看免费视频入口| 新版天堂资源中文8在线| 精品一区二区三区无码免费直播| 精品熟人妻一区二区三区四区不卡 | 久久婷婷国产剧情内射白浆| 亚洲欧美国产制服图片区| 国产精品无码无片在线观看| 日本在线观看| 自拍校园亚洲欧美另类| 波多野成人无码精品电影| 在线天堂资源www中文| 两个黑人大战嫩白金发美女| 无遮挡又爽又刺激的视频| 亚洲乱码卡一卡二卡| 97久久精品人人槡人妻人| 试看120分钟做受小视频| 欧美日韩人人模人人爽人人喊| 国产欧美日韩视频一区二区三区 | 人人妻人人爽人人做夜欢视频 | 免费人妻精品一区二区三区| 超碰国产天天做天天爽| 国产激情电影综合在线看| 欧美国产一区二区三区激情无套| 国产性猛交普通话对白| 日本一区二区三区不卡免费| 少妇私密推油呻吟在线播放| 精品无码人妻一区二区三区不卡| 超清无码av最大网站| 国精产品48x国精产品| 日韩人妻无码精品久久久不卡| 吃奶呻吟打开双腿做受在线视频| 国产精品国产对白熟妇| 色诱视频在线观看| 亚洲最大无码中文字幕| 国产av福利第一精品| 蜜桃mv在线播放免费观看视频| 亚洲精品久久无码av片| 亚洲成av人片不卡无码久久| 老熟女老太婆爽| 天堂网在线.www天堂在线资源| 亚洲精品制服丝袜四区|