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HPD Antibody

  • 中文名稱：
    HPD兔多克隆抗體
  • 貨號：
    CSB-PA010698LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: HPD antibody at 4.5µg/ml
      Lane 1: Mouse kidney tissue
      Lane 2: Mouse liver tissue
      Lane 3: HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 45, 41 kDa
      Observed band size: 45 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA010698LA01HU at dilution of 1:20
    • Immunofluorescent analysis of HepG2 cells using CSB-PA010698LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：

    Inoculating a rabbit with recombinant human 4-hydroxyphenylpyruvate dioxygenase protein (2-393aa), extracting antibodies from the rabbit serum, and then purifying the collected antibodies via protein G affinity chromatography. The resulting antibody is the HPD polyclonal antibody. It contains minimal impurities, and its purity exceeds 95%.

    This HPD polyclonal is capable of recognizing and binding to HPD protein from human and mouse samples. It has been validated in various experimental settings, including ELISA, WB, IHC, and IF, and can be used for the detection of levels, determination of presence and size, and analysis of the distribution of the HPD protein.

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) HPD Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    HPD
  • 別名：
    4 HPPD antibody; 4 hydroxyphenylpyruvate dioxygenase antibody; 4 hydroxyphenylpyruvic acid oxidase antibody; 4-hydroxyphenylpyruvate dioxygenase antibody; 4-hydroxyphenylpyruvic acid oxidase antibody; 4HPPD antibody; GLOD3 antibody; glyoxalase domain containing 3 antibody; HPD antibody; HPPD_HUMAN antibody; HPPDase antibody; PPD antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human 4-hydroxyphenylpyruvate dioxygenase protein (2-393AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，HPD Antibody (CSB-PA010698LA01HU)，的標記方式是Non-conjugated。對于HPD Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應用
    HRP CSB-PA010698LB01HU HPD Antibody, HRP conjugated ELISA
    FITC CSB-PA010698LC01HU HPD Antibody, FITC conjugated
    Biotin CSB-PA010698LD01HU HPD Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:10-1:100
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Key enzyme in the degradation of tyrosine.
  • 基因功能參考文獻：
    1. The mutagenesis and structural simulation studies demonstrate the critical and unique role of each ligand in the function of HPPD, and which correlates with their respective co-ordination position. PMID: 26936969
    2. 4-hydroxyphenylpyruvate dioxygenase gene mutation is associated with Hawkinsinuria. PMID: 26226126
    3. Glutamine375 has a critical role for 4-HPPD in orientating the tail and ensuring the conformation of the terminal alpha-helix of the enzyme to maintain the integrity of the active site for biocatalysis. PMID: 23950902
    4. The IIe335Met allele is equivalent to a null mutation while the Asn241Ser allele results in a partially active enzyme with an uncoupled turnover causing elevated haykinin in urine. PMID: 17560158
  • 相關疾病：
    Tyrosinemia 3 (TYRSN3); Hawkinsinuria (HAWK)
  • 蛋白家族：
    4HPPD family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 5147

    OMIM: 140350

    KEGG: hsa:3242

    STRING: 9606.ENSP00000289004

    UniGene: Hs.2899



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