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HNRNPLL Antibody

  • 中文名稱：
    HNRNPLL兔多克隆抗體
  • 貨號：
    CSB-PA002952
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of COLO205 cells using hnRNP LL Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    HNRNPLL
  • 別名：
    BLOCK24 antibody; Heterogeneous nuclear ribonucleoprotein L like antibody; Heterogeneous nuclear ribonucleoprotein L-like antibody; HNRLL_HUMAN antibody; hnRNPLL antibody; HNRPLL antibody; SRRF antibody; Stromal RNA regulating factor antibody; Stromal RNA-regulating factor antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human hnRNP LL.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC.
  • 基因功能參考文獻：
    1. Loss-of-function mutation of hnRNPLL disrupts peripheral T cell accumulation even in the absence of CD45 protein, indicating that hnRNPLL acts through an independent mechanism to promote peripheral T cell longevity. PMID: 20505149
    2. Participation of SRRF (Stromal RNA Regulating Factor) isoforms in post-transcriptional events in bone marrow stromal cells; an important role in regulation of the RNA expression that directs the bone marrow stromal cells differentiation pathway PMID: 15256261
    3. identification of heterogeneous ribonucleoprotein L-like (hnRNPLL) as a critical inducible regulator of CD45 alternative splicing PMID: 18669861
    4. These data establish that hnRNP LL plays a critical and unique role in the signal-induced regulation of CD45 and demonstrate the utility of cell-based screens for the identification of novel splicing regulatory factors. PMID: 18719244
  • 組織特異性：
    Widely expressed. Detected in bone marrow stroma cells, skeletal muscle, heart, placenta, pancreas, kidney and lung.
  • 數據庫鏈接：

    HGNC: 25127

    OMIM: 611208

    KEGG: hsa:92906

    STRING: 9606.ENSP00000387088

    UniGene: Hs.445497



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