在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HNRNPL Antibody, Biotin conjugated

  • 中文名稱:
    HNRNPL兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA010612LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) HNRNPL Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    HNRNPL
  • 別名:
    D830027H13Rik antibody; FLJ35509 antibody; Heterogeneous nuclear ribonucleoprotein L antibody; hnRNP L antibody; hnRNP-L antibody; Hnrnpl antibody; hnRPL antibody; HNRPL_HUMAN antibody; P/OKcl.14 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Heterogeneous nuclear ribonucleoprotein L protein (89-335AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter.
  • 基因功能參考文獻:
    1. High expression of HnRNP L is associated with oral squamous cell carcinoma. PMID: 27808105
    2. uc.345 could upregulate the hnRNPL expression and that inhibition of (hnRNPL) dampens the tumorigenesis capability of uc.345. PMID: 27689400
    3. HnRNP L is a novel regulator of HPV16 RNA processing.HnRNP L controls HPV16 RNA polyadenylation and splicing in an Akt kinase-dependent manner. PMID: 28934469
    4. Translation of VEGFA mRNA in myeloid cells is dictated by a bi-directional interaction between miR-574-3p, a CA-rich microRNA, and hnRNP L. In normoxia, miR-574-3p, acting as a decoy, binds cytoplasmic hnRNP L and prevents its binding to the CARE and stimulation of VEGFA mRNA translation, simultaneously permitting miR-297-mediated translational silencing. PMID: 28520992
    5. High HNRNPL expression is associated with prostate cancer. PMID: 28038443
    6. hnRNP-L contributes to poor prognosis and tumor progression of BC by inhibiting the intrinsic apoptotic signaling and enhancing MAPK signaling pathways PMID: 28088793
    7. hnRNP L inhibits proximal 5'SS but promotes two consecutive distal 5'SS splicing, antagonizing SRSF1 roles in KLF6 pre-mRNA splicing. PMID: 28119102
    8. HNRNPL acts as the adaptor to combine the two substructures and form the intact Sam68 nuclear body through the interaction of two sets of RNA recognition motifs with the putative architectural RNA in the respective substructures. PMID: 27377249
    9. hnRNP L controls inclusion of a broad spectrum of alternative cassette exons in T cells. PMID: 26437669
    10. The study presents the structural characterization of the RNA recognition motif domains of hnRNP-L and demonstrate their function in repressing exon 4 of SLC2A2. PMID: 26051023
    11. Data suggest that incorporation of 3(S)-methyl-beta-alanine into a short alpha-helical region of nucleic acid binding domain of hnRNP LL significantly stabilizes helix without affecting its DNA binding properties. PMID: 25982410
    12. Our results reveal that hnRNP L is a new regulator for CD44 V10 exon splicing. PMID: 25623890
    13. hnRNP K and hnRNP L may serve as A1CF-like cofactors in AID-mediated class switch recombination and somatic hypermutation PMID: 25902538
    14. Results show that HNRNPL represses splicing when bound to intronic regions upstream of alternative exons, and in contrast, activates splicing when bound to the downstream intron. PMID: 24526010
    15. hnRNP L is a potential biomarker for the diagnosis of HBV-HCC and show that hnRNP L contributes to HCC progression. PMID: 24125732
    16. HnRNP L and hnRNP LL antagonistically modulate PTB-mediated splicing suppression of CHRNA1 pre-mRNA. PMID: 24121633
    17. THRIL has a role in regulating TNFalpha expression through its interaction with hnRNPL PMID: 24371310
    18. Data show that alternative exons with weak 5' splice site sequences specifically show a strong correlation between hnRNP L binding and hnRNP L-dependent splicing regulation. PMID: 24164894
    19. functional component of hnRNP LL is consistent with the fact that the full-length hnRNP LL has a greater silencing activity than hnRNP L PMID: 23646903
    20. Induction of caspase-9b expression is due to activation of hnRNP L via phosphorylation to compete/inhibit hnRNP U association with exon 3 of Casp9 mRNA. PMID: 23396972
    21. hnRNP L represses CD45 exon 4 by recruiting hnRNP A1 to a sequence upstream of the 5' splice site PMID: 23394998
    22. HnRNPL is a key factor involved in the spermatogenesis by functional proteomic studies of azoospermia patients with sertoli cell only syndrome. PMID: 22245417
    23. Constitutive deletion of splicing factor hnRNP L impedes early embryonic development of transgenic mice. PMID: 22523384
    24. NSP 5a3a's novel interaction with B23 and ribonuclear protein hnRNP-L implicates NSP 5a3a in cellular processes such as ribosome biogenesis and rRNA transcription . PMID: 20237420
    25. Hypoxia induces translocation of nuclear hnRNP L to the cytoplasm, which markedly increases hnRNP L binding to VEGFA mRNA thereby inhibiting miRNA activity. PMID: 21343907
    26. hnRNP L represses splicing by preventing 5' splice site recognition of the U1 snRNP. PMID: 19946215
    27. The binding of hnRNP L to an exon represses strong splice sites but enhances weak splice sites. PMID: 20122404
    28. identified hnRNP L as a novel Sam68-interacting protein partner. PMID: 19912651
    29. AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter PMID: 11809897
    30. HnRNP L may be involved in the regulation of many other genes containing CA repeats or A/C-rich enhancers. PMID: 12447348
    31. hnRNP L plays roles in enhancing stability, polyadenylation, and nucleocytoplasmic export; it does so by directly recruiting to intronless pre-mRNA processing enhancer (PPE) element-containing RNAs cofactors normally recruited to intron-containing RNAs. PMID: 16024770
    32. 11 target genes of hnRNP L were describes. PMID: 18073345
    33. hnRNP L is an essential component of CaMKIV-regulated alternative splicing through CA repeats, with its phosphorylation likely playing a critical role. PMID: 19017650
    34. These results strongly demonstrate the functional requirement of cellular hnRNP L for the HCV internal ribosome entry site activity. PMID: 19061868
    35. hnRNP L cross-regulates inclusion of an analogous poison exon in the hnRNP L-like pre-mRNA, which explains the reciprocal expression of the two closely related hnRNP L proteins. PMID: 19124611
    36. CA repeats in the 3'UTR of bcl-2 mRNA interact with hnRNP L in vitro and in vivo; this physical association is partially involved in the decay of bcl-2 mRNA. PMID: 19298794
    37. Identification of a novel, higher eukaryotic specific subunit, heterogeneous nuclear ribonucleoprotein L (HnRNP-L)required for lysine methylation in vivo. PMID: 19332550
    38. confirm the interactions of eEF1A1, p54(nrb), hnRNP-L, GAPDH and ASF/SF2 with the right terminal stem-loop domain of HDV genomic RNA in vitro PMID: 19464723

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus, nucleoplasm. Cytoplasm.
  • 數據庫鏈接:

    HGNC: 5045

    OMIM: 164021

    KEGG: hsa:3191

    STRING: 9606.ENSP00000221419

    UniGene: Hs.644906



主站蜘蛛池模板: 男女性爽大片视频免费看| 亚洲成a人片77777kkkk| 日本亲近相奷中文字幕| 99热亚洲色精品国产88| 国产av无码专区亚洲aⅴ| 天堂资源最新在线| 久久精品a亚洲国产v高清不卡| 无码熟熟妇丰满人妻啪啪| 亚洲v欧美v日韩v国产v| 国产xxxx视频在线观看| 国产精品无码久久久久| 中文字幕v亚洲日本在线| 99大香伊乱码一区二区| 久久婷婷五月综合色国产| 亚洲精品tv久久久久久久久久| 亚洲一码二码三码精华液| 亚洲精品久久久久一区二区三区| 欧美与黑人午夜性猛交久久久| 人成午夜大片免费视频77777| 亚洲日韩欧美国产另类综合| 亚洲精品av无码喷奶水网站| 真人性囗交69视频| 丁香五月激情综合色婷婷| 无码人妻少妇久久中文字幕蜜桃 | 2020最新无码国产在线观看| 一边啪啪一边呻吟av夜夜嗨| 国产成人精品综合久久久| 四虎国产精品永久在线国在线| 国产高清精品软件丝瓜软件| 成年入口无限观看免费完整大片| 精品亚洲一区二区三区在线观看| 九九久久精品免费观看| 日本肉体裸xxxxbbbb| 亚洲午夜未满十八勿入网站| 成年午夜性影院免费观看| 狠狠色色综合站| 丰满熟女人妻一区二区三| 尤物yw193无码点击进入| 亚洲性色av性色在线观看| 欧美搡bbbbb搡bbbbb| 窝窝影院午夜看片|