HMO1 Antibody
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中文名稱:HMO1 Antibody
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貨號:CSB-PA199576XA01SVG
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規格:¥880
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圖片:
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其他:
產品詳情
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產品名稱:Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) HMO1 Polyclonal antibody
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Uniprot No.:
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基因名:HMO1
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別名:High mobility group protein 1 (High spontaneous mutagenesis protein 2) HMO1 HSM2 YDR174W YD9395.07
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宿主:Rabbit
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反應種屬:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
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免疫原:Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) HMO1 protein (1-246aa)
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免疫原種屬:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
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標記方式:Non-conjugated
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克隆類型:Polyclonal
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抗體亞型:IgG
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純化方式:>95%, Protein G purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式:Liquid
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應用范圍:ELISA, WB
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推薦稀釋比:
Application Recommended Dilution WB 1:500-1:5000 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途:For Research Use Only. Not for use in diagnostic or therapeutic procedures.
靶點詳情
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功能:DNA-binding protein that is probably part of the rDNA transcription apparatus. Acts synergetically with the RPA49 subunit of RNA polymerase I during rDNA transcription. May participate in mutagenesis control.
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基因功能參考文獻:
- Persistent induction of DNA double-strand breaks or mTORC1 inhibition by rapamycin results in reduced levels of HMO1 mRNA, but only in the presence of Tor1p. This down-regulation is accompanied by eviction of Ifh1p and recruitment of Crf1p, followed by concerted dissociation of Hmo1p and Tor1p. PMID: 28701348
- HMO1 appears to have evolved a unique linker histone-like function involving the ability to stabilize both conventional nucleosome arrays as well as DNA regions characterized by low nucleosome density or the presence of noncanonical nucleosomes. PMID: 27903656
- studied the genome-wide binding patterns of Nhp6, Hmo1 and the SWI/SNF complex, finding that most of gene promoters presenting high occupancy of this complex also display high enrichment of these HMG proteins. PMID: 28089519
- Hmo1p functions to control DNA end resection, thereby preventing error-prone A-EJ repair and directing repairs towards classical NHEJ. The very low efficiency of DSB repair in kuDeltahmo1Delta cells further suggests that excessive DNA resection is inhibitory for A-EJ. PMID: 28336179
- Both HMG boxes in Hmo1 are essential for DNA binding PMID: 25410521
- Saccharomyces cerevisiae HMGB protein HMO1 stabilizes chromatin as evidenced by faster chromatin remodeling in its absence. PMID: 25979266
- Hmo1's C-terminal tail, implicated in chromatin bending, facilitates the formation of catenations/hemicatenations and mediates the roles of Hmo1 in DNA damage tolerance pathway choice and sister chromatid junction formation. PMID: 24473148
- Aurhors propose that Hmo1 has acquired species-specific functions and shares with UBF1 and Schizosaccharomyces pombe-Hmo1 an ancestral function to stimulate rDNA transcription. PMID: 24021628
- The HMO1 promoter is regulated by TOR signaling through an HMO1- and Fhl1-dependent mechanism. PMID: 21924331
- Hmo1 plays a novel role in transcription by forming the 5'-boundary (instead of -1 nucleosome on many other promoters) for the pre-initiation complex assembly zone on a subset of ribosomal protein genes promoters. PMID: 21288884
- the combined activity of the Hmo 1 and the Ixr1 proteins provides efficient correction of both repair and replication errors. PMID: 20734765
- The C-terminal domain of yeast high mobility group protein HMO1 mediates lateral protein accretion and in-phase DNA bending PMID: 20402481
- HMO1 contains two functional DNA binding domains PMID: 15507436
- Taken together, our data suggest that interactions between box A and the C-terminal tail induce a conformation that is required for DNA bending. PMID: 16533046
- Hmo1 has a role in coordinating the transcription of rRNA and RP genes. PMID: 16612005
- Data show that Hmo1 is directly involved in coordinating rDNA transcription by Pol I and ribosomal protein gene expression by Pol II under the control of the TOR pathway. PMID: 17875934
- HMO1 may participate in start site selection of a subset of class II genes presumably via its interaction with TFIID. PMID: 18187511
- Data demonstrate that actively transcribed rRNA genes are largely devoid of histone molecules, but instead associate with the high-mobility group protein Hmo1. PMID: 18451108
- Data indicate that Top2 is dispensable for transcription and that Hmo1 and Top2 bind in the proximity of genes transcribed in S phase suppressing chromosome fragility at the mitosis-G1 transition. PMID: 19737516
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亞細胞定位:Nucleus, nucleolus. Note=Colocalizes with FOB1.
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數據庫鏈接:
KEGG: sce:YDR174W
STRING: 4932.YDR174W
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