在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. HMHA1 Antibody

HMHA1 Antibody

  • 中文名稱：
    HMHA1兔多克隆抗體
  • 貨號：
    CSB-PA010579GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    HLA HA1 antibody; hmha1 antibody; HMHA1_HUMAN antibody; KIAA0223 antibody; mHag HA-1 antibody; Minor histocompatibility antigen HA 1 antibody; Minor histocompatibility antigen HA-1 antibody; Minor histocompatibility protein HA 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human HMHA1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity.; Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL.
  • 基因功能參考文獻：
    1. ArhGAP45 acts as a Rac-GAP contributing to the balance between formation and disruption of endothelial junctions, which is required for the dynamic regulation of vascular permeability. PMID: 29174013
    2. HMHA1 significantly promotes melanoma cells proliferation, invasion and migration, and prevents cell apoptosis. PMID: 28939173
    3. Placental HA-1 expression is regulated by oxygen and is increased in the syncytial nuclear aggregates and syncytiotrophoblast of preeclamptic as compared to control placentas. PMID: 26095815
    4. study shows that HMHA1 acts as a RhoGAP to regulate GTPase activity, cytoskeletal remodeling and cell spreading, which are crucial functions in normal hematopoietic and cancer cells PMID: 24086303
    5. the information on allele and genotype frequencies of HA-1 and HA-2 in a Taiwanese population PMID: 20509834
    6. The intensity of the tetramer-staining of the HA-1/HA-2-specific cytotoxic T cells strongly correlates with their capability to recognize mHag positive target cells. PMID: 11920221
    7. HA-1-specific CTLs restricted by nonself HLA-A2 molecules can be generated in an HLA-A2-mismatched setting. PMID: 12091347
    8. In bone marrow transplant recipients and their genetically HLA-identical siblings, the presence of different alleles of two minor histocompatibility antigen genes is studied. PMID: 15350465
    9. Pre-existing HA-1-specific T cells are observed in cord blood samples. Both circulating and ex vivo-generated HA-1-specific T cells show specific and hematopoietic restricted lysis of HLA-A2+/HA-1+ target cells, including leukemic cells. PMID: 15498856
    10. the incidence of the HA-1 168His allele is significantly lower in Sjogren's syndrome patients than in controls PMID: 15593299
    11. There was no difference in acute rejection rates between the HA-1-matched and -mismatched groups in kidney transplantation. PMID: 17580157
    12. targeting mHags encoded not only by HMHA1, whose aberrant expression in solid tumors has been reported, but also BCL2A1 may bring about beneficial selective graft-versus-tumor effects PMID: 18414982
    13. study examined antigenic presentation & T-cell recognition of HA-1, a prototypic autosomal mHag derived from single nucleotide dimorphism (HA-1(H) versus HA-1(R)) in the HMHA1 gene; results define the molecular mechanisms governing immunogenicity of HA-1 PMID: 19234124

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Cell projection, ruffle membrane.
  • 組織特異性：
    Expressed on cells of the hematopoietic lineage. Detected in dendritic cells and epidermal Langerhans cells. Expressed in peripheral blood mononuclear cells, in all leukemia/lymphoma cell lines. Detected also in some solid tumors and tissues such as cance
  • 數據庫鏈接：

    HGNC: 17102

    OMIM: 601155

    KEGG: hsa:23526

    STRING: 9606.ENSP00000316772

    UniGene: Hs.465521



主站蜘蛛池模板： 在线综合亚洲欧美日韩| 成人欧美一区二区三区的电影 | 激情综合亚洲色婷婷五月| 亚洲无线码一区二区三区| 亚洲爆乳成av人在线蜜芽| 午夜亚洲国产理论片中文| 欧美婷婷六月丁香综合色| 亚洲色www永久网站| 亚洲色欲一区二区三区在线观看| 日韩 无码 偷拍 中文字幕| 欧洲亚洲国产成人综合色婷婷| 中文午夜人妻无码看片| 99久久人妻无码精品系列蜜桃| 日日澡夜夜澡人人高潮| 影音先锋在线亚洲网站| 少妇呻吟白浆高潮啪啪69| 国产无遮挡又黄又爽在线观看| 国精产品一区一区三区有限公司杨| 国产清纯白嫩初高生在线观看 | 2019午夜福利不卡片在线| 精品国产天线2019| 日本乱子人伦在线视频| 亚洲色成人网站www永久蜜芽| 99热网址最新获取域名| 免费无码毛片一区二区三区a片| 久久久噜噜噜久久中文字幕色伊伊 | 女人19水真多免费毛片| 熟妇人妻av中文字幕老熟妇| 国产情侣真实露脸在线| 国产成人综合在线女婷五月99播放| 中文字幕v亚洲日本在线电影| 久久久久蜜桃精品成人片公司| 亚洲精品色在线网站| 国产a国产片国产| 国产精品真实灌醉女在线播放| 国产精品久久久久高潮| 婷婷四房综合激情五月| 午夜福利影院私人爽爽| 伊人久久亚洲综合影院首页 | 国产精品1区2区3区在线观看| 国内精品乱码卡一卡2卡三卡新区|