在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HMGN5 Antibody

  • 中文名稱:
    HMGN5兔多克隆抗體
  • 貨號:
    CSB-PA877299
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA877299(HMGN5 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    HMGN5
  • 別名:
    High mobility group nucleosome binding domain 5 antibody; High mobility group nucleosome-binding domain-containing protein 5 antibody; Hmgn5 antibody; HMGN5_HUMAN antibody; NBP 45 antibody; NSBP 1 antibody; NSBP1 antibody; Nucleosomal binding protein 1 antibody; Nucleosome binding protein 1 antibody; Nucleosome-binding protein 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human HMGN5
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction.
  • 基因功能參考文獻:
    1. Findings suggest that a miR-140-5p/HMGN5/autophagy regulatory loop plays a critical role in chemoresistance in osteosarcoma. In conclusion, our data elucidated that miR-140-5p promoted autophagy mediated by HMGN5 and sensitized osteosarcoma cells to chemotherapy. PMID: 28341864
    2. High HMGN5 expression is associated with osteosarcoma invasion. PMID: 28627703
    3. We observed decreased miR-409-3p expression in glioma, and overexpression of miR-409-3p repressed glioma cell invasion and proliferation by targeting HMGN5, an oncogene associated with glioma PMID: 28109076
    4. HMGN5 regulated the expression of multidrug resistance 1, cyclin B1, and Bcl-2. PMID: 28914995
    5. NSBP1 was highly expressed in NSCLC cells. NSBP1 siRNA knockdown suppressed NSCLC cell proliferation and invasion. miR326 has a putative binding site in the NSBP1 3'UTR. NSBP1 overexpression abolished miR326 inhibition of cyclin B1 and MMP9 expression. PMID: 26548724
    6. HMGN5 overexpression is correlated with advanced pathological grade and poorer prognosis in meningiomas PMID: 26315299
    7. Decreased miR-340 expression may contribute to the development and progression of prostate cancer through a mechanism that involves HMGN5. PMID: 26394192
    8. Our data first time identified miR-186 as the upstream regulator of NSBP1 PMID: 26290438
    9. High HMGN5 expression is associated with urothelial bladder cancer. PMID: 25796505
    10. HMGN5 is an oncogene and plays an important role in prostate cancer tumorigenesis and progression. the level of HMGN5 may be used as a biomarker to predict the patients that would benefit from gemcitabine treatment. PMID: 25572120
    11. HMGN5 plays an oncogenic role in human breast cancer by inhibiting cell proliferation and invasion, and activating apoptosis, which could be exploited as a target for therapy in human breast cancer. PMID: 25315189
    12. HMGN5 knockdown sensitizes prostate cancer cells to ionizing radiation PMID: 25307178
    13. HMGN5 plays oncogenic role in osteosarcoma by promoting cell proliferation and invasion, and could be exploited as a target for therapy in osteosarcoma. PMID: 24687550
    14. HMGN5 is a critical factor in the development of chemoresistance through regulating autophagy, and it offers a novel target for improving osteosarcoma therapy. PMID: 24664583
    15. Data indicate that cells lacking either high mobility group protein N5 (HMGN5) and lamina-associated polypeptide 2alpha (LAP2alpha) showed that loss of either protein affects the genome-wide distribution of the remaining partner. PMID: 23673662
    16. HMGN5 silencing to significantly inhibit A549 and H1299 cell proliferation. PMID: 22994738
    17. HMGN5 may be a potential molecular target with therapeutic relevance for the treatment of prostate cancer. PMID: 22504871
    18. NSBP1 plays oncogenic role in clear cell renal cell carcinoma (ccRCC) by promoting cell proliferation and invasion. PMID: 22420896
    19. The data of study suggested that HMGN5 may play a critical role in the development of gliomas. PMID: 21373965
    20. these results suggest that NSBP1 promotes the viability of bladder cancer cells through increased cell proliferation PMID: 21695596
    21. HMGN5 has a highly disordered structure, binds dynamically to nucleosome core particles, modulates the binding of H1 to chromatin, reduces the compaction of the chromatin fiber, and affects transcription. PMID: 21518955
    22. A positive correlation was observed between NSBP1 expression and cell proliferation and apoptosis in DU145 cells. PMID: 20531280
    23. The structure of the HMGN5 gene and the known properties of the HMGN5 protein, are described. PMID: 20123071

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    HMGN family
  • 組織特異性:
    Ubiquitously expressed.
  • 數據庫鏈接:

    HGNC: 8013

    OMIM: 300385

    KEGG: hsa:79366

    STRING: 9606.ENSP00000350848

    UniGene: Hs.282204



主站蜘蛛池模板: 一本一道波多野结衣一区| 日日噜噜噜夜夜爽爽狠狠| 国产真实乱对白精彩| 国色精品卡一卡2卡3卡4卡在线| 国产av无码专区亚洲aⅴ| 无码人妻h动漫中文字幕| 2020精品国产自在现线看| 国产精品激情欧美可乐视频 | 久久九九精品国产av片国产| 日韩不卡1卡2卡三卡网站| 狠狠cao日日穞夜夜穞av| 亚洲乱亚洲乱妇| 国色天香社区视频手机免费 | 亚洲国产午夜精品理论片| 永久免费毛片在线播放| 国产精品久久人妻无码| 国产天美传媒性色av| 国模小婕私拍鲜嫩玉门| 亚洲v国产v天堂a无码二区| 特黄做受又粗又大又硬老头| 狠狠躁天天躁夜夜躁婷婷| 日本特黄特色特爽大片| 亚洲成国产人片在线观看| 日韩精品 中文字幕 视频在线 | 女的被弄到高潮娇喘喷水视频| 亚洲国产成人爱av在线播放| 国产制服丝袜欧美在线观看| 人妻丰满熟妇av无码区乱| 色综合久久久久无码专区| 国产xxx视频在线观看软件| 国产日韩一区二区三区在线观看| 久久久久久综合网天天| 亚洲aⅴ在线无码天堂777| 国内精品久久久久久久电影视| 欧美成人片一区二区三区| √最新版天堂资源在线| 国产女人天天春夜夜春| 久久无码精品一区二区三区| 国产精品99久久久久久www| 久久er99国产精品免费| 亚洲精品成人av在线|