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  4. HMGN3 Antibody, FITC conjugated

HMGN3 Antibody, FITC conjugated

  • 中文名稱：
    HMGN3兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA623009LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) HMGN3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    HMGN3
  • 別名：
    DKFZp686E20226 antibody; FLJ42187 antibody; High mobility group nucleosomal binding domain 3 antibody; High mobility group nucleosome-binding domain-containing protein 3 antibody; HMGN3 antibody; HMGN3_HUMAN antibody; OTTHUMP00000016772 antibody; OTTHUMP00000016773 antibody; PNAS 24 antibody; PNAS 25 antibody; PNAS24 antibody; PNAS25 antibody; Thyroid hormone receptor interacting protein 7 antibody; Thyroid receptor-interacting protein 7 antibody; TR-interacting protein 7 antibody; TRIP 7 antibody; TRIP-7 antibody; TRIP7 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human High mobility group nucleosome-binding domain-containing protein 3 protein (1-77AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function.
  • 基因功能參考文獻：
    1. The SNPs in the region of HMGN3 gene formed a tightly combined haplotype block in both Chinese and Caucasians. The results suggest that the genomic region containing HMGN3 gene may be associated with spine BS in Chinese. PMID: 21947420
    2. loss of HMGN3 impairs glucose-stimulated insulin secretion and leads to a diabetic phenotype. PMID: 19651901
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    HMGN family
  • 組織特異性：
    Expressed in kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate and uterus. Low expression in liver, spleen, placenta and ovaries.
  • 數據庫鏈接：

    HGNC: 12312

    OMIM: 604502

    KEGG: hsa:9324

    STRING: 9606.ENSP00000341267

    UniGene: Hs.77558



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