在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. HMGB2 Antibody

HMGB2 Antibody

  • 中文名稱：
    HMGB2兔多克隆抗體
  • 貨號：
    CSB-PA987394
  • 規格：
    ￥1100
  • 圖片：
    • Gel: 10%SDS-PAGE,Lysate: 40 μg,Lane 1-2: Hela cells, Raw264.7 cells,Primary antibody: CSB-PA987394(HMGB2 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 40 seconds
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    HMGB2
  • 別名：
    C80539 antibody; High mobility group (nonhistone chromosomal) protein 2 antibody; High mobility group box 2 antibody; High mobility group protein 2 antibody; High mobility group protein B2 antibody; HMG 2 antibody; HMG B2 antibody; HMG-2 antibody; HMG2 antibody; HMGB2 antibody; HMGB2_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human HMGB2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity. Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors. In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE. Has antimicrobial activity in gastrointestinal epithelial tissues. Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity. Involved in modulation of neurogenesis probably by regulation of neural stem proliferation. Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway.
  • 基因功能參考文獻：
    1. HMBG2 overexpression promotes ischemia/reperfusion-induced cell apoptosis through activating the JNK1/2-NF-kappaBp65 signaling in AC16 cardiomyocytes. PMID: 30119172
    2. Authors demonstrate that HMGB2 transcription is repressed by p21 during radiation-induced senescence through the ATM-p53-p21 DNA damage signaling cascade. The loss of p21 abolished the downregulation of HMGB2 caused by ionizing radiation, and the conditional induction of p21 was sufficient to repress the transcription of HMGB2. PMID: 29487276
    3. identified the oncogene HMGB2 as a downstream target of miR-130a by using luciferase and western blot assays. Knockdown of HMGB2 mimicked the effect of miR-130a in glioma cells. PMID: 28851665
    4. Serum HMGB2 levels were associated with in-stent restenosis in patients. PMID: 28183701
    5. results establish HMGB2 as a novel master regulator that orchestrates senescence-associated secretory phenotype. PMID: 27799366
    6. Data indicate the function of high mobility group box 2 (HMGB2) in glycolytic control in pancreatic cancer. PMID: 28069585
    7. data demonstrate a reciprocal relationship between Hmgb2 and Ctcf in controlling aspects of chromatin structure and gene expression. PMID: 27226577
    8. Lrp1-antisense directly binds to high-mobility group box 2 (Hmgb2) and inhibits the activity of Hmgb2 to enhance Srebp1a-dependent transcription of Lrp1. PMID: 25937287
    9. Data show that odulation of RNA helicase DDX18 directly affects growth of tamoxifen-resistant cells, suggesting that it may be a critical downstream effector of the estrogen receptors (ERs) and high mobility group box 2 (HMGB2) complex. PMID: 25284587
    10. siRNA-mediated silencing of HMGB2 increased the sensitivity of the head and neck squamous cell carcinoma cell lines to cisplatin and 5-fluorouracil. PMID: 25327479
    11. The present data suggest that HMGB2 expression is a significant prognostic factor for glioblastoma and might play an important role in cell invasion. PMID: 23828241
    12. HMGB2 is necessary to protect colorectal cancer cells from DNA damage and efficient DNA repair and p53-mediated downregulation is a critical mechanism of modulating HMGB2 expression. PMID: 23255232
    13. Transient local HMGB2-DNA contacts dominate the DNA-bending mechanism used by HMGB proteins to increase DNA flexibility. PMID: 23143110
    14. The age-related loss of HMGB2 in articular cartilage may represent a mechanism responsible for the decline in adult cartilage stem cell populations. PMID: 21890638
    15. The results can partly be explained by altered cell proliferations by HMGB2 associated with the antiapoptotic pathway. PMID: 20851854
    16. Our findings collectively suggest that HMGB2 could stabilize p53 by interfering with E6/E6AP-mediated p53 degradation in HPV-positive HeLa cells. PMID: 20036050
    17. HMGB2 potentiates GATA-1-dependent transcription of GFI1B by Oct-1 and thereby controls erythroid differentiation. PMID: 19965638
    18. HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A. PMID: 11909973
    19. binds specifically to the first AT-rich region flanking the hypersensitive site 2 core sequence of the human beta-globin gene locus control region PMID: 12555809
    20. biophysical analysis of HMG domain from human HMGB2 binding to DNA PMID: 15833996
    21. HMG2 was determined in humans. PMID: 17406091
    22. single and double box proteins increase DNA flexibility and stability, albeit both effects are achieved at much lower protein concentrations for the double box. PMID: 17964600
    23. In human and murine cartilage, there is an aging-related loss of HMGB2 expression, ultimately leading to its complete absence. PMID: 19139395
    24. An isolated HMG box A domain from human HMGB2 does not enhance DNA flexibility. Substitution of a small number of cationic residues from the N-terminal leader of a functional yeast box B protein, Nhp6Ap, confers the ability to enhance DNA flexibility. PMID: 19236006

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Chromosome. Cytoplasm. Secreted.
  • 蛋白家族：
    HMGB family
  • 組織特異性：
    Expressed in gastric and intestinal tissues (at protein level).
  • 數據庫鏈接：

    HGNC: 5000

    OMIM: 163906

    KEGG: hsa:3148

    STRING: 9606.ENSP00000296503

    UniGene: Hs.434953



主站蜘蛛池模板： 欧美成人天天综合在线| 天堂aⅴ无码一区二区三区| 亚洲免费综合色在线视频| 少妇高潮太爽了在线观看欧美| 国产精品久久久久9999高清| 无码人妻一区二区三区在线视频 | 日产精品一区二区| 国产精品igao视频网| 久久综合狠狠综合久久综| 狠狠色狠狠色综合日日五| 天堂网在线.www天堂在线资源| 久久精品国产福利一区二区| 2021少妇久久久久久久久久| 国模杨依粉嫩蝴蝶150p| 亚洲国产婷婷六月丁香| 女人被躁到高潮免费视频 | 免费观看四虎精品国产地址| 亚洲男人的天堂在线aⅴ视频| 色狠狠成人综合网| 国产精品亚洲一区二区无码| 久久亚洲日韩av一区二区三区| av 日韩 人妻 黑人 综合 无码| 欧美黑人添添高潮a片www| 亚洲欧美日韩综合久久| 人人莫人人擦人人看| 欧美性猛交ⅹxxx乱大交妖精| 无码日本精品xxxxxxxxx| 欧美色偷偷亚洲天堂bt| 欧美人与牲动交xxxx| 日韩精品无码一区二区三区| 在线毛片片免费观看| 吃奶呻吟打开双腿做受视频| 精品久久国产字幕高潮| 国产玉足脚交极品在线播放 | 亚洲国产a∨无码中文777 | 永久免费观看美女裸体的网站| 国产成人av一区二区三区无码 | 日本三级手机在线播放线观看 | 色一情一区二区三区四区| 亚洲高清国产av拍精品青青草原 | 精品无码国产自产拍在线观看|