在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HM13 Antibody, HRP conjugated

  • 中文名稱:
    HM13兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA851544LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) HM13 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    HM13
  • 別名:
    dJ324O17.1 antibody; H13 antibody; hIMP1 antibody; Histocompatibility (minor) 13 antibody; HM13 antibody; HM13_HUMAN antibody; IMP-1 antibody; IMP1 antibody; IMPAS antibody; IMPAS-1 antibody; Intramembrane protease 1 antibody; Intramembrane protease antibody; Minor histocompatibility antigen 13 antibody; Minor histocompatibility antigen H13 antibody; MSTP086 antibody; OTTHUMP00000030527 antibody; OTTHUMP00000030528 antibody; OTTHUMP00000030530 antibody; OTTHUMP00000214528 antibody; Presenilin-like protein 3 antibody; PSENL3 antibody; PSL3 antibody; Signal peptide peptidase antibody; Signal peptide peptidase beta antibody; SPP antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Minor histocompatibility antigen H13 protein (336-377AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner. May play a role in graft rejection.
  • 基因功能參考文獻:
    1. Preproinsulin signal peptide epitopes are processed by SPP and loaded for HLA-guided immune recognition via pathways that are enhanced during type 1 diabetes pathogenesis. PMID: 29343547
    2. Though far from complete, our knowledge on pathophysiological functions of SPP/SPPL proteases, in particular based on studies in mice, has been significantly increased over the last years. Based on this, inhibition of distinct SPP/SPPL proteases has been proposed as a novel therapeutic concept e.g. for the treatment of autoimmunity and viral or protozoal infections, as we will discuss in this review. PMID: 28624439
    3. The domains involved in HO-1 translocation have been identified, and it was shown that SPP-mediated HO-1 cleavage is isoform-specific (HO-1 vs HO-2) and independent of heme oxygenase activity. PMID: 29155886
    4. This study identifies that SPP affects EGFRvIII secretion profiles and thus promotes tumor progression, providing further understanding of the formation of secreted vesicles and driving role of EGFRvIII in Glioblastoma. PMID: 28198167
    5. structure of human SPP [SPP] PMID: 21636854
    6. identified human signal peptide peptidase as a polytopic membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases [SPP] PMID: 12077416
    7. identification and molecular cloning; expression analysis of the hIMP1 gene (located on chromosome 20) was performed in human cell tissues and transfected cell cultures [IMP1] PMID: 12139484
    8. widespread expression of SPP in many tissues PMID: 12972007
    9. signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor PMID: 14704149
    10. IMP1 is a bi-aspartic polytopic protease capable of cleaving transmembrane proteins such as presenilin 2. PMID: 14741365
    11. The peptide structure corresponding to the C-terminal residues from H13 ribosomal protein was determined using magnetic resonance spectroscopy. PMID: 14988012
    12. data implicate SPP in the US2 pathway and indicate the possibility of a previously unknown function for this intramembrane-cleaving aspartic protease in dislocation from the endoplasmic reticulum PMID: 16738546
    13. Upon isolation of membranes and solubilization with detergent, the biochemical characteristics of SPP are remarkably similar to gamma-secretase. PMID: 16834339
    14. Compares a variant from the mouse ortholog to the human gene. PMID: 16730383

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein; Lumenal side.; [Isoform 4]: Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Peptidase A22B family
  • 組織特異性:
    Widely expressed with highest levels in kidney, liver, placenta, lung, leukocytes and small intestine and reduced expression in heart and skeletal muscle. Expressed abundantly in the CNS with highest levels in thalamus and medulla.
  • 數據庫鏈接:

    HGNC: 16435

    OMIM: 607106

    KEGG: hsa:81502

    UniGene: Hs.373741



主站蜘蛛池模板: 国产精品调教视频一区| 精品国产一区二区三区免费| 亚洲精品乱码久久久久久中文字幕| 在线 | 一区二区三区四区| 欧美性猛交99久久久久99按摩| 天天噜日日噜狠狠噜免费| 水蜜桃av无码一区二区| 色婷婷综合久久久久中文一区二区| 国产99在线 | 免费| 日韩午夜理论免费tv影院| 国内自拍久久久久影院| 国产精品无码一本二本三本色| 国产精品一久久香蕉国产线看观看| 国产色无码精品视频国产| 日本乱偷互换人妻中文字幕| 久久综合给合久久国产免费| 18禁止观看强奷免费国产大片| 日韩中文亚洲欧美视频二| 中字幕视频在线永久在线观看免费| 国产极品美女高潮无套在线观看| 24小时日本在线www免费的| 国精品无码av人妻受辱系| yy111111少妇影院无码| 免费观看成人欧美www色| 人妻无码一区二区三区四区| 日本少妇高潮喷水视频| 奇米四色7777中文字幕| 性色av一区二区三区咪爱四虎| 无限看片在线版免费视频大全| 爱性久久久久久久久| 国产成人午夜福利在线播放| 男女做爰猛烈啪啪吃奶动| 日韩好精品视频你懂的| 欧美奶涨边摸边做爰视频| 欧美交换配乱吟粗大25p| 国产av老师丝袜美腿丝袜| 国产精品天干在线观看| 久久精品国产99久久6| 免费中文字幕日韩欧美| 特黄做受又粗又长又大又硬| 国产一本一道久久香蕉|