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HLCS Antibody

  • 中文名稱：
    HLCS兔多克隆抗體
  • 貨號(hào)：
    CSB-PA010518LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA010518LA01HU diluted at 1:200 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA010518LA01HU diluted at 1:200 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) HLCS Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    HLCS
  • 別名：
    Biotin [acetyl CoA carboxylase] ligase antibody; Biotin [methylcrotonoyl CoA carboxylase] ligase antibody; Biotin [methylmalonyl CoA carboxytransferase] ligase antibody; Biotin [propionyl CoA carboxylase [ATP hydrolyzing]] ligase antibody; Biotin apo protein ligase antibody; Biotin apo-protein ligase antibody; Biotin protein ligase antibody; Biotin--[acetyl-CoA-carboxylase] ligase antibody; BPL1_HUMAN antibody; HCS antibody; HLCS antibody; Holocarboxylase synthetase antibody; Holocarboxylase synthetase, EC 6.3.4 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Biotin--protein ligase protein (603-714AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，HLCS Antibody (CSB-PA010518LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于HLCS Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA010518LB01HU HLCS Antibody, HRP conjugated ELISA
    FITC CSB-PA010518LC01HU HLCS Antibody, FITC conjugated
    Biotin CSB-PA010518LD01HU HLCS Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase.
  • 基因功能參考文獻(xiàn)：
    1. The function of HCS and biotin in metabolism and human disease, a putative role for the enzyme in histone biotinylation, and its participation as a nuclear factor in chromatin dynamics is discussed. PMID: 28564555
    2. The transcriptional function of HCS was shown by in vitro pull down and in vivo co-immunoprecipitation assays to depend on its interaction with the histone deacetylases HDAC1, HDAC2 and HDAC7 PMID: 24239178
    3. Data suggest that direct interactions of HLCS (holocarboxylase synthetase) with NCOR1 (nuclear receptor corepressor 1) and HDAC1 (histone deacetylase 1) contribute toward transcriptional repression of repeats, presumably increasing genome stability. PMID: 24840043
    4. study characterizes three functional promoters in the human HLCS gene PMID: 24075901
    5. HLCS interacts physically with the DNA methyltransferase DNMT1 and the methyl CpG binding protein MeCP2 to facilitate the binding of HLCS to chromatin. PMID: 23624957
    6. This study showed that modification of HSP72 and demonstrated that binding of biotin to extracellular HSP72 prepares cells for a strong immune response. PMID: 24133061
    7. individuals with HLCS SNPs may benefit from supplemental biotin, yet to different extents depending on the genotype PMID: 22027809
    8. HLCS methionine-58 is a functional translation start site in human cells. PMID: 21802411
    9. Holocarboxylase synthetase interacts directly with histone H3, causing biotinylation of lysine K9 and K18. PMID: 20688500
    10. Mutation analysis by polymerase chain reaction-sequencing of the entire coding region of the HLCS gene revealed the c.1522C>T (p.R508W) mutation in six of the eight mutant alleles. suggests it as the most common mutation in the Thai population PMID: 20095979
    11. The results of this study suggest that miR-539 is among the factors sensing biotin and regulating holocarboxylase synthetase expression. PMID: 20592104
    12. Data suggest that the N-terminal domain of hHCS recognizes the charged region of biotin acceptor protein, distinctly from the recognition by the catalytic domain. PMID: 20085763
    13. the localisation of HCS and its isoforms PMID: 20153287
    14. The mutations R508W and V363D of holocarboxylase synthetase might be hot-spots in Chinese children with holocarboxylase synthetas deficiency. PMID: 19695181
    15. The study shows that not all the proteins and polypeptides that interact with holocarboxylase synthetase are targets for biotinylation, but that carboxylase- and histone-like structures are preferred HCS targets. PMID: 20026029
    16. These results provide insights into substrate recognition by hHCS, which can be distinguished from BirA in this respect. PMID: 19914215
    17. 12 patients with multiple carboxylase deficiency, six mutations were found in the BT gene and 4 in the HLCS gene, including 5 novel mutations. PMID: 19806568
    18. 6 HLCS mutations were identified, including 2 new (N511K and G582R) and 4 known missense mutations (L216R, R508W, V550M, and G581S). 5 are in the biotin-binding domain. Tthe L216R change is in the N-terminal region outside the biotin-binding domain. PMID: 12124727
    19. Detection of mutations by tandem mass spectrometry in Carnitine transporter deficiency. PMID: 17417720
    20. findings from this study are consistent with the theory that HCS senses biotin, and that biotin regulates its own cellular uptake by participating in HCS-dependent chromatin remodeling events at the SMVT promoter 1 locus in Jurkat cells. PMID: 17904341
    21. Study investigated cell lines from 2 HLCS-deficient patients p.L216R allele; enzyme activity was decreased for p.L216R and could not be increased by additional biotin; furthermore, the turn-over rate for the mutant protein was double that of wildtype. PMID: 18429047
    22. Biotinylation of histones by BirA ligase is consistent with the proposed role of human HCS in chromatin. PMID: 18452652
    23. The aim of this study was to investigate the effects of holocarboxylase synthetase (HCS) gene to irradiation in a time- and dose-dependent manner. PMID: 19048367
    24. The hypothesis that N- and C-termini play roles in substrate recognition by HCS, was tested. PMID: 19157941
    25. Amino termini of HCS influence biotin acceptor substrate recognition PMID: 19740736

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  • 相關(guān)疾病：
    Holocarboxylase synthetase deficiency (HLCS deficiency)
  • 亞細(xì)胞定位：
    Cytoplasm. Mitochondrion.
  • 蛋白家族：
    Biotin--protein ligase family
  • 組織特異性：
    Widely expressed. Mostly expressed in muscle, placenta and to a lower extent in the brain, kidney, pancreas, liver and lung.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 4976

    OMIM: 253270

    KEGG: hsa:3141

    STRING: 9606.ENSP00000338387

    UniGene: Hs.371350



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