在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. HLA-DRB4 Antibody, HRP conjugated

HLA-DRB4 Antibody, HRP conjugated

  • 中文名稱：
    HLA-DRB4兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA03909B0Rb
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) HLA-DRB4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    DR 4 antibody; DR beta 4 chain antibody; DR4 antibody; DRB1 transplantation antigen antibody; DRB4 antibody; DRB4_HUMAN antibody; HLA class II histocompatibility antigen antibody; HLA class II histocompatibility antigen DR beta 4 chain antibody; HLA-DRB4 antibody; Human leucocyte antigen DRB4 antibody; Leukocyte antigen antibody; Major histocompatibility complex class II DR beta 4 antibody; MHC class II antigen DRB4 antibody; MHC class II antigen HLA DR beta antibody; MHC class2 antigen antibody; MHC HLA DR-beta chain antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human HLA class II histocompatibility antigen, DR beta 4 chain protein (30-227AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
  • 基因功能參考文獻：
    1. We developed an human cardiac alpha-myosin -induced myocarditis model in human HLA-DR4 transgenic mice that lack all mouse MHCII genes. PMID: 28431892
    2. Strong association of nontumor anti-LGI1 encephalitis with HLA-DRB4. PMID: 28026046
    3. HLA-DR4 is a susceptibility factor for the development of AIH. Impaired suppressive function of Tregs and reduced PD-1 expression may result in spontaneous activation of key immune cell subsets, such as antigen-presenting cells and CD8(+) T effectors, facilitating the induction of AIH and persistent liver damage. PMID: 27414259
    4. HLA-DRB4 affects type 1 diabetes risk and islet autoantibodies. PMID: 26740600
    5. The study identifies a region of focus for B and T cell responses to IA-2 in HLA-DR4 diabetic patients that may explain HLA associations of IA-2 autoantibodies. PMID: 25225671
    6. HLA-DR4 codes for susceptibility to RF+ polyarticular JIA with a six-fold risk. PMID: 24618287
    7. The HLA- DR4 gene was clearly associated with susceptibility to rheumatoid arthritis. PMID: 23537298
    8. Data indicate that invariant NKT (iNKT) cell-mediated cytokine secretion in staphylococcal enterotoxin B (SEB)-challenged HLA-DR4-transgenic mice was CD1d-independent. PMID: 22041925
    9. Elevated frequencies of HLA-DR4 and HLA-DR5 alleles were found in patients with idiopathic dilated cardiomyopathy compared with controls. PMID: 21556773
    10. DRB4*01:08 is a novel HLA-DRB4 allele PMID: 21410658
    11. HLA-DR14/DR7/DQ5 alleles significantly increase the risk for toxic shock syndrome, regardless of individual variations in T cell receptor variable region repertoires. PMID: 21282506
    12. IA2 positivity was associated with HLA-DR4/X and HLA-DR3/4 positivity, and hypothyroidism was linked to HLA-DR4/4. More females carried the HLA-DR4/4 genotype or were thyroid antibody positive. PMID: 20371654
    13. Our results revealed HLA-DRB1*04 as predisposing factor in papillary thyroid carcinoma in Iranian population. PMID: 20164547
    14. Complete coding sequence of the HLA alleles DRB4*0103101 and DRB4*01033 PMID: 11972878
    15. DRB4 was increased in males with childhood ALL compared to age- and sex-matched controls) and female patients. HLA-DRB4 is over-represented in high-risk patients. The HLA system may be a component of genetic leukemia susceptibility in male children only. PMID: 12008082
    16. Comparison of HLA-DR4-associated peptides in neuroendocrine cells with those identified in lymphoblastoid B cells (LCLs) suggests that intracellular pathways allowing HLA-DR endogenous peptide processing are more efficient in endocrine cells than in LCLs. PMID: 12391221
    17. A novel allele of HLA-DRB4 was found. PMID: 12859598
    18. differential expression of genes encoded within the RA-associated HLA-DR4 superhaplotype and within the neutral DR7 and DR9 superhaplotypes. PMID: 14558083
    19. In patients with autoimmune thyroiditis the HLA-DR11 frequency was higher than control values, while in patients with autoimmune polyglandular syndrome type II, the HLA-DR3 frequency was found to be higher. PMID: 15046556
    20. Interaction between the HLA-DRB4 and CTLA-4 genes determines the thyroid function of TPO-positive goitrous Japanese Hashimoto's thyroiditis patients. PMID: 15055474
    21. No definite association was found between HLA-DR alleles and the risk of psoriasis or psoriatic arthritis. PMID: 15513680
    22. HIP is an islet protein naturally processed and presented by HLA-DR4 molecules PMID: 15721314
    23. Genetic variation associated with type 1 diabetes in a Czech Republic population with childhood onset. PMID: 16629714
    24. a diabetic intrauterine environment interacts with gene(s) marked by the type 1 diabetes susceptibility HLA DR4 alleles to increase fetal growth PMID: 17310371
    25. The shared epitope assessed on all HLA-DRB1 serotypic backgrounds except DR1 was associated with RA susceptibility. The presence of the shared epitope on DR4 is associated with greater RA susceptibility and certain disease-activity measures. PMID: 17491100
    26. findings indicate that HLA-DRB4 is a genetic risk factor for the development of Churg-Strauss syndrome and increases the likelihood of development of vasculitic manifestations of the disease. PMID: 17763415
    27. DRB1*04 may be a protective factor in paucibacillary leprosy. PMID: 18053473
    28. A model of mixed connective tissue disease has been developed in mice that express the transgene HLA-DRA*0101/DRB1*0401 in a fusion protein with U1-70-kDa ribonucleoprotein autoantigen. PMID: 18523312
    29. Thirty-eight percent of the B burgdorferi-infected DR4+/+CD28(-/-)MHCII(-/-) mice, but none of the B burgdorferi-infected CD28(-/-)MHCII(-/-) mice, remained arthritic post-antibiotic treatment PMID: 19035513
    30. associated with antiphospholipid syndrome PMID: 19052923
    31. Significant transmission disequilibrium for HLA-DR4 was seen (odds ratio, 4.67; 95% confidence interval, 1.34-16.24; P = .008) for transmissions from maternal grandparents to mothers of probands. PMID: 19487610

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
  • 蛋白家族：
    MHC class II family
  • 數據庫鏈接：

    HGNC: 4952

    KEGG: hsa:3126

    UniGene: Hs.534322



主站蜘蛛池模板： 日本三级理论久久人妻电影| 日韩去日本高清在线| 欧美熟妇性开放| 国产a精彩视频精品视频下载| 日本高清色www网站色噜噜噜| 国产美女久久精品香蕉| 伊人精品成人久久综合97| 巨大巨粗巨长 黑人长吊| 色婷婷亚洲一区二区三区| 成品人视频ww入口| 无人区码一码二码w358cc| 亚洲欧美日韩在线资源观看| 亚洲精品午夜一区二区电影院| 久久99精品国产99久久6不卡| 久久久久国产a免费观看rela| 中文在线а√天堂| 亚洲精品天天影视综合网| 非洲黑人性xxxx精品| 亚洲欧美中文字幕日韩一区二区| 在线观看片a免费不卡观看| 久久精品国产色蜜蜜麻豆| 国产suv精品一区二区6 | 久久精品国产99久久6动漫| 女人夜夜春高潮爽a∨片传媒| 免费无码专区在线视频| 76少妇精品导航| 天天弄天天模| 99热99这里只有高清国产| 久久久无码精品国产一区| 自拍偷在线精品自拍偷免费| 日本少妇高潮喷水xxxxxxx| 久久久精品国产sm调教网站| 人妻少妇精品专区性色av| 亚洲最大的熟女水蜜桃av网站| 国产精品自在拍在线拍| 97人妻精品一区二区三区| 色综合天天综合天天更新| 亚洲中文无码线在线观看| 成在线人视频免费视频| 亚洲鲁丝片一区二区三区| 欧美乱大交aaaa片if|