在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. HLA-DMB Antibody

HLA-DMB Antibody

  • 中文名稱：
    HLA-DMB兔多克隆抗體
  • 貨號：
    CSB-PA561724
  • 規格：
    ￥1090
  • 圖片：
    • Immunohistochemical analysis of paraffin-embedded Human-tonsil, antibody was diluted at 1:100
    • Immunohistochemical analysis of paraffin-embedded Human-tonsil, antibody was diluted at 1:100
    • Immunohistochemical analysis of paraffin-embedded Human-colon, antibody was diluted at 1:100
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    HLA-DMB antibody; DMB antibody; RING7HLA class II histocompatibility antigen antibody; DM beta chain antibody; MHC class II antigen DMB antibody; Really interesting new gene 7 protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide from Human protein at AA range: 40-100
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 純化方式：
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    IHC,ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC IHC-p:1:50-300
    ELISA 1:10000-20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
  • 基因功能參考文獻：
    1. This study provides novel insights into how HLA-DM efficiently catalyzes peptide loading during antigen presentation. PMID: 26062997
    2. Data suggest that antigen processing by MHC class II HLA-DMB antigen is a target pathway in the pathogenesis of HIV-related Kaposi's sarcoma. PMID: 25008864
    3. Overexpression of HLA-DM at the plasma membrane of dendritic cells improves quantitatively, but also qualitatively, the presentation of CD4-expressing T cell epitopes in cellular vaccine therapies for cancer. PMID: 21622867
    4. HLA-DM mediates a noncooperative release of prebound influenza virus hemagglutinin peptides from wild-type HLA-DR1 by destabilizing the beta81 hydrogen (H-)bond, since a similar phenomenon is observed when this H-bond is absent. PMID: 20038641
    5. HLA-DMB may play an important role in pathogenesis of type 1 diabetes, and clinical status heterogeneity of type 1 diabetes may be related to genetic mechanism. PMID: 14754527
    6. findings suggest HLA-DM expression in antigen presenting cells controls class II-mediated type II collagen(261-273) peptide/epitope presentation & regulates CD4+ T cell responses to this self epitope, potentially influencing CII-dependent autoimmunity PMID: 18506881
    7. Tumor cell expression of HLA-DMB is associated with increased numbers of tumor-infiltrating CD8 T lymphocytes and both are associated with improved survival in advanced-stage serous ovarian cancer. PMID: 19047092
    8. No individual component of conserved HLA-DM hydrogen bond network demonstrates an essential role in the DM catalytic mechanism. Catalytic potency of HLA-DM with each beta-chain mutant was equal to or greater than that observed with wild-type HLA-DR1. PMID: 19767569

    顯示更多

    收起更多

  • 亞細胞定位：
    Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Localizes to late endocytic compartment. Associates with lysosome membranes.
  • 蛋白家族：
    MHC class II family
  • 數據庫鏈接：

    HGNC: 4935

    OMIM: 142856

    KEGG: hsa:3109

    STRING: 9606.ENSP00000398890

    UniGene: Hs.351279



主站蜘蛛池模板： 青草精品国产福利在线视频| 国产色无码精品视频国产| 九九综合九色综合网站| 亚洲欧美综合国产精品二区| 亚洲欧美中文日韩v在线97| 肉色欧美久久久久久久免费看| 色av综合av综合无码网站| 重口sm一区二区三区视频| 国产亚洲日本精品无码| 五十路熟女一区二区三区 | 饥渴少妇av无码影片| 日本亚欧热亚洲乱色视频| 色欲综合一区二区三区| 无尺码精品产品日韩| 国内外精品激情刺激在线| 99久久久国产精品消防器材| 18禁美女裸体无遮挡网站| 中文字幕人妻高清乱码| 综合自拍亚洲综合图区欧美| 亚洲成成熟女人专区| 欧美丰满熟妇bbbbbb百度| 亚洲成色在线综合网站| 狠狠色噜噜狠狠狠狠蜜桃| 又大又紧又粉嫩18p少妇| 国自产拍偷拍精品啪啪一区二区| 欧美va免费高清在线观看| 亚洲日本乱码一区二区产线一∨| 国产农村老太xxxxhdxx| 国产精品-区区久久久狼| 无码任你躁久久久久久老妇蜜桃 | 国产无遮挡又黄又爽又色| 久久亚洲精品成人av二次元| 久久精品人人做人人综合| 色爽黄1000部免费软件下载| 国产成人综合亚洲色就色| 亚洲无线码一区二区三区| 把腿张开老子臊烂你多p视频| 中文字幕无码乱码人妻系列蜜桃 | 日韩欧美一中文字暮专区| 日韩av高潮喷水在线观看| 亚洲人成网站色7799|