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  4. HLA-DMB Antibody

HLA-DMB Antibody

  • 中文名稱：
    HLA-DMB兔多克隆抗體
  • 貨號：
    CSB-PA561724
  • 規格：
    ￥1090
  • 圖片：
    • Immunohistochemical analysis of paraffin-embedded Human-tonsil, antibody was diluted at 1:100
    • Immunohistochemical analysis of paraffin-embedded Human-tonsil, antibody was diluted at 1:100
    • Immunohistochemical analysis of paraffin-embedded Human-colon, antibody was diluted at 1:100
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    HLA-DMB antibody; DMB antibody; RING7HLA class II histocompatibility antigen antibody; DM beta chain antibody; MHC class II antigen DMB antibody; Really interesting new gene 7 protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide from Human protein at AA range: 40-100
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 純化方式：
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    IHC,ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC IHC-p:1:50-300
    ELISA 1:10000-20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
  • 基因功能參考文獻：
    1. This study provides novel insights into how HLA-DM efficiently catalyzes peptide loading during antigen presentation. PMID: 26062997
    2. Data suggest that antigen processing by MHC class II HLA-DMB antigen is a target pathway in the pathogenesis of HIV-related Kaposi's sarcoma. PMID: 25008864
    3. Overexpression of HLA-DM at the plasma membrane of dendritic cells improves quantitatively, but also qualitatively, the presentation of CD4-expressing T cell epitopes in cellular vaccine therapies for cancer. PMID: 21622867
    4. HLA-DM mediates a noncooperative release of prebound influenza virus hemagglutinin peptides from wild-type HLA-DR1 by destabilizing the beta81 hydrogen (H-)bond, since a similar phenomenon is observed when this H-bond is absent. PMID: 20038641
    5. HLA-DMB may play an important role in pathogenesis of type 1 diabetes, and clinical status heterogeneity of type 1 diabetes may be related to genetic mechanism. PMID: 14754527
    6. findings suggest HLA-DM expression in antigen presenting cells controls class II-mediated type II collagen(261-273) peptide/epitope presentation & regulates CD4+ T cell responses to this self epitope, potentially influencing CII-dependent autoimmunity PMID: 18506881
    7. Tumor cell expression of HLA-DMB is associated with increased numbers of tumor-infiltrating CD8 T lymphocytes and both are associated with improved survival in advanced-stage serous ovarian cancer. PMID: 19047092
    8. No individual component of conserved HLA-DM hydrogen bond network demonstrates an essential role in the DM catalytic mechanism. Catalytic potency of HLA-DM with each beta-chain mutant was equal to or greater than that observed with wild-type HLA-DR1. PMID: 19767569

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  • 亞細胞定位：
    Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Localizes to late endocytic compartment. Associates with lysosome membranes.
  • 蛋白家族：
    MHC class II family
  • 數據庫鏈接：

    HGNC: 4935

    OMIM: 142856

    KEGG: hsa:3109

    STRING: 9606.ENSP00000398890

    UniGene: Hs.351279



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