在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. HLA-DMB Antibody

HLA-DMB Antibody

  • 中文名稱：
    HLA-DMB兔多克隆抗體
  • 貨號：
    CSB-PA561724
  • 規格：
    ￥1090
  • 圖片：
    • Immunohistochemical analysis of paraffin-embedded Human-tonsil, antibody was diluted at 1:100
    • Immunohistochemical analysis of paraffin-embedded Human-tonsil, antibody was diluted at 1:100
    • Immunohistochemical analysis of paraffin-embedded Human-colon, antibody was diluted at 1:100
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    HLA-DMB antibody; DMB antibody; RING7HLA class II histocompatibility antigen antibody; DM beta chain antibody; MHC class II antigen DMB antibody; Really interesting new gene 7 protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide from Human protein at AA range: 40-100
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 純化方式：
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    IHC,ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC IHC-p:1:50-300
    ELISA 1:10000-20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
  • 基因功能參考文獻：
    1. This study provides novel insights into how HLA-DM efficiently catalyzes peptide loading during antigen presentation. PMID: 26062997
    2. Data suggest that antigen processing by MHC class II HLA-DMB antigen is a target pathway in the pathogenesis of HIV-related Kaposi's sarcoma. PMID: 25008864
    3. Overexpression of HLA-DM at the plasma membrane of dendritic cells improves quantitatively, but also qualitatively, the presentation of CD4-expressing T cell epitopes in cellular vaccine therapies for cancer. PMID: 21622867
    4. HLA-DM mediates a noncooperative release of prebound influenza virus hemagglutinin peptides from wild-type HLA-DR1 by destabilizing the beta81 hydrogen (H-)bond, since a similar phenomenon is observed when this H-bond is absent. PMID: 20038641
    5. HLA-DMB may play an important role in pathogenesis of type 1 diabetes, and clinical status heterogeneity of type 1 diabetes may be related to genetic mechanism. PMID: 14754527
    6. findings suggest HLA-DM expression in antigen presenting cells controls class II-mediated type II collagen(261-273) peptide/epitope presentation & regulates CD4+ T cell responses to this self epitope, potentially influencing CII-dependent autoimmunity PMID: 18506881
    7. Tumor cell expression of HLA-DMB is associated with increased numbers of tumor-infiltrating CD8 T lymphocytes and both are associated with improved survival in advanced-stage serous ovarian cancer. PMID: 19047092
    8. No individual component of conserved HLA-DM hydrogen bond network demonstrates an essential role in the DM catalytic mechanism. Catalytic potency of HLA-DM with each beta-chain mutant was equal to or greater than that observed with wild-type HLA-DR1. PMID: 19767569

    顯示更多

    收起更多

  • 亞細胞定位：
    Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Localizes to late endocytic compartment. Associates with lysosome membranes.
  • 蛋白家族：
    MHC class II family
  • 數據庫鏈接：

    HGNC: 4935

    OMIM: 142856

    KEGG: hsa:3109

    STRING: 9606.ENSP00000398890

    UniGene: Hs.351279



主站蜘蛛池模板： 精品玖玖玖视频在线观看| 欧美顶级少妇作爱| 999zyz玖玖资源站永久| 亚洲综合精品伊人久久| 国产成人久久a免费观看| av无码av无码专区| 啪一啪射一射插一插| 日韩a∨精品日韩在线观看| 亚洲精品92内射| 成年免费视频黄网站在线观看| av无码天堂一区二区三区| 97精品尹人久久大香线蕉| 国产一区二区三区无码免费| 中文字幕网伦射乱中文| 久久精品国产亚洲一区二区| 末发育娇小性色xxxxx| av无码不卡一区二区三区| 996热re视频精品视频这里| 国产精品卡一卡二卡三| 满春阁精品a∨在线观看| 午夜亚洲国产理论片二级港台二级| 国产精品无码无卡在线播放| 欧美性猛交99久久久久99按摩| 国产成人无码精品久久久免费 | 成人毛片无码免费播放网站| 最新无码人妻在线不卡| 丝袜美腿亚洲一区二区| 久久人人爽天天玩人人妻精品| 又大又粗又爽18禁免费看| 男女啪啪抽搐呻吟高潮动态图| 人妻无码精品久久亚瑟影视| 欧美老熟妇xb水多毛多| 国产日韩av无码免费一区二区| 久久精品国产国产精品四凭| 国产日产精品一区二区三区四区的特点 | 亚洲精品永久在线观看| 9re热国产这里只有精品| 人妻中出无码一区二区三区| 国产精品激情| 少女韩国电视剧在线观看完整 | 成人无码在线视频网站|