在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HJURP Antibody

  • 中文名稱:
    HJURP兔多克隆抗體
  • 貨號:
    CSB-PA010467GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    HJURP
  • 別名:
    HJURP antibody; FAKTS antibody; FLEG1 antibody; URLC9 antibody; Holliday junction recognition protein antibody; 14-3-3-associated AKT substrate antibody; Fetal liver-expressing gene 1 protein antibody; Up-regulated in lung cancer 9 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Human HJURP
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.
  • 基因功能參考文獻:
    1. Increased expression of HJURP was identified as an independent negative prognostic biomarker for patients with advanced serous ovarian cancer. PMID: 29743473
    2. during the CENP-A/H4 deposition process, the chaperone HJURP protects various substructures of the dimer, serving both as a folding and binding chaperone PMID: 27454815
    3. Functional p53 elicits a cell cycle arrest response, whereas, in p53-null transformed cells, the absence of arrest enables the loss of HJURP to induce severe aneuploidy and, ultimately, apoptotic cell death PMID: 28356341
    4. An increased occurrence of hepatocellular carcinoma was consistently associated with A/C or C/C genotypes of the non-synonymous SNP rs3771333 compared with the A/A genotype in both the Fusui and Haimen populations. PMID: 26863619
    5. Authors propose that this centromere expansion activity reflects the functional properties of HJURP, which uses this activity to contribute to the plastic establishment of a centromeric chromatin structure. PMID: 26063729
    6. 3 biomarkers in 44 patients with in situ breast cancers were evaluated: TG2 (transglutaminase 2), HJURP (Holliday junction recognition protein), and HIF-1alpha (hypoxia inducible factor-1 alpha). PMID: 25243117
    7. On the basis of our findings, we propose that HJURP serves a dual chaperone function in coordinating CenH3(CENP-A) and CENP-C recruitment. PMID: 25843710
    8. HJURP can discriminate favorable and unfavorable outcome within the luminal A subtype, outperforming the currently utilized proliferation marker Ki67, as an independent prognostic marker for luminal A patients. PMID: 25497280
    9. Phosphorylation state of HJURP controls its centromeric recruitment. HJURP binding to DNA promotes loading of CenH3CENP-A at centromeres. PMID: 25001279
    10. The study describes a novel function for human centromeric long non-coding RNAs in the recruitment of HJURP and CENP-A, implicating RNA-based chaperone targeting in histone variant assembly. PMID: 25117489
    11. The levels of the EDNRB, HJURP and p60/CAF-1 proteins were strongly associated with overall survival in high-grade gliomas patients (p<0.001, p<0.001 and p=0.002, respectively), whereas the one of PDLI4 was not (P=0.11). PMID: 24039914
    12. Mis18beta binds with and specifies the centromere localization of HJURP. PMID: 24519934
    13. HJURP has an important role in the maintenance of extremely proliferative cells of high-grade gliomas PMID: 23638004
    14. a mechanism whereby the CENP-A pre-nucleosomal complex achieves assembly of the octameric CENP-A nucleosome through the dimerization of the CENP-A chaperone HJURP. PMID: 23771058
    15. Downregulation of HJURP in young cells led to premature senescence. p53 knockdown, but not p16 knockdown, abolished senescence phenotypes caused by HJURP reduction. PMID: 23292286
    16. And-1 together with HJURP regulates the assembly of new CENP-A onto centromeres. PMID: 23184928
    17. stringent regulation of HJURP and SCM3 expression are critical for genome stability. PMID: 21980305
    18. An amino-terminal fragment of HJURP was able to assemble CENP-A nucleosomes in vitro, demonstrating that HJURP is a chromatin assembly factor. PMID: 21768289
    19. The crystal structure of an HJURP-CENP-A-histone H4 complex shows that HJURP binds a CENP-A-H4 heterodimer PMID: 21478274
    20. Data show that HJURP mRNA level is a prognostic factor for disease-free and overall survival in patients with breast cancer and is a predictive biomarker for sensitivity to radiotherapy. PMID: 20211017
    21. found that HJURP, a member of the complex, was required for cell cycle specific targeting of CENP-A to centromeres. PMID: 20080577
    22. HJURP is a possible cell-cycle-regulated CENP-A-specific histone chaperone required for centromeric chromatin assembly PMID: 19410544
    23. HJURP is a key factor for CENP-A deposition and maintenance at centromeres PMID: 19410545
    24. hFLEG1 is associated with the CENP-A centromeric nucleosome PMID: 16622419

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus, nucleolus. Chromosome, centromere. Note=Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage.
  • 組織特異性:
    According to PubMed:17256767, highly expressed in the thymus with lower levels in the placenta, small intestine, liver, skeletal muscle, and colon. According to PubMed:17823411, highly expressed in testis, and at a relatively lower level in thymus and bon
  • 數據庫鏈接:

    HGNC: 25444

    OMIM: 612667

    KEGG: hsa:55355

    STRING: 9606.ENSP00000414109

    UniGene: Hs.532968



主站蜘蛛池模板: 狠狠做深爱婷婷丁香综合| 办公丝袜av一区二区三区| 国产av区男人的天堂| 色欲来吧来吧天天综合网| 国产乱码一区二区三区爽爽爽| 久久一卡二卡三卡四卡| 玩弄少妇人妻中文字幕| 黄桃av无码免费一区二区三区| 性乌克兰xxxx极品| 日本三级理论久久人妻电影| 国产成人综合亚洲精品| 久热这里在线精品| 欧美无人区码suv| 国产麻豆md传媒视频| 日韩精品乱码av一区二区| 中文无码伦av中文字幕在线| 国产成人av在线影院无毒| a在线视频v视频| 亚洲熟女一区二区三区| 色综合久久88色综合天天| 亚洲mv国产mv在线mv综合试看| 国内精品视频一区二区八戒| 久久精品夜夜夜夜夜久久| 色国产精品一区在线观看| 粗大挺进尤物人妻中文字幕| 秋霞电影网午夜鲁丝片无码| 国色天香成人一区二区| 中国熟妇人妻xxxxx| 国产熟睡乱子伦视频| 97超碰精品成人国产| 欧美人与动zozo在线播放| 免费很黄无遮挡的视频| 亚洲国产精品成人久久蜜臀| 国产精品久久久久久无码| 狠狠色成人综合网| 天堂av色综合久久天堂| 国产精品国产精品国产专区不卡| 人妻丰满熟妞av无码区 | 国内精品久久毛片一区二区| 国产精品国产三级欧美二区| 中国丰满熟妇av|