在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HHIP Antibody

  • 中文名稱(chēng):
    HHIP兔多克隆抗體
  • 貨號(hào):
    CSB-PA850419ESR2HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: HHIPantibody IgG at 1.92μg/ml + Rat heart tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 79, 37 kDa
      Observed band size: 79 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA850419ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA850419ESR2HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng):
    Rabbit anti-Homo sapiens (Human) HHIP Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    FLJ20992 antibody; FLJ90230 antibody; Hedgehog interacting protein antibody; Hedgehog-interacting protein antibody; hedgehoginteracting protein antibody; HHIP antibody; HHIP_HUMAN antibody; Hip antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human, Rat
  • 免疫原:
    Recombinant Human Hedgehog-interacting protein (18-220AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類(lèi)型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family.
  • 基因功能參考文獻(xiàn):
    1. The rate of methylation of ZIC1, ZIC4, HHIP, and DACT2 in tumors was very high, while methylation of CXXC4 was low to moderate in OSCC and LSCC. PMID: 27553089
    2. Genetic variants in HHIP were related with FEV1/FVC in Chronic Obstructive Pulmonary Disease (COPD). Significant relationships between risk alleles and risk genotypes and FEV1/FVC in COPD were also identified. PMID: 28929109
    3. HHIP underexpression is associated with lung adenocarcinoma. PMID: 27015549
    4. HHIP plays a role in lung branching development, and reduced levels of HHIP ultimately result in lung hypoplasia. PMID: 27845578
    5. Single nucleotide polymorphism in HHIP gene is associated with chronic obstructive pulmonary disease. PMID: 28939338
    6. loss of AT2 R is associated with podocyte loss/dysfunction and is mediated, at least in part, via augmented ectopic hedgehog interacting protein expression in podocytes PMID: 28722118
    7. this study shows that HHIP confers a risk for airway obstruction in general that is not driven exclusively by cigarette smoking, which is the main risk factor for chronic obstructive pulmonary disease PMID: 27612410
    8. Results showed that smoking and HHIP variant rs7654947 were associated with chronic obstructive pulmonary disease (COPD)development and lung function decline. Moreover, we found that cigarette smoking and gene susceptibility have cooperative effects on COPD risk and lung function decline PMID: 28640141
    9. This work supports a feasible vicious cycle in which EMPs generated during endothelial injury, in turn, aggravate endothelial damage by carrying HHIP into target ECs, contributing to the continuously deteriorating endothelial damage in the development of aGVHD. EMPs harboring HHIP would represent a potential therapeutic target for aGVHD. PMID: 27009877
    10. HHIP expression and Gli1 expression were independent prognostic factors in glioblastoma. PMID: 26482617
    11. HHIP - candidate gene for Chronic Obstructive Pulmonary Disease identified by Genome-wide association studies. PMID: 26527870
    12. Shh-mediated degradation of Hhip allows cell autonomous and non-cell autonomous Shh signaling. PMID: 25215859
    13. HHIP might be a diagnostic or prognostic marker in glioma and help to the detection of these tumors in early stages of disease. PMID: 25416442
    14. HHIP is located within genes previously associated with chronic obstructive pulmonary disease susceptibility. PMID: 25006744
    15. Genetic variants in HHIP are associated with FEV1 in subjects with chronic obstructive pulmonary disease. PMID: 23731023
    16. The data demonstrated that loss of expression of HHIP and PTCH is associated with the methylation of gene promoters PMID: 23440386
    17. We show that GPC3, an hepatocellular carcinoma biomarker and Hh mediator, regulates human stellate cell viability by regulating Hh signaling. PMID: 24439425
    18. Data indicate that the Shh signaling transduction is facilitated by binding of Shh to its receptor protein, Ptch, and show the complex structure of Shh-Hhip. PMID: 23935859
    19. our study suggests that the HHIP gene may be involved in COPD susceptibility in Chinese Han population. PMID: 23994291
    20. HHIP, HDAC4, NCR3 and RARB polymorphisms may have a role in impaired lung function that begins in early life PMID: 23456936
    21. Identification of potential HHIP targets of gene expression regulation in chronic obstructive pulmonary disease. PMID: 23459001
    22. These data suggest that activated Hedgehog signalling contributes to the biology of human fetal rhabdomyomas. PMID: 23780909
    23. Results suggest involvement of the Hedgehog pathway in CPHD and that both SHH and HHIP are investigated as a second screening in CPHD, after mutations in the classical CPHD genes have been ruled out. PMID: 22897141
    24. no correlation between hedgehog activity and SHH, Gli1 and Patched1 mRNA levels was observed. other mechanisms aside from transcriptional regulation of these factors are responsible for hedgehog activity in tumor cells derived from GBM. PMID: 22406999
    25. GDC-0449 treatment is pharmacodynamically effective as evidenced by paracrine Hedgehog signaling inhibition and results in prostate cancer cell proliferation reduction. PMID: 22457212
    26. Low HHIP expression is associated with chronic obstructive pulmonary disease. PMID: 22140090
    27. Resveratrol inhibits proliferation and induces apoptosis through the hedgehog signaling pathway in pancreatic cancer cells.( PMID: 22301921
    28. Mutation of the hedgehog signaling patwhway play a key role in the development of basal cell carrcinomas. PMID: 20800318
    29. results suggest the possibility of epigenetic regulation of HHIP in medulloblastoma PMID: 20853133
    30. We found that HIP, PDGFRalpha, SMO and Su(Fu) gene highly expressed in the primary esophageal squamous cell carcinomas PMID: 21210262
    31. A subset of normal lung function genes, including HHIP, FAM13A, and PTCH1, together predict lung function abnormalities, a measure of severity in white and African American subjects with asthma. PMID: 21397937
    32. the GG genotype of the rs 1489759 HHIP single-nucleotide polymorphism (SNP) and the CC genotype of the rs 2202507 GYPA SNP confers a ''protective'' effect on COPD (OR 0.59, p50.006 for HHIP and OR50.65, p50.006 for GYPA) and lung cancer. PMID: 21119205
    33. The HHIP locus was associated with the systemic components of COPD and with the frequency of COPD exacerbations. PMID: 20656943
    34. Genetic variation near the Hip gene was significantly associated with risk of COPD, depending on the number of pack-years of smoking. PMID: 19996190
    35. These results suggest that reduced expression of HIP, a naturally occurring Hh pathway antagonist, in tumor neo-vasculature may contribute to increased Hh signaling within the tumor and possibly promote angiogenesis. PMID: 15294024
    36. The different pattern of expression and abnormal localization in the diseased pancreas suggest that the enhanced activation of hedgehog signaling in in pancreatic cancer and pancreatic duct carcinoma. PMID: 15754313
    37. Aberrant methylation of the Human Hedgehog interacting protein is associated with pancreatic neoplasms PMID: 15970691
    38. The down-regulation of HHIP transcription is due to DNA hypermethylation and/or loss of heterozygoty in hepatocellular carcinoma. PMID: 18559595
    39. Genome-wide significant association of the HHIP locus with lung function. The CHRNA 3/5 and the HHIP loci make a significant contribution to the risk of COPD. PMID: 19300482
    40. Results propose a role for Hedgehog-interacting protein as a structural decoy receptor for vertebrate Hedgehog. PMID: 19561609
    41. Results describe a series of crystal structures for the human Hedgehog-interacting protein ectodomain and Desert hedgehog (DHH) in isolation, as well as HHIP in complex with DHH (HHIP-DHH) and Sonic hedgehog (Shh) (HHIP-Shh), with and without Ca2+. PMID: 19561611
    42. show in mice and in human cartilage explants that pharmacological or genetic inhibition of Hh signaling reduces the severity of osteoarthritis and that RUNX2 potentially mediates this process by regulating ADAMTS5 expression PMID: 19915594

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane; Peripheral membrane protein. Secreted. Note=The last 22 C-terminal amino acids may participate in cell membrane attachment.; [Isoform 2]: Cytoplasm.
  • 蛋白家族:
    HHIP family
  • 組織特異性:
    Widely expressed in fetal and adult tissues. Highest expression in adult heart, liver and pancreas, and in fetal kidney.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 14866

    OMIM: 606178

    KEGG: hsa:64399

    STRING: 9606.ENSP00000296575

    UniGene: Hs.507991



主站蜘蛛池模板: 中文字幕第一区高清av| 国产精品又黄又爽又色无遮挡 | 国色天香中文字幕在线视频| 亚洲成av人综合在线观看| 一本久道久久综合狠狠躁av| 激情综合婷婷丁香五月情 | 人人添人人澡人人澡人人人人| 色爽黄1000部免费软件下载| 国色天香成人网| 国产在线视频天天综合网| 在线|国产精品女主播阳台| 国产精品免费看久久久无码 | 国产 在线 | 日韩| av无码人妻无码男人的天堂| a∨在线视频播放| www夜片内射视频在观看视频| 亚洲中文字幕无码中文字在线 | 日本一区二区更新不卡| 亚洲精品国产一区二区精华| 久久精品人人做人人爱爱漫画| 国产亚av手机在线观看| 日韩精品无码一区二区中文字幕| 未满十八勿入av网免费| 亚洲欧美日韩国产精品一区| 亚洲日韩欧洲乱码av夜夜摸| 五十路亲子中出在线观看| 女人和拘做受全程看视频| 国产成人综合日韩精品无码不卡 | 亚洲精品无码久久久久| 亚洲妇女行蜜桃av网网站| 国产在线精品欧美日韩电影| 在线成人精品国产区免费| 国产亚洲成av片在线观看 | 欧美 国产日韩 综合在线| 国产成人精品三级在线影院| 四虎成人精品永久在线视频 | 日韩国产网曝欧美第一页| 鲁鲁狠狠狠7777一区二区 | 奇米777四色成人影视| 国产精品白浆无码流出视频| 亚洲欧美中文日韩在线v日本|