在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HFE Antibody

  • 中文名稱:
    HFE兔多克隆抗體
  • 貨號:
    CSB-PA010323GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    HFE
  • 別名:
    dJ221C16.10.1 antibody; Hemochromatosis antibody; Hemochromatosis protein antibody; Hereditary hemochromatosis protein antibody; Hereditary hemochromatosis protein HLA H antibody; HFE 1 antibody; HFE antibody; HFE_HUMAN antibody; HFE1 antibody; HH antibody; High Fe antibody; HLA H antibody; HLA-H antibody; HLAH antibody; MGC:150812 antibody; MGC10379 antibody; MGC103790 antibody; MHC class I like protein HFE antibody; MVCD7 antibody; TFQTL2 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Human HFE
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
  • 基因功能參考文獻(xiàn):
    1. The Ala176Val mutation may have a possible role on the cause of hemochromatosis in a Japanese case PMID: 11446670
    2. mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites PMID: 11800564
    3. genotype and allele frequencies between neonates and referred patients for HFE molecular analysis PMID: 11809727
    4. Association between MHC class I gene HFE polymorphisms and longevity PMID: 11857056
    5. HFE gene implicated in this disorder has been identified on chromosome 6. the most prevalent mutation is a point mutation(histidine to aspartic acid)in iron overload has been controversial. PMID: 11869934
    6. A previously undescribed nonsense mutation of the HFE gene PMID: 11903354
    7. Distribution of HFE C282Y and H63D mutations in the Balearic Islands (NE Spain). PMID: 11903355
    8. results suggest that wild-type HFE negatively modulates the endocytic uptake of transferrin PMID: 11940510
    9. Frequency of the S65C mutation of HFE and iron overload in subjects heterozygous for C282Y. PMID: 11943417
    10. REVIEW:Characteristics of the C282Y mutation in childhood ALL, in contrast to other cancers, is male-specific, lacks a gene-dosage effect, and exhibits associations suggesting the involvement of another HLA-linked gene in leukemia susceptibility. PMID: 12002748
    11. Long term survival is excellent in C282Y homozygotes for the C282Y mutation of the hemochromatosis gene diagnosed and treated before the development of cirrhosis and diabetes PMID: 12045778
    12. Individuals with mutations in the HFE gene show very few hemochromatosis-related symptoms. PMID: 12059121
    13. The tighter association of the -467 polymorphism with the C282Y mutation is consistent with other data that suggest that the C282Y mutation has occurred relatively recently and that the H63D mutation is considerably older. PMID: 12064915
    14. HFE mutations do not confer an additional risk of hepatic fibrosis in patients with nonalcoholic steatohepatitis PMID: 12085358
    15. possession of the HFE gene 282Tyr allele may offer some protection against the development of Parkinson Disease. PMID: 12098643
    16. polymorphism and its relation to type 2 diabetes mellitus in the Czech population PMID: 12148086
    17. When combined with the C282Y mutation, the S65C mutation is associated with an increased risk of hemochromatosis. PMID: 12180078
    18. HFE has two mutually exclusive functions, binding to TfR1 in competition with Tf, or inhibition of iron release from macrophages. PMID: 12429850
    19. HFE mutations more common in patients than controls, and advanced degrees of fibrosis developed at younger ages with C282Y mutation. Patients with C282Y had higher mean hepatic iron concentrations, hepatic iron indices, and hepatic fibrosis scores. PMID: 12445428
    20. These results suggest that the apparent iron-deficient phenotype elicited by haemochromatosis protein (HFE) is not linked to beta(2)microglobulin insufficiency. PMID: 12464008
    21. an increased risk of osteoarthritis among individuals who are heterozygous for the C282Y HFE mutation. PMID: 12508400
    22. Genotyping of the C282Y and H63D substitutions in the HFE gene provides a satisfactory marker since these genotypes are associated with ~90% of herditary hemochromatosis. PMID: 12512743
    23. Subjects with any HFE gene mutation were more likely to have colon cancer than subjects with no HFE gene mutations. PMID: 12529348
    24. The presence of HFE mutations is independently associated with iron loading and advanced fibrosis in patients with compensated liver disease from chronic hepatitis C, especially after controlling for duration of disease. PMID: 12557137
    25. C282Y or H63D heterozygosity is an independent risk factor for liver fibrosis and cirrhosis in HCV infected individuals. Screening for HFE mutations should be considered in HCV infection. PMID: 12586300
    26. Results suggest that the H63D mutation in the hereditary hemochromatosis HFE gene may play a role in the pathogenesis of late onset type 2 diabetes. PMID: 12601293
    27. In patients with rheumatoid arthritis, 2/24 (8.34%) were found to be positive for the C282Y mutation in the case of heterozygosis compared with 3/24 (12.5%) of patients with spondylarthritis. PMID: 12635863
    28. The presence of TfR2 and absence of TfR1 suggests that HFE may serve a different function in platelets compared with the other HFE-positive cell types. PMID: 12656741
    29. Interacts with transferrin receptors in endosomes PMID: 12667138
    30. HFE C282Y and H63D are determinants of iron parameters in the elderly and will be effective in detecting individuals at high risk of hemochromatosis. PMID: 12673276
    31. HFE and APOE genotypes are different between Alzheimer's disease patients, high cognitive impairment and low cognitive impairment PMID: 12707938
    32. this study does not support the suggestion that H63D mutations may anticipate sporadic AD clinical presentation in susceptible individuals. PMID: 12714262
    33. trend for an increased frequency of H63D allele in centenarian women PMID: 12714263
    34. In a population of 1279 Caucasians with angiographically confirmed coronary status, there is no evidence of an association between the C282Y mutation in the haemochromatosis gene and prevalence of coronary artery disease and myocardial infarction PMID: 12746412
    35. The mild iron overload associated with heterozygosity for C282Y HFE mutation confers susceptibility to nonalcoholic fatty liver disease PMID: 12779071
    36. We see no evidence for over-representation of iron loading HFE alleles in type 2 diabetes mellitus PMID: 12783844
    37. study performed in two samples of genetically homogeneous patients and controls does not support the suggestion that HFE mutations may be associated with acute myocardial infarction in susceptible individuals PMID: 12850485
    38. REVIEW: C282Y mutant gene product failed to associate with 2-microglobulin and significantly reduced cell surface expression of the HFE-2m complex, thereby affecting the interaction with TfR and its interaction with transferrin. PMID: 9869618
    39. 871 healthy unrelated subjects in Poland were collected to assess the relevant frequencies. Each subject was genotyped for the C282Y and H63D mutations using a PCR-based protocol PMID: 11386022
    40. Overall, this increased understanding of the role of HFE in the immune response sets the stage for better treatment and management of hereditary hemochromatosis and other iron-related diseases, as well as of the immune defects related to this condition. PMID: 28474781
    41. Results show that cystic fibrosis (CF) patients who carry a HFE gene mutation, particularly the C282Y substitution, demonstrate accelerated lung function and worsening of disease suggesting that HFE C282Y mutation is associated with CF severity and progression. PMID: 30291871
    42. This study showed that the Iron related hemochromatosis (HFE) gene mutations in Friedreich Ataxia patients. PMID: 27814974
    43. p.Cys282Tyr homozygous women are diagnosed HFE Hemochromatosis at a later age than men, and thus corroborates the existence of a difference in the expression of this genotype between men and women. Nevertheless, these results do not confirm the protective effect typically attributed to pregnancy to explain the slower iron accumulation in women. PMID: 29454332
    44. HFE could be a potential susceptibility gene for isolated recurrent aphthous oral ulcers PMID: 28950260
    45. HFE mutation is associated with a lower level of aerobic capacity, even in the absence of iron accumulation. PMID: 29362711
    46. Three single nucleotide polymorphisms associated with iron regulation were genotyped in multiple sclerosis : two in the human hereditary hemochromatosis protein gene HFE: rs1800562 (C282Y mutation) and rs1799945 (H63D mutation), as well as the rs1049296 SNP in the transferrin gene (C2 mutation). We only observed a higher prevalence of TF-C2 in multiple sclerosis patients PMID: 29201641
    47. The HFE gene including both coding and boundary intronic regions were sequenced and polymorphisms were identified in 304 Brazilian individuals, encompassing healthy individuals and patients exhibiting hereditary or acquired iron overload. PMID: 28727322
    48. homozygosity for the HLA-A*03 allele significantly increases the risk of excessive iron loading in Norwegian p.C282Y homozygous male patients. PMID: 28678636
    49. genetic association studies in cohort of infants in Spain: Data suggest that serum hepcidin levels increase in infants during first year of life and are positively associated with iron status only in infants with wild-type HFE gene (not in infants with genetic polymorphisms C282Y, H63D, and S65C). PMID: 29404719
    50. HFE stability is pH-dependent. PMID: 27174123

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Hemochromatosis 1 (HFE1); Variegate porphyria (VP); Microvascular complications of diabetes 7 (MVCD7)
  • 亞細(xì)胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    MHC class I family
  • 組織特異性:
    Expressed in all tissues tested except brain.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4886

    OMIM: 176200

    KEGG: hsa:3077

    STRING: 9606.ENSP00000417404

    UniGene: Hs.233325



主站蜘蛛池模板: 日韩精品无码一区二区忘忧草| 亚洲国产精品久久久久秋霞影院| 亚洲爆乳无码一区二区三区| 亚洲成a∧人片在线观看无码| 国产成人理论无码电影网| 国语自产精品视频在线看| 美女露全乳无遮掩视频| 亚洲 综合 欧美在线视频| 一本清日本在线视频精品| 暖暖视频日本| 国产精品你懂的在线播放| 粗壮挺进人妻水蜜桃成熟漫画| 亚洲色无码专区在线观看| 蜜臀精品无码av在线播放| 成人性生交大片免费看r老牛网站| 日本亚洲欧美高清专区vr专区| 国产精品人妻一码二码| 99久久婷婷国产综合精品青草免费| 特级无码毛片免费视频播放▽| 亚洲日本中文字幕乱码在线| 夫妻免费无码v看片| 国产乱子伦视频一区二区三区| 日韩国产亚洲欧美中国v| 无人去码一码二码三码区| 国内精品人妻无码久久久影院蜜桃 | 偷偷色噜狠狠狠狠的777米奇| 午夜理论片yy8860y影院| 免费看国产精品3a黄的视频| 日韩精品久久久免费观看| 爱做久久久久久| 人妻少妇精品视频无码综合 | 中出人妻中文字幕无码| 亚洲另类无码专区丝袜| 中国xxx农村性视频| 国产精品久久久久久超碰| 全部av―极品视觉盛宴| 极品少妇被猛得白浆直喷白浆小说| 欧美老熟妇乱子| 亚洲第一综合天堂另类专| 边啃奶头边躁狠狠躁玩爽在水里面| 久久精晶国产99久久6|