在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HES6 Antibody

  • 中文名稱:
    HES6兔多克隆抗體
  • 貨號:
    CSB-PA002904
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of HeLa cells using HES-6 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    HES6
  • 別名:
    HES6 antibody; BHLHB41 antibody; Transcription cofactor HES-6 antibody; C-HAIRY1 antibody; Class B basic helix-loop-helix protein 41 antibody; bHLHb41 antibody; Hairy and enhancer of split 6 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the N-terminal region of Human HES-6.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation.
  • 基因功能參考文獻:
    1. High HES6 expression is associated with metastasis in colorectal cancer. PMID: 30015909
    2. prostate cancer-specific up-regulation of NOTCH3 and HES6, is reported. PMID: 25864518
    3. HES6 mutations are associated with castration resistant and androgen independent tumors in prostate cancer. PMID: 25006183
    4. HES6 is up-regulated in aggressive human prostate cancer and drives tumour growth by enhancing the transcriptional activity of the AR, which is preferentially directed to a regulatory network enriched for transcription factors such as E2F1. PMID: 24737870
    5. HES6 contributes to the pathogenesis of alveolar rhabdomyosarcoma by enhancing both proliferation and cell motility. PMID: 22982728
    6. HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation. PMID: 21785461
    7. Data suggest that Hes-6 is a potential oncogene overexpressed in breast cancer, with a tumor-promoting and proliferative function. Hes-6 is a novel estrogen-regulated gene in breast cancer cells. PMID: 19891787
    8. Differentially expressed in metastatic colon carcinoma PMID: 12957362
    9. Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity. PMID: 12972610
    10. Here, we show that WRPW motif deletion mutant Hes6 protein is substantially stabilized in comparison to the full length protein and that the enhanced stability is due to its resistance to proteasomal degradation. PMID: 15896295
    11. Hes6 overexpression using a retroviral vector led to a decrease in Hes1 levels, an increase in beta-cell transcription factors and partial restoration of insulin expression PMID: 17300753
    12. Increased expression of Notch3, Jagged1, Hes1, and Hes6 gene transcripts were observed during differentiation of cultured human skeletal muscle cells. PMID: 17301032
    13. ATOH1 activates HES6 transcription through binding to three clustered E boxes of its promoter PMID: 17826772
    14. the Hes6-CBP complex in PML-NB may influence the proliferation of cells via p53-dependent and -independent pathways. PMID: 18160400
    15. These four variants were tested for association with mood disorder diagnosis or antidepressant response in a family study of depression, but no significant associations were observed. PMID: 19481584

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 數據庫鏈接:

    HGNC: 18254

    OMIM: 610331

    KEGG: hsa:55502

    STRING: 9606.ENSP00000272937

    UniGene: Hs.42949



主站蜘蛛池模板: 午夜人妻久久久久久久久| 亚洲欧美日韩国产自偷| 天堂а√在线中文在线新版 | 国内自拍视频一区二区三区| 国产精品无码一区二区在线a片| 亚洲综合在线另类色区奇米| 一区二区三区高清日本vr| 国产成人人综合亚洲欧美丁香花| 爽到高潮无码视频在线观看| 极品少妇xxxx精品少妇偷拍| 热久久美女精品天天吊色| 精品国产免费第一区二区三区| 精品日韩亚洲欧美高清a| 欧美人与性动交g欧美精器| 亚洲精品456在线播放| 18禁勿入网站入口永久| 无码精品人妻一区二区三区av | 露脸叫床粗话东北少妇| 波多野结衣在线精品视频| 亚洲欧美国产另类va| 亚洲国产精品自在拍在线播放蜜臀| 欧美潮喷少妇100| 夜夜影院未满十八勿进| 无码精品a∨在线观看无广告| 亚洲精品久久yy5099| 欧美在线观看免费专区| 日韩国产成人无码av毛片| 不卡无码av一区二区三区| 亚洲乱码卡一卡二卡新区仙踪木木| 国产精品无码嫩草地址更新| 中出内射颜射骚妇| 在线亚洲视频网站www色| 四虎永久在线精品8848a| 性按摩玩人妻hd中文字幕| 久久99精品久久久久久噜噜| 国厂精品114福利电影免费| 久久久久蜜桃精品成人片公司 | 久久99精品九九九久久婷婷| 久久国产精品精品国产色婷婷| 亚洲和欧洲一码二码区别7777| 九九九精品成人免费视频|