在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HES6 Antibody

  • 中文名稱:
    HES6兔多克隆抗體
  • 貨號:
    CSB-PA002904
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of HeLa cells using HES-6 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    HES6
  • 別名:
    HES6 antibody; BHLHB41 antibody; Transcription cofactor HES-6 antibody; C-HAIRY1 antibody; Class B basic helix-loop-helix protein 41 antibody; bHLHb41 antibody; Hairy and enhancer of split 6 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the N-terminal region of Human HES-6.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation.
  • 基因功能參考文獻:
    1. High HES6 expression is associated with metastasis in colorectal cancer. PMID: 30015909
    2. prostate cancer-specific up-regulation of NOTCH3 and HES6, is reported. PMID: 25864518
    3. HES6 mutations are associated with castration resistant and androgen independent tumors in prostate cancer. PMID: 25006183
    4. HES6 is up-regulated in aggressive human prostate cancer and drives tumour growth by enhancing the transcriptional activity of the AR, which is preferentially directed to a regulatory network enriched for transcription factors such as E2F1. PMID: 24737870
    5. HES6 contributes to the pathogenesis of alveolar rhabdomyosarcoma by enhancing both proliferation and cell motility. PMID: 22982728
    6. HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation. PMID: 21785461
    7. Data suggest that Hes-6 is a potential oncogene overexpressed in breast cancer, with a tumor-promoting and proliferative function. Hes-6 is a novel estrogen-regulated gene in breast cancer cells. PMID: 19891787
    8. Differentially expressed in metastatic colon carcinoma PMID: 12957362
    9. Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity. PMID: 12972610
    10. Here, we show that WRPW motif deletion mutant Hes6 protein is substantially stabilized in comparison to the full length protein and that the enhanced stability is due to its resistance to proteasomal degradation. PMID: 15896295
    11. Hes6 overexpression using a retroviral vector led to a decrease in Hes1 levels, an increase in beta-cell transcription factors and partial restoration of insulin expression PMID: 17300753
    12. Increased expression of Notch3, Jagged1, Hes1, and Hes6 gene transcripts were observed during differentiation of cultured human skeletal muscle cells. PMID: 17301032
    13. ATOH1 activates HES6 transcription through binding to three clustered E boxes of its promoter PMID: 17826772
    14. the Hes6-CBP complex in PML-NB may influence the proliferation of cells via p53-dependent and -independent pathways. PMID: 18160400
    15. These four variants were tested for association with mood disorder diagnosis or antidepressant response in a family study of depression, but no significant associations were observed. PMID: 19481584

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 數據庫鏈接:

    HGNC: 18254

    OMIM: 610331

    KEGG: hsa:55502

    STRING: 9606.ENSP00000272937

    UniGene: Hs.42949



主站蜘蛛池模板: 青青草av国产精品| 国产精品视频一区二区三区无码| 日本人妻人人人澡人人爽| 国产女精品视频网站免费| 亚洲一区二区三区高清在线看 | 国产欧美精品一区二区色综合| 欧美颜射内射中出口爆在线| 高潮内射免费看片| 成人亚洲一区无码久久| 久久精品人人做人人爽97| 色婷婷综合久久久久中文 | 久久99精品久久久久久2021| 亚洲娇小与黑人巨大交| 亚洲综合天堂av网站在线观看| 久久久中文久久久无码| 免费va国产高清大片在线| 亚洲欧美另类精品二区| 五十路熟妇亲子交尾| 国内精品久久久久影视老司机| 人人妻人人爽日日人人| 在线观看肉片av网站免费| 欧美黑人又粗又大高潮喷水 | 最近2019中文字幕大全第二页| 国产精品丝袜久久久久久不卡| 免费看美女部位隐私网站| 2020国产激情视频在线观看| 欧美人与物videos另类| 女人18片毛片60分钟| 白嫩无码人妻丰满熟妇啪啪区百度| 欧美丰满老熟妇乱叫| 国产精品视频永久免费播放| 国产精品无码av天天爽| 久久精品亚洲乱码伦伦中文| 欧美丰满老妇性猛交| 么公的好大好硬好深好爽视频 | 少妇真人直播免费视频| 日产一区日产2区| 欧美猛少妇色xxxxx猛交| 人妻精品人妻无码一区二区三区 | 免费国产线观看免费观看| 国产sm调教视频在线观看|