在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HCN2 Antibody

  • 中文名稱:
    HCN2兔多克隆抗體
  • 貨號:
    CSB-PA040231
  • 規(guī)格:
    ¥1090
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    BCNG-2 antibody; BCNG2 antibody; Brain cyclic nucleotide gated channel 2 antibody; Brain cyclic nucleotide-gated channel 2 antibody; HAC1 antibody; Hcn2 antibody; HCN2_HUMAN antibody; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human HCN2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.
  • 基因功能參考文獻:
    1. beta2-adrenoceptors alone strongly enhanced the activity of HCN2 channels, and co-expression of odorant receptors further diversified the HCN2 channel activity. PMID: 29054409
    2. TRIP8b competes with a portion of the cAMP-binding site or distorts the binding site by making interactions with the binding pocket, thus acting predominantly as a competitive antagonist that inhibits the cyclic-nucleotide dependence of HCN channels. PMID: 28864772
    3. HCN2 has a role in maturation and processing of the amyloid precursor protein PMID: 28017718
    4. promoter methylation status does not appear to be a major determinant of HCN2 expression in normal and adenoid cystic carcinoma ( ACC )tissues. HCN2 hypomethylation is a biomarker of ACC and may play an important role in the carcinogenesis of ACC. PMID: 27212063
    5. Aged patients with sinus rhythm exhibited significantly higher expression levels of HCN2 and HCN4 channel mRNA and protein (P<0.05), but significantly lower expression levels of miR1 and 133, compared with those of adult patients with sinus rhythm. PMID: 26005035
    6. Data show that Rab8b-interacting protein TRIP8b does not compete with cyclic AMP for the same binding region of hyperpolarization activated cyclic nucleotide gated potassium channel 2 (HCN2). PMID: 25197093
    7. N-glycosylation is not required for HCN2 channels to function. PMID: 25423599
    8. Thermal hyperalgesia under chronic inflammatory conditions is mediated by HCN2 channels. PMID: 24525276
    9. Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner. PMID: 24324597
    10. HCN2 polymorphism may play a role in chronic inflammatory periodontitis but not in peri-implantitis. PMID: 23907424
    11. LBB-injected HCN2/SkM1 potentially provides a more clinically suitable biological pacemaker strategy than other reported constructs. This superiority is attributable to the more negative AP threshold and injection into the LBB PMID: 23395072
    12. HCN2 channels make an important contribution to the maintenance of spontaneous burst activity in embryonic cortical neuron cultures. PMID: 22094222
    13. This is the first evidence in humans for a single-point, homozygous loss-of-function mutation in HCN2 potentially associated with generalized epilepsy with recessive inheritance. PMID: 22131395
    14. Genetic analysis in 48 Sudden unexpected death in epilepsy cases identified six novel and three previously reported nonsynonymous (amino acid changing) variants in HCN1 , HCN2, HCN3 and HCN4. PMID: 21615589
    15. HCN4 activates substantially slower than HCN2 and with a half-maximum activation voltage approximately equal 10 mV less negative, both isoforms activate more positively in myocytes suggesting cell-type specificity PMID: 12194012
    16. activation of the fast channel HCN2 is dependent on the S1 segment PMID: 12813043
    17. HCN1 and HCN2 expression were measured using in situ hybridization and immunocytochemistry in hippocampi; the expression of HCN isoforms is dynamically regulated in human as well as in experimental hippocampal epilepsy PMID: 12890777
    18. Native I(f) channels in atrial myocardium are heteromeric complexes composed of HCN4 and/or HCN2. PMID: 15687126
    19. Mutations of a putative cyclic-nucleotide-binding domain (CNBD) can disrupt the function of the hyperpolarization-activated cyclic-nucleotide-gated channel (HCN2). PMID: 15961404
    20. an intact F-actin cytoskeleton is a prerequisite for the swelling-induced HCN2 current PMID: 15980171
    21. With computer modelling, we show that in channels with relatively slow opening kinetics and fast mode-shift transitions, such as HCN2 and HCN4 channels, the mode shift effects are not readily observable, except in the tail kinetics. PMID: 16777944
    22. Noise analysis on macroscopic currents revealed fluctuations whose magnitudes were systematically larger than predicted from the actual single channel current size, consistent with cooperativity between single HCN channels. PMID: 17043149
    23. Several functional variants were identified including the amino acid substitution R527Q in HCN2 exon 5. HCN2 channels containing the R527Q variant demonstrated a trend towards a decreased slope of the conductance-voltage relation. PMID: 17931874
    24. RPTPalpha plays a critical role in HCN channel function via tyrosine dephosphorylation PMID: 18768480

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Potassium channel HCN family
  • 組織特異性:
    Highly expressed throughout the brain. Detected at low levels in heart.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4846

    OMIM: 602781

    KEGG: hsa:610

    STRING: 9606.ENSP00000251287

    UniGene: Hs.124161



主站蜘蛛池模板: 92精品成人国产在线观看 | 热re99久久6国产精品免费| 曰批免费视频播放免费直播| 亚洲精品国产一区二区三| 亚洲丁香五月激情综合| 国产精品 中文字幕 亚洲 欧美 | 亚洲欧美日韩中文在线制服| 韩国三级中文字幕hd| 国产suv精品一区二区| 看免费真人视频网站| 一 级做人爱全视频在线看| 欧美成人一区二区三区在线视频| 97人妻天天爽夜夜爽二区| 国产a精彩视频精品视频下载| 一本大道久久东京热av| 同性女女黄h片在线播放| 无码日日模日日碰夜夜爽| 国产精品线路一线路二| 欧美老熟妇乱子| 性色欲网站人妻丰满中文久久不卡| 综合 欧美 亚洲日本| 2018av天堂在线视频精品观看| 熟妇人妻无乱码中文字幕真矢织江| 少妇饥渴偷公乱av在线观看涩爱| 久久国产免费福利永久| 国产97色在线 | 欧洲| 久久精品人人做人人爽| 免费观看亚洲人成网站| 亚洲熟悉妇女xxx妇女av| 国产乱子伦视频在线播放| 无码专区亚洲综合另类| 精品国产福利久久久| 久久综合九色综合欧洲98| 无套内射在线观看theporn| 9色国产深夜内射| 成 人影片 免费观看| 特黄做受又硬又粗又大视频小说| 亚洲精品成人久久电影网| 天堂在线.www天堂在线资源| 成人丝袜激情一区二区| 国产suv精品一区|