在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HCN2 Antibody

  • 中文名稱:
    HCN2兔多克隆抗體
  • 貨號:
    CSB-PA040231
  • 規(guī)格:
    ¥1090
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    BCNG-2 antibody; BCNG2 antibody; Brain cyclic nucleotide gated channel 2 antibody; Brain cyclic nucleotide-gated channel 2 antibody; HAC1 antibody; Hcn2 antibody; HCN2_HUMAN antibody; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human HCN2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.
  • 基因功能參考文獻:
    1. beta2-adrenoceptors alone strongly enhanced the activity of HCN2 channels, and co-expression of odorant receptors further diversified the HCN2 channel activity. PMID: 29054409
    2. TRIP8b competes with a portion of the cAMP-binding site or distorts the binding site by making interactions with the binding pocket, thus acting predominantly as a competitive antagonist that inhibits the cyclic-nucleotide dependence of HCN channels. PMID: 28864772
    3. HCN2 has a role in maturation and processing of the amyloid precursor protein PMID: 28017718
    4. promoter methylation status does not appear to be a major determinant of HCN2 expression in normal and adenoid cystic carcinoma ( ACC )tissues. HCN2 hypomethylation is a biomarker of ACC and may play an important role in the carcinogenesis of ACC. PMID: 27212063
    5. Aged patients with sinus rhythm exhibited significantly higher expression levels of HCN2 and HCN4 channel mRNA and protein (P<0.05), but significantly lower expression levels of miR1 and 133, compared with those of adult patients with sinus rhythm. PMID: 26005035
    6. Data show that Rab8b-interacting protein TRIP8b does not compete with cyclic AMP for the same binding region of hyperpolarization activated cyclic nucleotide gated potassium channel 2 (HCN2). PMID: 25197093
    7. N-glycosylation is not required for HCN2 channels to function. PMID: 25423599
    8. Thermal hyperalgesia under chronic inflammatory conditions is mediated by HCN2 channels. PMID: 24525276
    9. Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner. PMID: 24324597
    10. HCN2 polymorphism may play a role in chronic inflammatory periodontitis but not in peri-implantitis. PMID: 23907424
    11. LBB-injected HCN2/SkM1 potentially provides a more clinically suitable biological pacemaker strategy than other reported constructs. This superiority is attributable to the more negative AP threshold and injection into the LBB PMID: 23395072
    12. HCN2 channels make an important contribution to the maintenance of spontaneous burst activity in embryonic cortical neuron cultures. PMID: 22094222
    13. This is the first evidence in humans for a single-point, homozygous loss-of-function mutation in HCN2 potentially associated with generalized epilepsy with recessive inheritance. PMID: 22131395
    14. Genetic analysis in 48 Sudden unexpected death in epilepsy cases identified six novel and three previously reported nonsynonymous (amino acid changing) variants in HCN1 , HCN2, HCN3 and HCN4. PMID: 21615589
    15. HCN4 activates substantially slower than HCN2 and with a half-maximum activation voltage approximately equal 10 mV less negative, both isoforms activate more positively in myocytes suggesting cell-type specificity PMID: 12194012
    16. activation of the fast channel HCN2 is dependent on the S1 segment PMID: 12813043
    17. HCN1 and HCN2 expression were measured using in situ hybridization and immunocytochemistry in hippocampi; the expression of HCN isoforms is dynamically regulated in human as well as in experimental hippocampal epilepsy PMID: 12890777
    18. Native I(f) channels in atrial myocardium are heteromeric complexes composed of HCN4 and/or HCN2. PMID: 15687126
    19. Mutations of a putative cyclic-nucleotide-binding domain (CNBD) can disrupt the function of the hyperpolarization-activated cyclic-nucleotide-gated channel (HCN2). PMID: 15961404
    20. an intact F-actin cytoskeleton is a prerequisite for the swelling-induced HCN2 current PMID: 15980171
    21. With computer modelling, we show that in channels with relatively slow opening kinetics and fast mode-shift transitions, such as HCN2 and HCN4 channels, the mode shift effects are not readily observable, except in the tail kinetics. PMID: 16777944
    22. Noise analysis on macroscopic currents revealed fluctuations whose magnitudes were systematically larger than predicted from the actual single channel current size, consistent with cooperativity between single HCN channels. PMID: 17043149
    23. Several functional variants were identified including the amino acid substitution R527Q in HCN2 exon 5. HCN2 channels containing the R527Q variant demonstrated a trend towards a decreased slope of the conductance-voltage relation. PMID: 17931874
    24. RPTPalpha plays a critical role in HCN channel function via tyrosine dephosphorylation PMID: 18768480

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Potassium channel HCN family
  • 組織特異性:
    Highly expressed throughout the brain. Detected at low levels in heart.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4846

    OMIM: 602781

    KEGG: hsa:610

    STRING: 9606.ENSP00000251287

    UniGene: Hs.124161



主站蜘蛛池模板: 狠狠色婷婷久久综合频道日韩| 国产成人无码激情视频| 五月天精品视频在线观看| 婷婷色香五月综合激激情| 女人与拘性猛交视频| 九九九国产精品成人免费视频| 国产午夜无码片免费| 超清精品丝袜国产自在线拍| a在线视频v视频| 亚洲精品亚洲人成人网| 火箭视频在线观看精品| 天堂在线最新版资源www| 亚洲伊人成综合网2222| 国产精品久久久久9999爆乳| 和岳每晚弄的高潮嗷嗷叫视频| 亚洲中文字幕无码mv| 一区二区视频日韩免费| 最近日本免费观看高清视频| 亚洲中文字幕无码中文字在线 | 午夜大片免费男女爽爽影院| 特级av毛片免费观看| 在线不卡日本v一区二区| 亚洲色欲色欲77777小说网站| 免费很黄无遮挡的视频| 国模吧无码一区二区三区| 国产乱子伦精品视频| 无码h肉动漫在线观看免费| 67pao国产成视频永久免费| 免费三级网站| 成年男人裸j照无遮挡无码| 午夜无码精品国产片| 无码少妇一区二区性色av | 欧美va亚洲va在线观看日本| 人妻老妇乱子伦精品无码专区| 天天躁日日躁狠狠躁性色avq| 欧美乱妇狂野欧美在线视频| 中文字幕无码日韩欧免费软件| 国产成人午夜精品影院| 女人高潮内射99精品 | 亚洲午夜无码极品久久| 在线天堂资源www中文|