在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HBP1 Antibody

  • 中文名稱:
    HBP1兔多克隆抗體
  • 貨號(hào):
    CSB-PA097019
  • 規(guī)格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from COS-7 cells, using HBP1 antibody.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) HBP1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    HBP1
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from Internal of Human HBP1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.
  • 基因功能參考文獻(xiàn):
    1. Study shows that RORbeta is a transcriptional enhancer of inhibitor HBP1 of the Wnt pathway. NRIP2 prevents RORbeta to bind with downstream HBP1 promoter regions and reduces the transcription of HBP1. These results provide evidence that interactions between NRIP2, RORbeta, and HBP1 mediate a new mechanism for CCIC self-renewal via the Wnt activity. PMID: 28137278
    2. Low HBP1 expression is associated with invasive oral cancer. PMID: 28099936
    3. induced premature senescence and apoptosis. Furthermore, the Pim-1-HBP1 positive feedback loop exerts its effect by regulating the senescence markers DNMT1 and p16 and the apoptosis marker Bax. The Pim-1-HBP1 axis thus constitutes a novel checkpoint pathway critical for the inhibition of tumorigenesis. PMID: 28348080
    4. miR155 may contribute to the progression and growth of Colorectal carcinomaby enhancing the Wnt/betacatenin pathway in an HBP1associated mechanism. PMID: 26780942
    5. Data suggest HMG-box transcription factor (HBP1) as a target in prostate cancer radiotherapy. PMID: 26942107
    6. Data show that HMG-box transcription factor 1 protein HBP1-mediated elevation of CDK inhibitor p21 through the Mdm2/p53 and TCF4/EZH2 pathways contributes to both cellular senescence and tumor inhibition. PMID: 27129219
    7. All trans-retinoic acid can reverse the suppressive effect of MED28 on HBP1 and E-cadherin and inactivate the Wnt/beta-catenin pathway in colorectal cancer, suggesting a protective effect of ATRA against colorectal cancer. PMID: 26660958
    8. HBP1-mediated Wnt signaling is involved with the role of miR-155 in osteosarcoma progression. PMID: 25666090
    9. Hbp1 plays a crucial role in regulating the timing of cortical neurogenesis by elongating the cell cycle and that it is essential for normal cortical development. PMID: 26041766
    10. HBP1 is a suppressor of cancer progression and a regulator of CTNNB1 gene transcription. PMID: 24895061
    11. miR-96/HBP1/Wnt/beta-catenin regulatory circuitry promotes the proliferation of glioma cell PMID: 24931370
    12. HBP1 is a novel target of the PI3K/FOXO pathway and controls cell proliferation in response to growth factors. PMID: 24762137
    13. acetylation of TCF4E is a novel regulatory mechanism that diversifies the transcriptional output of Wnt/beta-catenin signaling PMID: 23613959
    14. HBP1 represses the DNMT1 gene through binding a high-affinity site in the DNMT1 promoter. PMID: 23249948
    15. Cis-acting regulatory polymorphisms acting on HBP1 contribute to the osteoarthritis association signal at chromosome 7q22. PMID: 22586168
    16. miR-17-5p plays an important role in breast cancer cell invasion and migration by suppressing HBP1 and subsequent activation of Wnt/beta-catenin PMID: 20505989
    17. HBP1 targets P16(INK4A), upregulating its expression and consequently is involved in Ras-induced premature senescence. PMID: 20581871
    18. HBP1 directly inhibits MIF gene transcription, which is overexpressed in prostatic cancer. PMID: 20383199
    19. HBP1 binds c-Myc in cells, and expression of HBP1 inhibits c-Myc transactivational activity at least partly by preventing c-Myc binding to target gene promoters. PMID: 20008325
    20. NMR study of the AXH domain PMID: 14872137
    21. Results indicate that HBP1 may contribute to the regulation of NADPH oxidase-dependent superoxide production through transcriptional repression of the p47phox gene. PMID: 15024088
    22. HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations PMID: 15235594
    23. in myeloid cells HBP1 may serve as a tumor suppressor and a general differentiation inducer and may synergize with chemical differentiating agents to enhance lineage-specific differentiation PMID: 16179914
    24. Transgenic mice overexpressing HBP1 exhibit altered thymus cellularity and decreased thymocyte development. PMID: 16210625
    25. EGCG blocks Wnt signaling by inducing the HBP1 transcriptional repressor and inhibits aspects of invasive breast cancer PMID: 16495219
    26. these studies highlight p38 MAPK, HBP1, and RB as important components for a premature-senescence pathway with possible clinical relevance to breast cancer. PMID: 16966377
    27. HBP1 transcriptional repressor alterations are associated with invasive breast cancer PMID: 17616670
    28. HBP1 regulates the cell cycle in liver regeneration and provides evidence for a role in tissue maintenance. PMID: 11486012
    29. HBP1 is a suppressor of Wnt signalling and lies in a region that is mutated in cancer. PMID: 11500377
    30. HBP1 was isolated as a cell cycle inhibitor and HMG-box transcriptional repressor. PMID: 9030690

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 23200

    KEGG: hsa:26959

    STRING: 9606.ENSP00000222574

    UniGene: Hs.162032



主站蜘蛛池模板: 女人被男人爽到呻吟的视频| 朋友的丰满人妻中文字幕| 亚洲综合av在线在线播放| 中文在线а√天堂| 亚洲伊人久久大香线蕉综合图片| 亚洲女人色综合小说| 真人床震高潮全部视频免费| 肥老熟妇伦子伦456视频| 国产精品自在拍在线播放| 吃奶摸下高潮60分钟免费视频| 国产交换配偶在线视频| 成人aaa片一区国产精品| 国产又色又爽又刺激视频| 最新亚洲伦理中文字幕| 国产乱了伦视频大全亚琴影院| 中文无码一区二区不卡αv| 精品无码av无码专区| 国产一卡2卡3卡四卡精品国色无边 | 在线|国产精品女主播阳台| 嫩草伊人久久精品少妇av| 国产成人亚洲综合无码精品| 四虎永久在线高清国产精品| 欧美肥臀大屁股magnet| 麻豆一区二区99久久久久| 少妇厨房愉情理9仑片视频| 久久综合给合久久国产免费| 国产麻豆精品福利在线观看| 国产成人精品日本亚洲专区61| 女人色极品影院| 亚洲女人色综合小说| 欧美精品videossex少妇| 欧美性受xxxx黑人xyx性爽 | 亚洲超清无码制服丝袜无广告| 久久久99久久久国产自输拍| 夜鲁鲁鲁夜夜综合视频欧美| 亚洲中文字幕在线无码一区二区 | 日韩人妻一区二区三区蜜桃视频| 天天躁日日摸久久久精品| 精品久久久无码中文字幕一丶| 韩国三级中文字幕hd| 四虎永久在线精品无码视频|