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HBE1 Antibody

  • 中文名稱:
    HBE1兔多克隆抗體
  • 貨號:
    CSB-PA010153GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Epsilon-globin antibody; HBE_HUMAN antibody; HBE1 antibody; Hemoglobin epsilon chain antibody; Hemoglobin subunit epsilon antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human HBE1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin.
  • 基因功能參考文獻:
    1. epsilon-globin expression is regulated by SUV4-20h1. PMID: 26802048
    2. These data indicate that HP1-gamma is a novel epigenetic repressor of epsilon-globin gene expression. PMID: 28154185
    3. Fetal varepsilon-globin gene expression is significantly greater than adult expression and is increased in maternal plasma compared to non-pregnant samples. PMID: 27002261
    4. findings indicate the Xmn1-Ggamma polymorphism is likely to be one factor that influences the production of HbF in beta-thalassemia/HbE patients, but not in homozygous HbE patients PMID: 25043956
    5. Data indicate that Myb and BCL11A cooperate with DNMT1 to achieve developmental repression of embryonic and fetal beta-like human transgenic globin genes in the adult erythroid environment. PMID: 24371119
    6. Data indicate that in embryonic stem cells (hESCs)-derived erythroblasts where both epsilon and gamma globin were active, epsilon globin was immediately silenced upon transfer, whereas gamma globin continued to be expressed for months. PMID: 23993951
    7. A plasma proteome analysis is performed to identify differentially expressed proteins compared between normal subjects and patients with mild and severe forms of beta-thalassemia/hemoglobin E (Hb E). PMID: 23161390
    8. In the present study, involving the characterization of mutations in transfusion-dependent thalassemia in the Gwalior-Chambal region of Central India, Hb E [beta26(B8)Glu-->Lys, GAG>AAG] was found in high frequency. PMID: 22738610
    9. the observed in vivo RBC mild oxidative stress arises, at least in part, from the molecular consequences of the HbE mutation. PMID: 22260787
    10. investigation of interaction of HbE w/ other abnormal hemoglobins found in India isolated by cation exchange chromatography; interactions complicate Hb isolation and thus diagnosis of hemoglobinopathies/beta-thalassemias in heterozygous patients PMID: 21986214
    11. Erythroblasts from beta-thalassemia/Hb E patients only show activation of the unfolded protein response pathway in response to internal stress, whereas normal erythroblasts respond to both internal and external stress. PMID: 20015891
    12. patients with hemoglobin Ebeta thalassemia have a significant decrease in the oxygen affinity of their hemoglobin, that is an increased P(50) value, in response to anemia. PMID: 20833979
    13. The frequency of the Ggamma-158(C-->T) polymorphism was relatively high in Southern Chinese patients with HbE/beta-thalassemia major. PMID: 20822527
    14. Crystallization and X-ray structure of this protein, isolated from blood of beta-thalassemic patients PMID: 12659864
    15. HbE carrier status has been shown to confer protection against Plasmodium falciparum malaria PMID: 15114532
    16. Genomic and phylogenetic footprinting at the epsilon-globin silencer region in human cells PMID: 15157738
    17. The crystal structure of HbE at 1.74 angstrom resolution in R2 state is used to provide probable explanations of the thermal stability and instability of HbE. PMID: 15449937
    18. Mutation screening identified no sequence variations apart from the expected 5'epsilon /HincII polymorphism, suggesting that genomic alterations in the HBE1 gene are most likely incompatible with normal erythropoiesis and proper embryonic development PMID: 16432873
    19. results suggest in the context of the whole beta-globin locus, other proximal & upstream epsilon promoter elements & competition by downstream globin genes contribute to silencing of epsilon-globin in cells of definitive erythropoiesis [epsilon-globin] PMID: 16514181
    20. We discussed these results in the context of intergenic transcription and chromatin opening in the beta-globin gene cluster. PMID: 16620781
    21. The epsilon-globin mRNA is modestly unstable in immature, transcriptionally active erythroid cells, but that this characteristic has relatively little impact on the accumulation of epsilon-globin mRNA at subsequent stages of terminal differentiation. PMID: 17003365
    22. The epsilon-globin gene differs in its distance sensitivity to the locus control region from the other beta-like globin genes, which is, at least in part, determined by the transcription factor EKLF. PMID: 17548470
    23. the HbA/HbE polymorphism would not be a major genetic factor influencing the onset of cerebral malaria in Thailand. PMID: 18787944
    24. The slightly increased levels of Hb A(2), 3.5% +/- 0.4%, which is shown in the carriers of Hb E, confirm that Hb E is the silent phenotype of beta(+)-thalassemia. PMID: 18940720
    25. It is necessary to perform a comprehensive DNA analysis for alpha-thalassemia in cases of homozygous HbE when their partner is suspected of having alpha-thalassemia 1 gene. PMID: 19323016

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  • 蛋白家族:
    Globin family
  • 組織特異性:
    Red blood cells.
  • 數據庫鏈接:

    HGNC: 4830

    OMIM: 142100

    KEGG: hsa:3046

    STRING: 9606.ENSP00000292896

    UniGene: Hs.655195



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