在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HAT1 Antibody

  • 中文名稱:
    HAT1兔多克隆抗體
  • 貨號:
    CSB-PA010143GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    HAT 1 antibody; hat1 antibody; HAT1_HUMAN antibody; Histidine aminotransferase 1 antibody; Histone acetyltransferase 1 antibody; Histone acetyltransferase 1 antibody; Histone acetyltransferase type B catalytic subunit antibody; KAT1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human HAT1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac). Drives H4 production by chromatin binding to support chromatin replication and acetylation. Since transcription of H4 genes is tightly coupled to S-phase, plays an important role in S-phase entry and progression. Promotes homologous recombination in DNA repair by facilitating histone turnover and incorporation of acetylated H3.3 at sites of double-strand breaks. In addition, acetylates other substrates such as chromatin-related proteins. Acetylates also RSAD2 which mediates the interaction of ubiquitin ligase UBE4A with RSAD2 leading to RSAD2 ubiquitination and subsequent degradation.; (Microbial infection) Contributes to hepatitis B virus (HBV) replication by acetylating histone H4 at the sites of 'Lys-5' and 'Lys-12' on the covalently closed circular DNA (cccDNA) minichromosome leading to its accumulation within the host cell.
  • 基因功能參考文獻:
    1. The expression of HAT1 and MYST1, did not differ between drug-sensitive and -resistant cells PMID: 18458078
    2. Human histone acetyltransferase 1 (Hat1) acetylates lysine 5 of histone H2A in vivo. PMID: 24682716
    3. The high-resolution crystal structure of a Hat1p/Hat2p/CoA/H4 peptide complex was solved and it was found that the H4 tail interacts with both Hat1p and Hat2p, by which substrate recruitment is facilitated. It was discovered that H3 N-terminal peptides can bind to the Hat2p WD40 domain. PMID: 24835250
    4. Signalling from Toll-like or TNF-alpha receptors triggers the calcium/calmodulin-dependent protein kinase (CaMK2) to activate histone acetyltransferase-1 (HAT1), which then acetylates the transcriptional regulator PLZF. Acetylation of PLZF promotes the assembly of a repressor complex incorporating HDAC3 and the NF-kappa B p50 subunit that limits the NF-kappa B response. PMID: 25865065
    5. HAT1 is involved in the STAT5 binding to the Bcl2L12 promoter. HAT1 increased the expression of Bcl2L12. Bcl2L12 mediated the effects of HAT1 on suppressing NPC cell apoptosis. Absorption of the HAT1 shRNA plasmid-carrying liposomes induced NPC cell apoptosis. In conclusion, inhibition of HAT1 can induce NPC cell apoptosis via increasing Bcl2L12 expression, which can be a potential therapy for NPC treatment. PMID: 29621521
    6. HAT1 was upregulated in hepatocellular carcinoma.HAT1 acts as an oncogenic protein promoting cell proliferation and inducing cisplatin resistance in hepatocellular carcinoma. PMID: 27938492
    7. Nuclear HDAC2 immunopositivity was significantly higher in actinic cheilitis (AC) when compared with lip squamous cell carcinoma (LSCC). HDAC1 and HAT1 nuclear immunostaining were higher in AC, with no statistical significance. When comparing data with our previous study, we found a positive correlation between HDAC1 X DNMT1/DNMT3b, HDAC2 X DNMT3b, and HAT1 X DNMT1/DNMT3b for certain studied groups. PMID: 28107582
    8. AMPK phosphorylates DNMT1, RBBP7, and HAT1 and increases interactions of DNMT1, RBBP7, and HAT1. PMID: 28143904
    9. Results show a novel interaction of the Lsm4 RGG domain with HAT1 and RBBP7, leading to the possibility of a posttranslational modifications network involved in mRNP regulation. PMID: 27247266
    10. These data indicated that miR-486 aggravate the cholesterol accumulation in THP-1 cells by targeting HAT1. PMID: 26654953
    11. The expression of HAT1 was higher in the primary Esophageal carcinoma tumors and adjacent tissue as compared to that of the normal esophageal tissue and HAT1 expression was directly correlated with the poor tumor differentiation PMID: 25120766
    12. Data indicate that HAT1 is required for homologous recombination in DNA repair. PMID: 23653357
    13. the role of Hat1 in DNA damage repair is evolutionarily conserved, the ability of H3 acetylation to compensate for Hat1 deletion appears to be more variable PMID: 17052979
    14. HAT gene expression is required for cisplatin resistance and Clock and Tip60 regulate not only transcription, but also DNA repair, through periodic histone acetylation PMID: 18458078

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform A]: Nucleus matrix. Mitochondrion.; [Isoform B]: Cytoplasm. Nucleus. Nucleus matrix. Nucleus, nucleoplasm.
  • 蛋白家族:
    HAT1 family
  • 數據庫鏈接:

    HGNC: 4821

    OMIM: 603053

    KEGG: hsa:8520

    STRING: 9606.ENSP00000264108

    UniGene: Hs.632532



主站蜘蛛池模板: 久在线精品视频线观看| a亚洲va欧美va国产综合| 亚洲精品久久久中文字幕痴女| 国产av仑乱内谢| 日韩人妻熟女中文字幕aⅴ春菜| 亚洲高清专区日韩精品| 国产成人av在线影院无毒| 暴力调教一区二区三区| 国产精品无码一区二区三区电影| 波多野结衣的av一区二区三区 | 九九久久精品国产免费看小说| 久久人妻精品白浆国产| 国产精品免费久久久久影院| 日产幕无线码三区在线| 女学生14毛片视频片二毛| 久久精品亚洲中文字幕无码麻豆| а√在线中文网新版地址在线| 国产午夜成人av在线播放| 久久无码中文字幕无码| 欧美人与动性xxxxbbbb | 成·人免费午夜无码视频蜜芽| 亚洲欧美不卡高清在线| 插我一区二区在线观看| 欧美大浪妇猛交饥渴大叫| 无遮挡十八禁污污网站免费| 无码人妻久久1区2区3区| 欧美最新精品videossexohd| 亚洲欧洲自拍拍偷午夜色| 国产好爽…又高潮了毛片| 国产69精品久久久久乱码| 正在播放国产乱子伦最新视频| 8x8ⅹ在线永久免费入口| 人人鲁人人莫人人爱精品| 亚洲精品无码久久久久av老牛| 国内揄拍国内精品少妇| 苍井空张开腿实干12次| 国产午费午夜福利200集| 一区二区三区毛aaaa片特级| 国产伦孑沙发午休精品| 毛片tv网站无套内射tv网站| 成人综合网亚洲伊人|