在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HARS Antibody

  • 中文名稱:
    HARS兔多克隆抗體
  • 貨號:
    CSB-PA002910
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of COLO205 cells using HisRS Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    HARS
  • 別名:
    cytoplasmic antibody; EC 6.1.1.21 antibody; FLJ20491 antibody; HARS antibody; HisRS antibody; Histidine tRNA ligase, cytoplasmic antibody; histidine translase antibody; Histidine tRNA ligase antibody; Histidine--tRNA ligase antibody; Histidyl tRNA synthetase antibody; Histidyl-tRNA synthetase antibody; HRS antibody; Human histidyl tRNA synthetase homolog (HO3) mRNA complete cds antibody; SYHC_HUMAN antibody; USH3B antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human HisRS.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance.
  • 基因功能參考文獻:
    1. This study suggests that the human HisRS genes, while descending from a common ancestor with dual function for both types of tRNA(His), have acquired highly specialized tRNA recognition properties through evolution. PMID: 28321488
    2. Despite the similar kinetics, differential scanning fluorimetry revealed that Y454S is less thermally stable than Wild Type HARS, and cells from Y454S patients grown at elevated temperatures demonstrate diminished levels of protein synthesis compared to those of Wild Type cells. The thermal sensitivity associated with the Y454S mutation represents a biochemical basis for understanding Usher Syndrome Type IIIB. PMID: 28632987
    3. Loss of function mutations in histidyl-tRNA synthetase cause a spectrum of inherited peripheral neuropathies PMID: 26072516
    4. Data suggest that by comparing human and trypanosomatid histidyl-tRNA synthetases (HisRS) may provide opportunities for developing specific inhibitors of Trypanosoma brucei HisRS. PMID: 25151410
    5. Secreted histidyl-tRNA synthetase splice variants elaborate major epitopes for autoantibodies in inflammatory myositis. PMID: 24898250
    6. Data indicate that higher anti-Jo1 levels were associated with disease severity in antisynthetase syndrome (ASS) patients. PMID: 24286268
    7. Non-Jo-1 anti-synAb positive patients have decreased survival compared with Jo-1 patients. PMID: 23422076
    8. Findings suggest that histidyl-tRNA synthetase (HARS) is associated with axonal peripheral neuropathy. PMID: 22930593
    9. The crystal structure of a novel splice variant of a tRNA synthetase lacking the entire catalytic domain. PMID: 22958643
    10. Although anti-Jo1 positive patients with antisynthetase syndrome share features of patients with anti-PL7/PL12 antibody, they exhibit many differences regarding clinical phenotype and long-term outcome. PMID: 22326685
    11. Study identified sequence variants in the known disease-causing genes SLC6A3 and FLVCR1, and present evidence to strongly support the pathogenicity of variants identified in TUBGCP6, BRAT1, SNIP1, CRADD, and HARS. PMID: 22279524
    12. genomic organization of the HARS locus and mapping of transcripts originating from a bi-directional promoter controlling the differential expression of these gene PMID: 12056811
    13. Demonstrating histidyl-tRNA synthetase (Jo-1)-specific T cell responses represents a key step in establishing the hypothesis that Jo-1 drives T cell-mediated autoimmunity in Jo-1+ polymyositis. PMID: 12471150
    14. the TSG101 interaction with HRS is a crucial step in endocytic down-regulation of mitogenic signaling and this interaction may have a role in linking the functions of early and late endosomes PMID: 12802020
    15. A proteolytically sensitive conformation of HisRS exists in the lung, the target tissue associated with this autoantibody response. PMID: 17665459
    16. clinical and prognostic profiles of 45 patients displaying anti-histidyl-tRNA synthetase autoantibodies were determined PMID: 17785330

    顯示更多

    收起更多

  • 相關疾病:
    Usher syndrome 3B (USH3B); Charcot-Marie-Tooth disease 2W (CMT2W)
  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Class-II aminoacyl-tRNA synthetase family
  • 組織特異性:
    Brain, heart, liver and kidney.
  • 數據庫鏈接:

    HGNC: 4816

    OMIM: 142810

    KEGG: hsa:3035

    STRING: 9606.ENSP00000425634

    UniGene: Hs.528050



主站蜘蛛池模板: 欧美大屁股xxxx高跟欧美黑人| 亚洲精品国产成人| 黑人巨茎美女高潮视频| 亚洲国产精品久久网午夜| 最新国产aⅴ精品无码| 国产拍揄自揄免费观看| 免费特级黄毛片| 久久国产精品免费一区二区三区| 国产片精品av在线观看夜色| 小草国产精品情侣| 天堂在线中文| 天干天干天啪啪夜爽爽99| 婷婷俺也去俺也去官网| 亚洲熟妇av一区| 可以直接免费观看的av网站| 一本一道av无码中文字幕| 在线看片免费人成视频影院看| 成人精品v视频在线| 青青草97国产精品免费观看| 久久九九久精品国产| 亚洲免费福利在线视频| 婷婷射精av这里只有精品| 美女露全乳无遮掩视频| 亚洲暴爽av天天爽日日碰| 美女裸免费观看网站| 夜夜躁狠狠躁日日躁| 伊人久久综合成人网| 在线人成免费视频69国产| 欧美乱大交xxxxx疯狂俱乐部| 亚洲中文字幕无码一区二区三区| 一区二区三区四区在线 | 中国| 在线播放免费播放av片| 亚洲欧洲精品成人久久曰| 狠狠色噜噜狠狠狠狠av不卡| 亚洲va久久久噜噜噜久久无码| 午夜成人理论无码电影在线播放| 欧美一区二区日韩国产 | 成人午夜福利院在线观看| 无码高潮少妇毛多水多水| 亚欧美无遮挡hd高清在线视频| 欧美video性欧美熟妇|