在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Gzma Antibody

  • 中文名稱:
    Gzma兔多克隆抗體
  • 貨號:
    CSB-PA010081LA01MO
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: Raji whole cell lysate, Jurkat whole cell lysate, K562 whole cell lysate
      All lanes: Gzma antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 29 kDa
      Observed band size: 29 kDa
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Mus musculus (Mouse) Gzma Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    Gzma
  • 別名:
    Gzma antibody; Ctla-3 antibody; Ctla3 antibody; Mtsp-1 antibody; Granzyme A antibody; EC 3.4.21.78 antibody; Autocrine thymic lymphoma granzyme-like serine protease antibody; CTLA-3 antibody; Fragmentin-1 antibody; T cell-specific serine protease 1 antibody; TSP-1 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Mouse, Human
  • 免疫原:
    Recombinant Mouse Granzyme A protein (29-260AA)
  • 免疫原種屬:
    Mus musculus (Mouse)
  • 標記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,Gzma Antibody (CSB-PA010081LA01MO),的標記方式是Non-conjugated。對于Gzma Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA010081LB01MO Gzma Antibody, HRP conjugated ELISA
    FITC CSB-PA010081LC01MO Gzma Antibody, FITC conjugated
    Biotin CSB-PA010081LD01MO Gzma Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.
  • 基因功能參考文獻:
    1. GzmA and gzmB were predominantly expressed by natural killer cells, and during abdominal sepsis, the percentage of these cells expressing gzms in peritoneal lavage fluid decreased, while the amount of expression in the gzm(+) cells increased PMID: 28694562
    2. a novel endogenous trigger for autoimmune diabetes and an in vivo role for granzyme A in maintaining immune tolerance. PMID: 28733313
    3. this study shows that gzmA and gzmB partly regulate local inflammation during early pneumonia but eventually play an insignificant role during pneumosepsis by the common human pathogen Klebsiella pneumoniae PMID: 26894590
    4. Granzyme A does not have a crucial role in vivo in the protective response to tuberculosis. PMID: 27055232
    5. Data indicate N-terminomics on the human and mouse granzymes A and K by combined fractional diagonal chromatography (COFRADIC). PMID: 25383893
    6. The results, in susceptible B6 mice for GzmB and in resistant 129/Sv mice for GzmA and/or the GzmB cluster, point to granzyme-mediated host defense regulation in the liver in experimental visceral leishmaniasis. PMID: 25452549
    7. Estrogen increases the extracellular expression and interleukin (IL)-12-induced activity of a critical member of serine protease family granzyme A. PMID: 24840346
    8. functional divergence between human and mouse granzyme A PMID: 24505135
    9. We have demonstrated that cell death can be induced when mGzmA is delivered by primary natural killer cells via authentic Cytotoxic lymphocyte/target cell interactions. PMID: 23744295
    10. Regulated secretion of granzyme A and cytotoxic killing was enhanced and correlated with increased vesicle-associated membrane protein 7 availability. PMID: 23084031
    11. GzmA deficiency in filarial infection is linked with reduced inflammation and a trend toward increased alternatively activated macrophages. PMID: 21248253
    12. granzyme A- and B-cluster deficiency delays the acute progression of pneumovirus disease by reducing alveolar injury. PMID: 20018616
    13. the genes for perforin, the three major T cell granzymes (A-C) and IFN-gamma are differentially expressed during primary activation of naive CD8(+) T cells, kinetically and at the single-cell level PMID: 12039912
    14. granzyme A and granzyme B have a similar potential to induce rapid perf-mediated apoptosis but that their individual contribution to the underlying intracellular process is dictated by the quality of the target cell PMID: 12115618
    15. NK cell mediated tumor control is dependent on granzymes. PMID: 12355441
    16. some cytolytic T lymphocytes mature into perforin/granzyme-expressing effector cells in the mediastinal lymph node and are detectable when they accumulate in lung infection PMID: 12601154
    17. In all tumor models examined thus far, granzyme A is not necessary for tumor rejection mediated by the perforin pathway in vivo. PMID: 12847210
    18. gzmA and gzmB induce multiple independent cell death pathways; all gzm-induced apoptotic features analyzed depend critically on perf. PMID: 15534000
    19. polymorphonuclear leukocytes from mice and humans lack the 3 cytotoxic effector molecules, gzmA, granzyme B, and perforin, generally associated with natural killer and cytotoxic T lymphocytes PMID: 15998831
    20. IL-2 increased the expression of perforin and granzyme A, B, and C mRNA; induction of granzyme A, B, and C mRNA required exogenous IL-2, whereas induction of perforin and IFN-gamma expression did not. PMID: 16339537
    21. CTLs from granzyme AB(-/-) mice induce target cell death by a unique mechanism that is distinct from both perforin lysis and apoptosis. PMID: 16606695
    22. Mouse granzyme B is 30 times less cytotoxic than human granzyme B and does not require Bid for killing but regains cytotoxicity on engineering of its active site cleft. Mouse granzyme A is considerably more cytotoxic than human granzyme A. PMID: 17116752
    23. Skin-, but not lung-associated primary mast cells as well as in vitro-differentiated bone marrow-derived mast cells (BMMC) express granzyme (gzm) B, but not gzmA or perforin (perf). PMID: 17599099
    24. GzmA accesses the mitochondrial matrix to cleave the complex I protein NDUFS3, an iron-sulfur subunit of the NADH:ubiquinone oxidoreductase complex I. PMID: 18485875
    25. grzK plays an important role in CD8(+) T-cell cytotoxicity both in the presence and absence of grzA and B. PMID: 18788942
    26. the granule secretory pathway plays an unexpected role in inflammation, with GzmA acting as an endogenous modulator. PMID: 18951048
    27. Neither gzmA nor gzmB is required for rapid and efficient in vivo cytotoxicity by cytotoxic T (Tc) cells. PMID: 19525394

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted. Cytoplasmic granule.
  • 蛋白家族:
    Peptidase S1 family, Granzyme subfamily
  • 組織特異性:
    Found in cytotoxic lymphocytes and in normal lymphoid tissues such as thymus and spleen.; [Isoform HF1]: More abundant in lymphoid tissues than isoform HF2.
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 一个人看的日本hd免费| 99精品久久99久久久久| 黄瓜视频在线观看| 最新国产精品拍自在线观看| 国产熟女精品视频大全| 人妻avav中文系列久久| 成人av片在线观看免费| 久久经精品久久精品免费观看 | 99re8精品视频热线观看| 色五月丁香五月综合五月| 国产国拍精品av在线观看按摩 | 狠狠躁夜夜躁人人爽天天| 蜜色欲多人av久久无码| 免费无码成人av在线播放不卡| 国产精品天天狠天天看| 狠狠综合久久av一区二区| 香蕉人妻av久久久久天天| 看成年全黄大色黄大片| 97色伦午夜国产亚洲精品| 亚洲综合色区中文字幕| 蜜桃网站入口在线进入| 区二区三区玖玖玖| 狠狠色噜噜狠狠狠8888在| 成人三级视频在线观看一区二区| 亚洲一区二区三区四区五区六区| 女性女同性aⅴ免费观女性恋| 久久96国产精品久久久| 特黄做受又粗又长又大又硬| 国产成人年无码av片在线观看| 亚洲精品一区二区三区中文字幕 | av在线观看地址| 四虎永久在线精品免费视频观看| 久久66热人妻偷产精品| 中国女人内谢69xxxx免费视频| 国产乱子夫妻xx黑人xyx真爽| 国产寡妇偷人在线观看| 国产一区精选播放022| 国产精品毛片大码女人| 人禽无码视频在线观看 | 香蕉人妻av久久久久天天| 日本欧美一区二区三区高清 |