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  4. Gp2 Antibody, Biotin conjugated

Gp2 Antibody, Biotin conjugated

  • 中文名稱：
    Gp2兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA880511LD01MO
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Mus musculus (Mouse) Gp2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Gp2 antibody; Pancreatic secretory granule membrane major glycoprotein GP2 antibody; Pancreatic zymogen granule membrane protein GP-2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Mouse
  • 免疫原：
    Recombinant Mouse Pancreatic secretory granule membrane major glycoprotein GP2 protein (22-531AA)
  • 免疫原種屬：
    Mus musculus (Mouse)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Functions as an intestinal M-cells transcytotic receptor specific of type-I-piliated bacteria that participate in the mucosal immune response toward these bacteria. At the apical membrane of M-cells binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to ellicit a mucosal immune response.
  • 基因功能參考文獻：
    1. GP2 is a popular secretory product released from mucous glands and secretory cells and may support defense mechanisms against pathogenic bacteria in the tubular organs open to the external milieu. PMID: 28003582
    2. GP2-expressing cells in paranasal sinuses are in the lineage of goblet cells. PMID: 25355440
    3. Tightly linked to homologue THP. A Gp2 knockout mouse was established which does express THP. PMID: 15325280
    4. unlikely that GP2 serves a major intracellular role within the acinar cell, may be active after it is secreted PMID: 15385539
    5. glycoprotein 2 (GP2), specifically expressed on the apical plasma membrane of M cells among enterocytes, serves as a transcytotic receptor for mucosal antigens PMID: 19907495

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  • 亞細胞定位：
    Zymogen granule membrane; Lipid-anchor, GPI-anchor. Secreted. Cell membrane; Lipid-anchor, GPI-anchor. Apical cell membrane; Lipid-anchor, GPI-anchor. Membrane raft; Lipid-anchor, GPI-anchor. Endosome.
  • 組織特異性：
    Specifically expressed by M (microfold) cells which are atypical epithelial cells of the intestine.
  • 數據庫鏈接：


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