在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GZMM Antibody, FITC conjugated

  • 中文名稱:
    GZMM兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA010085LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) GZMM Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    GZMM
  • 別名:
    GRAM_HUMAN antibody; Granzyme M (lymphocyte met ase 1) antibody; Granzyme M antibody; GranzymeM antibody; GZM M antibody; Gzmm antibody; HU Met 1 antibody; HU-Met-1 antibody; LMET 1 antibody; LMET1 antibody; Lymphocyte met ase 1 antibody; MET 1 antibody; Met 1 serine protease antibody; Met ase antibody; Met-1 serine protease antibody; Met-ase antibody; MET1 antibody; Met1 serine protease antibody; Natural killer cell granular protease antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Granzyme M protein (98-243AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.
  • 基因功能參考文獻:
    1. GzMM has a critical role during early stages of inflammation in ulcerative colitis; in its absence colonic inflammation is enhanced. PMID: 27441655
    2. We also report that TNFalpha induces the attachment of Met1-linked Ub chains directly to TNF receptor 1, which do not seem to be attached covalently to Lys63-linked or other types of ubiquitin chain. PMID: 27133719
    3. Granzym M may be important in regulating HCMV latency and reactivation in SCT patients. PMID: 24316590
    4. GrM is expressed in HCMV-specific CD8thorn T cells and cleaves host cell protein hnRNP K in the presence of RNA. PMID: 23099853
    5. FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade. PMID: 21979465
    6. Results indicate that cellular overexpression of SERPINB4 inhibits recombinant GrM-induced as well as NK cell-mediated cell death. PMID: 21857942
    7. Results describe the structural characterization of granzyme M by molecular modeling as well as by detailed comparison with other granzymes. PMID: 20107908
    8. Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71. PMID: 21059895
    9. survivin cleavage by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells PMID: 20406824
    10. These findings support not only a role for GrM in the innate but also in the adaptive immune response. PMID: 19896187
    11. GM expression is a distinctive feature of the nasal NK/T-cell, gamma delta T-cell, and intestinal T-cell lymphomas, and suggest that these tumors develop from lymphocytes involved in innate immunity. PMID: 12506019
    12. granzyme M represents a third major and specialized perforin-dependent cell death pathway that plays a significant role in death mediated by NK cells PMID: 15028722
    13. Granzyme (Gzm)M can directly degrade inhibitor of caspase-activated DNase (ICAD) to activate CAD, leading to DNA damage; GzmM cleaves DNA damage sensor enzyme poly(ADP-ribose) polymerase to prevent cellular DNA repair and force apoptosis. PMID: 16818775
    14. Granzyme M targets major components of the cytoskeleton that likely contribute to natural killer (NK) cell-induced cell death. PMID: 18523284
    15. NPM is essential for cell viability, these data suggest that targeting of NPM by granzyme M may contribute to tumor cell eradication by abolishing NPM function. PMID: 19103589
    16. Structure-based mutagenesis reveals that the amino-terminus and catalytic triad of GzmM are most essential for proteolytic function. PMID: 19542453

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted. Cytoplasmic granule. Note=Granules of large granular lymphocytes.
  • 蛋白家族:
    Peptidase S1 family, Granzyme subfamily
  • 組織特異性:
    Highly and constitutively expressed in activated natural killer (NK) cells.
  • 數據庫鏈接:

    HGNC: 4712

    OMIM: 600311

    KEGG: hsa:3004

    STRING: 9606.ENSP00000264553

    UniGene: Hs.465511



主站蜘蛛池模板: 拍真实国产伦偷精品| 国产av久久久久精东av| 日本免费一本一二区三区| 人人妻人人澡人人爽精品欧美| 免费的黄网站在线观看| 国产精品久久久久久久久软件| 欧美亚洲日韩国产综合电影| 亚洲精品久久66国产高清| 熟妇人妻无乱码中文字幕| 狠狠综合久久av一区二区| 亚洲日韩精品一区二区三区无码| 久久婷婷五月综合中文字幕 | 日本亚洲vr欧美不卡高清专区| 九九久久精品国产波多野结衣| 真实的国产乱xxxx| 成人免费视频一区二区| 免费h动漫无码网站| 国产精品人妻熟女男人的天堂| 免费人成自慰网站| 亚洲天堂2017无码中文| 一本一道久久综合久久| 人妻av无码专区| √最新版天堂资源网在线| 中文字幕乱码人在线视频1区| 东京热大乱系列无码| 亚洲精品一区二区三区四区乱码 | 欧美又粗又大又硬又长又爽视频 | 无码日韩人妻av一区免费| 亚洲男同gv在线观看| 两个人看的www在线观看| 中文字幕v亚洲日本在线| 国产精品亚洲一区二区z| 无码人妻精品一区二区三区9厂| 正在播放重口老熟女露脸| 久久久久久无码精品人妻a片软件| 成人毛片18女人毛片免费| 欧美在线看片a免费观看| 亚洲 日韩 欧美 成人 在线| 亚洲中文字幕无码久久2018| 成人h视频在线观看| 亚洲欧美偷国产日韩|