在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GZMH Antibody

GZMH Antibody

  • 中文名稱：
    GZMH兔多克隆抗體
  • 貨號：
    CSB-PA966723
  • 規格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from K562 cells, using GRAH antibody.
    • Immunofluorescence analysis of A549 cells, using GRAH antibody.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) GZMH Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GZMH
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human GRAH.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IF 1:100-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.
  • 基因功能參考文獻：
    1. Granzyme H did directly process DFF45, potentially leading to DNA damage. PMID: 23352961
    2. Upon reactive center loop cleavage at Phe-343,SERPINB1 covalently complexes with GzmH. SERPINB1 overexpression suppresses GzmH- or LAK cell-mediated cytotoxicity. Crystal structures show possible conformational changes in GzmH for the suicide inhibition. PMID: 23269243
    3. An unusual RKR motif (Arg39-Lys40-Arg41), conserved only in GzmH, helps define the S3' and S4' binding regions, indicating the preference for acidic residues at the P3' and P4' sites. PMID: 22156497
    4. GzmH suppresses viral replication through association with the hepatitis B virus x protein. PMID: 22156339
    5. Granzyme C rapidly induces target cell death by attacking nuclear and mitochondrial targets and that these targets are distinct from those used by granzyme B to cause classical apoptosis. PMID: 12515723
    6. granzyme H complements the pro-apoptotic function of granzyme B in human NK cells PMID: 15069086
    7. Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition. PMID: 17363894
    8. Expression levels of GzmH in naive natural killer cells and its killing ability support the role of the protease in triggering an alternative cell-death pathway in innate immunity. PMID: 17409270
    9. GzmH may play an essential role in caspase-dependent pathogen clearance in the innate immunity that may complement the proapoptotic function of GzmB in human NK cells. PMID: 17765974
    10. Granzyme H could have evolved a proteolytic specificity that both interferes directly with adenovirus replication and prevents the virus from blocking the potent pro-apoptotic activity of granzyme B. PMID: 17766182
    11. Cleavage of La protein by granzyme H generates a COOH-terminal truncated form of La protein that loses nuclear localization and decreases hepatitis C virus-internal ribosome entry site-mediated translational activity. PMID: 19039329

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytolytic granule.
  • 蛋白家族：
    Peptidase S1 family, Granzyme subfamily
  • 組織特異性：
    Constitutively expressed in NK cells.
  • 數據庫鏈接：

    HGNC: 4710

    OMIM: 116831

    KEGG: hsa:2999

    STRING: 9606.ENSP00000216338

    UniGene: Hs.348264



主站蜘蛛池模板： 粗大的内捧猛烈进出视频| 精品影片在线观看的网站| 精品久久久久成人码免费动漫| 亚欧成a人无码精品va片| 1区2区3区高清视频| 亚洲аv电影天堂网| 无套内射chinesehd熟女| 狠日狠干日日射| 亚洲国产精品久久久久久无码| 欧美人与动牲交a欧美精品| 人与禽交av在线播放| 久久香综合精品久久伊人| 久久99国产精品二区| 久久久久亚洲精品成人网| 无码aⅴ精品一区二区三区| 天天爽天天爽夜夜爽毛片| 欧美成人免费全部观看国产| 少妇和邻居做不戴套视频| 亚洲成_人网站图片| 欧美成人猛片aaaaaaa| 国产爆乳无码视频在线观看3| 亚洲日本va午夜中文字幕久久| 欧美人与禽z0zo牲伦交| 久久久精品人妻一区二区三区四| 图片小说视频一区二区| 久久精品人妻一区二区三区| 中文成人无码精品久久久动漫 | 日韩精品一区二区三区| 成人免费的视频| 亚洲美女精品免费视频| 国内精品久久久久电影院| 中文字幕人妻熟女人妻| 国产性生交xxxxx免费| 欧洲熟妇色xxxxx视频 | 国产精品无码嫩草地址更新| 一本大道无码人妻精品专区| 亚洲熟女综合一区二区三区| 尤物国精品午夜福利视频| 国产精品自在拍一区二区不卡 | 国产午夜精品一区二区三区老| 亚洲中文无码mv|