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  4. GTF2H1 Antibody

GTF2H1 Antibody

  • 中文名稱(chēng)：
    GTF2H1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA009042
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Basic transcription factor 2 62 kDa subunit antibody; Basic transcription factor 62 kDa subunit antibody; BTF 2 antibody; BTF2 antibody; BTF2 p62 antibody; General transcription factor IIH polypeptide 1 antibody; General transcription factor IIH subunit 1 antibody; General transcription factor IIH, polypeptide 1, 62kDa antibody; gtf2h1 antibody; TF2H1 antibody; TF2H1_HUMAN antibody; TFB1 antibody; TFIIH antibody; TFIIH basal transcription factor complex p62 subunit antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human TFIIH p62.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
  • 基因功能參考文獻(xiàn)：
    1. Data suggest that a common TFIIH subunit p62 recruitment mechanism is shared by UV-stimulated scaffold protein A (UVSSA) in transcription-coupled repair (TCR) and xeroderma pigmentosum, complementation group C protein (XPC) in global genome repair (GGR). PMID: 29069470
    2. Here, the authors show that an acidic region of DP1, whose function has remained elusive, binds to the plekstrin homology (PH) domain of the p62 subunit of TFIIH that contributes to transcriptional activation. PMID: 27825926
    3. Virulence factor NSs of rift valley fever virus recruits the FBXO3 to degrade subunit p62 of general transcription factor TFIIH. PMID: 24403578
    4. These data suggest that the RVFV NSs protein is able to interact with the TFIIH subunit p62 inside infected cells and promotes its degradation, which can occur directly in the nucleus. PMID: 21543505
    5. cdk1 phosphorylates p62 in vitro and in vivo at T269 and S272, which is necessary for the maintenance of appropriate cyclin B1 levels and the levels of cdk1 activity necessary to allow cells to properly enter and exit mitosis. PMID: 20974803
    6. transcription factor b3, previously identified as a component of the transcription factor IIH core complex, is shown instead to be transcription factor b4 PMID: 14500720
    7. p62 subunit of TFIIH interacts with TRbeta in a ligand-dependent manner. PMID: 15625236
    8. The pleckstrin homology domain from the 62 kDa subunit Tfb1 (residues 1-108) of TFIIH is sufficient for binding to the activation domain of herpes simplex virus protein VP16. PMID: 15909982
    9. GTF2H1 polymorphisms/haplotypes may contribute to genetic susceptibility to lung cancer. PMID: 18692935

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    TFB1 family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 4655

    OMIM: 189972

    KEGG: hsa:2965

    STRING: 9606.ENSP00000265963

    UniGene: Hs.577202



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