在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GSPT1 Antibody

  • 中文名稱:
    GSPT1兔多克隆抗體
  • 貨號:
    CSB-PA009966GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    GSPT1
  • 別名:
    GSPT1 antibody; ERF3AEukaryotic peptide chain release factor GTP-binding subunit ERF3A antibody; Eukaryotic peptide chain release factor subunit 3a antibody; eRF3a antibody; G1 to S phase transition protein 1 homolog antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human GSPT1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ETF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes.
  • 基因功能參考文獻(xiàn):
    1. PABP enhances the productive binding of the eRF1-eRF3 complex to the ribosome, via interactions with the N-terminal domain of eRF3a which itself has an active role in translation termination. PMID: 27418677
    2. Data found that the N-terminal glycine repeat of eRF3a influences eRF3a-PABP interaction and that eRF3a 12-GGC allele has a decreased binding affinity for PABP. PMID: 26818177
    3. GAB2, GSPT1, TFDP2 and ZFPM1 are four new susceptibility loci for testicular germ cell tumor. PMID: 26503584
    4. The survivin and eRF3 complex may function in spindle formation and segregation of chromosomes and cytokinesis. PMID: 23377885
    5. Overexpression of ID1 in two different cell lines induced STMN3 and GSPT1 at the transcriptional level, while depletion of ID1 reduced their expression. PMID: 25028095
    6. The proteolytic cleavage of eRF3a and eRF3b into p-eRF3 leads to release an amino-terminal fragment containing nuclear export signal to allow the relocalization of eRF3 into the nucleus to interact with the p14ARF. PMID: 24569073
    7. ERF3 is targeted for caspase-mediated proteolytic cleavage and degradation during DNA damage-induced apoptosis. PMID: 23054082
    8. Our results show that the presence of the longer allele of eRF3a is correlated with threefold increased risk of breast cancer development PMID: 22101789
    9. A biological role for the overlapping ERF3 PAM2 motifs in the regulation of deadenylase accessibility to PABPC1 at the 3' end of poly(A). PMID: 23019593
    10. crystal structures of the MLLE domain from PABPC1 in complex with the two PAM2 regions of eRF3 PMID: 20418951
    11. GSPT1/eRF3 is proteolytically processed into an IAP-binding protein PMID: 12865429
    12. Human translation termination factor eRF3/GSPT1 is an interacting partner of RNase L. PMID: 15908960
    13. Polyglycine expansions in eukaryotic translation release factor 3 are associated with gastric cancer susceptibility PMID: 15987717
    14. eRF3a controls the formation of the termination complex by modulating eRF1 protein stability. PMID: 15987998
    15. Further, we describe a novel complex that contains the NMD factors SMG-1 and Upf1, and the translation termination release factors eRF1 and eRF3 (SURF). an association between SURF and the EJC is required for SMG-1-mediated Upf1 phosphorylation and NMD. PMID: 16452507
    16. GSTP1 inhibits the binding of MAP kinase kinase kinase 5 (MAP3K5) to the 14-3-3 protein, a MAP3K5 inhibitor, while a novel role of GSPT1 is revealed in the regulation of apoptosis signal-regulating kinase 1 (ASK1)-mediated apoptosis. PMID: 17700517
    17. eRF3a is degraded by the proteasome when not associated with eRF1; proteasomal degradation of eRF3a controls translation termination complex formation by adjusting the eRF3a level to that of eRF1. PMID: 18083835
    18. eRF3a/GSPT1 12-GGC allele increases the susceptibility for breast cancer development. PMID: 19424636
    19. GSPT1 GGC(12) allele was present in 2.2% of colorectal cancer patients but was absent in Crohn disease patients and in the control group PMID: 19963113

    顯示更多

    收起更多

  • 蛋白家族:
    TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, ERF3 subfamily
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4621

    OMIM: 139259

    KEGG: hsa:2935

    STRING: 9606.ENSP00000398131

    UniGene: Hs.528780



主站蜘蛛池模板: 欧美成人精品三级一二三在线观看 | 区二区三区玖玖玖| 欧美综合自拍亚洲综合区| 国语精品自产拍在线观看网站| 成人无码视频| 98国产精品综合一区二区三区| 超碰cao已满18进入离开官网| 成人免费大片黄在线观看com| 国产三级在线观看完整版| 久久发布国产伦子伦精品| 2020年最新国产精品正在播放| 亚洲国产日韩欧美综合a| 亚洲欧美国产精品久久| 男人用嘴添女人私密视频| 18禁男女污污污午夜网站免费暖暖| 人妻无码中文专区久久五月婷| 热re99久久精品国99热| 成人亚洲a片v一区二区三区日本 | 中文字幕三级人妻无码视频 | 日本中文字幕一区二区有码在线 | 国产交换配乱婬视频偷网站| 97爱亚洲综合成人| 国产97色在线 | 日韩| 无码写真精品永久福利在线| 无码人妻精品一区二区三区下载| 无码人妻一区二区三区免费看成人| 放荡的美妇在线播放| 中文字幕乱码亚洲无线码三区| 国色天香社区视频| 欧美黑人添添高潮a片www| 亚洲日产av中文字幕无码偷拍| 偷拍农村老熟妇xxxxx7视频| 国产成人久久精品二区三区| 一本一道精品欧美中文字幕| 国产成人av一区二区三区无码| 国产高清自产拍av在线| 色一情一乱一伦一视频免费看| 亚洲欧洲无码av不卡在线| 亚洲旡码欧美大片| 久久久久无码精品亚洲日韩| 久久中文字幕无码a片不卡古代|