在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GSDMA Antibody, FITC conjugated

GSDMA Antibody, FITC conjugated

  • 中文名稱：
    GSDMA兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA850415LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) GSDMA Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    GSDMA antibody; GSDM antibody; GSDM1 antibody; FKSG9Gasdermin-A antibody; Gasdermin-1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Gasdermin-A protein (64-172AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-A, N-terminal) binds to membranes and forms pores, triggering cell death.; Pore-forming protein that causes membrane permeabilization and pyroptosis. Released upon cleavage in vitro of genetically engineered GSDMA, and binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis. Binds to membrane inner leaflet lipids, such as phosphatidylinositol (4,5)-bisphosphate. The functional mechanisms and physiological proteases that cleave and activate this pore-forming protein are unknown.
  • 基因功能參考文獻(xiàn)：
    1. modest changes (8-13%) in promoter methylation levels of ZPBP2 and GSDMA may cause substantial changes in RNA levels and allelic expression of ZPBP2 and ORMDL3 is mediated by DNA methylation PMID: 28241063
    2. GSDMA was identified as a susceptibility gene for systemic sclerosis. PMID: 28314753
    3. we investigated the association between GSDMA and GSDMB variants and the incidence of adult and childhood asthma among Jordanians.An association between the GSDMB T/C single nucleotide polymorphism (SNP) genotype and the incidence of childhood asthma was found PMID: 26886240
    4. The local genotype influences methylation levels at SLC22A5 and ZPBP2 promoters independently of the asthma status. Further studies are necessary to confirm the relationship between GSDMA-ZPBP2 and SLC22A5 methylation and asthma in females and males separately. PMID: 26671913
    5. Based on our results and published findings on GSDMA, GSDMB, LRRC3C, and related proteins, we propose that this locus in part affects IBD susceptibility via effects on apoptosis and cell proliferation PMID: 26484354
    6. Study identified significantly white blood cell count (WBC) level associated SNPs of three separate genes GSDMA, MED24, and PSMD3 in European continent (EA) subjects. PMID: 22037903
    7. The GSDMA (rs7212938) and GSDMB (rs7216389) polymorphisms are associated with asthma susceptibility and intermediate asthma phenotypes. PMID: 21337730
    8. Results suggest an association of 17q21 polymorphisms with ORMDL3, GSDMA expression, and IL-17 secretion early in life. These observations may imply a functional role of the 17q21 locus affecting T-cell development during immune maturation. PMID: 21546069
    9. The present data suggest that TGF-beta, LMO1, possibly RUNX3, and GSDM form a regulatory pathway for directing the pit cells to apoptosis. PMID: 17471240
    10. Study investigated the expression pattern of the GSDM family genes in the upper gastrointestinal epithelium and cancers. PMID: 19051310
    11. Evolutionary recombination hotspot around the GSDML-GSDM locus is closely linked to oncogenomic recombination hotspot around the PPP1R1B-STARD3-TCAP-PNMT-PERLD1-ERBB2-C17orf37-GRB7 amplicon at human chromosome 17q12. PMID: 15010812

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    [Gasdermin-A]: Cytoplasm, perinuclear region. Cytoplasm, cytosol.; [Gasdermin-A, N-terminal]: Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Gasdermin family
  • 組織特異性：
    Expressed predominantly in the gastrointestinal tract and, at a lower level, in the skin. Also detected in mammary gland. In the gastrointestinal tract, mainly expressed in differentiated cells, including the differentiated cell layer of esophagus and muc
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 13311

    OMIM: 611218

    KEGG: hsa:284110

    STRING: 9606.ENSP00000301659

    UniGene: Hs.448873



主站蜘蛛池模板： 国产av久久久久精东av| 人妻无码手机在线中文| 日本韩国亚洲欧美在线| 亚洲a∨无码国产精品久久网| 2021无码天堂在线| 精品一卡2卡三卡4卡免费网站| 亚洲精品www久久久| 国产午夜精品一区理论片飘花 | 久久久精品久久久久久96| 亚洲熟妇av午夜无码不卡| 色悠久久久久综合先锋影音下载| 久久久橹橹橹久久久久| 男人的天堂在线视频| 国产在视频线精品视频| 久久精品国产曰本波多野结衣 | 亚洲欧美日韩精品色xxx| 国产精品沙发系列| 午夜视频在线在免费| 尤物tv国产精品看片在线| 国产女女做受ⅹxx高潮| 狠狠色狠狠色综合| 色94色欧美sute亚洲线路二 | 人妻无码一区二区三区tv | 欧美一区二区三区久久综合| 影音先锋人妻av中文字幕久久| 国产suv精二区| 97久久精品人人槡人妻人| 国产免费无码一区二区三区| 蜜臀av色欲a片无码精品一区| 亚洲 丝袜 制服 欧美 另类| 免费女人18毛片a毛片视频| 最近中文av字幕在线中文| 亚洲爆乳无码精品aaa片蜜桃| 伊人色综合久久天天五月婷| 偷欧洲亚洲另类图片av天堂| 日产精品99久久久久久| 欧美精品色婷婷五月综合| 亚洲熟妇国产熟妇肥婆| 亚洲性夜夜综合久久7777| 国产成年女人毛片80s网站| 欧美不卡一区二区三区|