在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GRID2 Antibody

  • 中文名稱:
    GRID2兔多克隆抗體
  • 貨號:
    CSB-PA269961
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from NIH/3T3 cells, using GRID2 antibody.
    • Immunofluorescence analysis of HuvEc cells, using GRID2 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) GRID2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    GRID2
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from internal of Human GRID2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IF 1:100-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex.
  • 基因功能參考文獻:
    1. Report on a consanguineous family with autosomal recessive childhood onset of cerebellar ataxia and delayed psychomotor development. Using whole exome sequencing we identified a novel homozygous missense variant [c.2128C > T, p.(Arg710Trp)] in GRID2 that segregates with the disease. The missense variant is located in a conserved region encoding the extracellular serine-binding domain of the GluD2 protein. PMID: 29207948
    2. GRID2 gene can be a suppressor in TNF-induced neurodegeneration which may help to understand the main factors leading to autism. PMID: 27019035
    3. Glutamate system genes including have been associated with disease risk in recent analyses from the Psychiatric Genomics Consortium. PMID: 26905411
    4. findings suggest a possible role of GRID2 in the susceptibility to develop mevalonate kinase deficiency. GRID2 gene associated with MKD: The rs1450500 SNP was differently distributed in patients with MKD with respect to those with recurrent fever. PMID: 25146332
    5. We demonstrated for the first time GRID2 expression and localization in human and murine retina, providing evidence for a novel functional role of GRID2 in the retina. PMID: 25122145
    6. GRID2 point mutations: cerebellar ataxia is the core phenotype, but with variable severity ranging from very mild adult-onset to congenital-onset linked to both the heterozygous and homozygous state of the variant, and the position of the mutation. PMID: 25841024
    7. GluD2 gating is triggered by type 1 metabotropic glutamate receptors. PMID: 24357660
    8. GRID2 mutations are associated with a recessive syndrome causing cerebellar ataxia and eye movement abnormalities. PMID: 24078737
    9. Tests for gene-environment interaction between these 33 genes and maternal smoking found evidence for interaction with two additional genes: GRID2 and ELAVL2 among European mothers PMID: 23512105
    10. Glutamate receptor delta2 is involved in a common mechanism that restricts the number of synaptic AMPA receptors at parallel fiber synapses in cerebellar Purkinje cells. PMID: 21368048
    11. Thus, phosphorylation of -2T and/or -1S of GluRdelta2 C-terminus by PKA may regulate the binding of GluRdelta2 to its scaffolding protein, Delphilin. PMID: 17027646
    12. The carboxy terminus of transgenic GluRdelta2 conveys the signal(s) necessary for long-term depression induction and motor learning. PMID: 18256267

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Spinocerebellar ataxia, autosomal recessive, 18 (SCAR18)
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Glutamate-gated ion channel (TC 1.A.10.1) family, GRID2 subfamily
  • 數據庫鏈接:

    HGNC: 4576

    OMIM: 602368

    KEGG: hsa:2895

    STRING: 9606.ENSP00000282020

    UniGene: Hs.162727



主站蜘蛛池模板: 被拉到野外强要好爽黑人| 成 人 黄 色 大片| 日韩在线永久免费播放| 国内揄拍国内精品人妻浪潮av| 亚洲 日韩 国产 有码 不卡| 麻豆国产av超爽剧情系列| 成人性生交大片免费看视频app| 男人撕开奶罩揉吮奶头视频| 亚洲制服有码在线丝袜| 成人网站免费高清视频在线观看| 国产精品成人一区二区三区| 老熟女乱子伦| 欧美性xxxx极品少妇| 国产精品午夜福利不卡| 亚洲成av人片高潮喷水| 日韩电影一区二区三区| 国产精品日韩av在线播放| 亚洲国产午夜精品理论片妓女| 伊人中文字幕无码专区| 精品少妇一区二区三区免费观| 日韩中文字幕在线一区二区三区| 色欲久久人妻内射| 国产啪精品视频网站免| 日本高清色倩视频在线观看| 欧洲熟妇色xxxxx欧美老妇伦| 永久免费的av片在线电影网| 精品国产高清自在线一区二区| 欧美黑人巨大videos精品| 午夜福利一区二区三区在线观看| 免费国产a国产片高清网站| 久久国产欧美成人av| 国产亚洲精品久久yy50| 对白脏话肉麻粗话av| 无翼乌工口全彩肉肉无遮挡18| 免费看国产zzzwww色| 国产精品熟妇一区二区三区四区| 亚洲欧美日韩国产成人精品影院| 久久精品国产精品久久久| 欧美日韩精品一区二区性色a+v| 亚洲色成人中文字幕网站| 欧美亚洲一区二区三区|