在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GRB10 Antibody

GRB10 Antibody

  • 中文名稱：
    GRB10兔多克隆抗體
  • 貨號：
    CSB-PA002806
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of 3T3 cells using GRB10 Polyclonal Antibody
    • Western Blot analysis of NIH-3T3 cells using GRB10 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    grb 10 antibody; GRB IR antibody; grb-10 antibody; GRB10 adapter protein antibody; GRB10 adaptor protein antibody; GRB10 antibody; GRB10_HUMAN antibody; GRBIR antibody; Growth factor receptor bound protein 10 antibody; Growth factor receptor-bound protein 10 antibody; Insulin receptor binding protein antibody; Insulin receptor binding protein GRB IR antibody; Insulin receptor-binding protein Grb-IR antibody; IRBP antibody; KIAA0207 antibody; Maternally expressed gene 1 antibody; MEG1 antibody; RSS antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from Human GRB10 around the non-phosphorylation site of Y67.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.
  • 基因功能參考文獻(xiàn)：
    1. Through syngeneic comparison, our study identifies for the first time that Grb10 is associated with the pluripotency state in nuclear transfer embryonic stem cells. PMID: 28476045
    2. Data suggest that GRB10 and GRB14 are both Ca2+-dependent CaM-binding proteins; more than one CaM-binding site and/or accessory CaM-binding sites appear to exist in GRB10 and GRB14, as compared to a single one present in GRB7. (GRB10 = growth factor receptor-bound protein 10; GRB14 = growth factor receptor-bound protein 14; CaM = calmodulin; GRB7 = growth factor receptor-bound protein 7) PMID: 28295264
    3. GRB10 may regulate degradation of the IL-4 receptor-signaling complex through interactions with NEDD4.2. PMID: 27742835
    4. placental expression associated positively with placental weight, birth weight, and neonatal head circumference PMID: 26390806
    5. Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2 PMID: 27049325
    6. This study demonstrated that the most significant SNP (rs11770199; p = 0.0003) in single-site analysis was located on chromosome 7 in the GRB10 gene. PMID: 25391383
    7. Association of the intronic polymorphism rs12540874 A>G of the GRB10 gene with high birth weight. PMID: 25103788
    8. Tissue-specific methylation and possibly imprinting of GRB10 can influence glucose metabolism. PMID: 24699409
    9. Studies indicate that insulin receptor (IR) and IGF Type 1 Receptor (IGFR) have been identified as important partners of Grb10/14 and SH2B1/B2 adaptors. PMID: 23190452
    10. H19 and GRB10 methylation was normal in Albright's hereditary osteodystrophy patients. PMID: 22679513
    11. discovery of Grb10 as an mTORC1 substrate PMID: 21659604
    12. Grb10 interacts with Bim L and inhibits its proapoptotic activity in a phosphorylation-dependant manner. PMID: 20174874
    13. GRB10 gene is expressed from the paternal allele in the brain, but from the maternal allele in the placental trophoblasts. PMID: 19487367
    14. role in inhibiting insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor PMID: 12493740
    15. The structure of this protein's SH domains affect ligand specificity. PMID: 12551896
    16. Grb10 acts as a positive regulator in VEGF-R2 signaling and protects VEGF-R2 from degradation by interacting with Nedd4, a component of the endocytic machinery PMID: 15060076
    17. GRB10 protein products are correlated with parameters of birth size. PMID: 15506681
    18. there is a phosphorylation-regulated complex formation of Grb10 with 14-3-3 and Akt PMID: 15722337
    19. Up-regulation of growth factor receptor-bound protein 10 is associated with cervical squamous cell carcinoma PMID: 15870923
    20. Ser(150) and Ser(476) of human Grb10zeta are phosphorylated in intact cells. PMID: 15952796
    21. Together, our results suggest that, in addition to inhibiting IR kinase activity by directly binding to the IR, Grb10 also negatively regulates insulin signaling by mediating insulin-stimulated degradation of the receptor. PMID: 16434550
    22. Single nucleotide polymorphism is associated with type 2 diabetes among Whites. PMID: 16644667
    23. GRB10 is a novel negative regulator of the Wnt signaling pathway. The finding that GRB10 interferes with the binding of Axin to LRP6 indicated a possible molecular mechanism by which the overexpression of GRB10 suppresses Wnt signaling. PMID: 17376403
    24. Binds to the Raf-1 and MEK1 kinases. Potential role in the regulation of apoptosis. PMID: 9553107
    25. Role in the regulation of mitogenesis by receptor tyrosine kinases. PMID: 10454568
    26. Mostly localized to the mitochondria. Can relocalize to the plasma membrane and lamellipodia under certain conditions. PMID: 10585452

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    GRB7/10/14 family
  • 組織特異性：
    Widely expressed in fetal and adult tissues, including fetal and postnatal liver, lung, kidney, skeletal muscle, heart, spleen, skin and brain.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4564

    OMIM: 601523

    KEGG: hsa:2887

    STRING: 9606.ENSP00000381793

    UniGene: Hs.164060



主站蜘蛛池模板： 国产在线观看片a免费观看| 日韩精品一区二区三区免费视频 | 亚洲国产天堂久久综合| 国产成人手机高清在线观看网站| 中文字幕无码中文字幕有码a| 国产肉体xxxx裸体784大胆| 精品无码人妻一区二区三区不卡| 日韩国产高清一区二区| 中文字幕v亚洲日本在线电影| 韩国v欧美v亚洲v日本v| 国产av无码专区国产乱码| 国产一区二区三区免费高清在线播放| 中文字幕v亚洲日本在线电影| 亚洲一区二区三区av天堂 | 99精品国产丝袜在线拍国语| 免费床视频大全叫不停欧美| 高级会所人妻互换94部分| 人妻少妇邻居少妇好多水在线| 欧美特级婬片毛多的少妇| 少妇被粗大猛进进出出| 999国内精品永久免费视频 | 97在线成人国产在线视频| 色老99久久精品偷偷鲁| 午夜男女很黄的视频| 久久人妻无码中文字幕| 亚洲精品无码久久久影院相关影片| 真实国产熟睡乱子伦视频| 欧美刺激性大交| 免费观看啪啪黄的网站| 国产亚洲精品久久久久久禁果tv| 国产精品午夜无码av天美传媒| 少妇被粗大的猛进69视频| 国产成人亚洲综合网站小说| 夜夜高潮夜夜爽夜夜爱爱| 国产精品呻吟久久人妻无吗| 成人无码潮喷在线观看| 无码色av一二区在线播放| 特黄大片又粗又大又暴| 久久久久国产精品人妻aⅴ毛片| 国产精品青草久久久久福利99| 欧美人与动性xxxxx杂性|