在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GRAP2 Antibody

  • 中文名稱:
    GRAP2兔多克隆抗體
  • 貨號:
    CSB-PA443192
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HuvEc cells, using GRAP2 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) GRAP2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from internal of Human GRAP2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.
  • 基因功能參考文獻:
    1. These data are consistent with a model in which bivalent recruitment of a GADS/SLP-76 complex is required for costimulation by CD6. PMID: 28289074
    2. Following phosphorylation of the tyrosine, the proteins growth factor receptor-bound protein 2 (Grb2), Grb2-related adaptor downstream of Shc (Gads), and p85 subunit of phosphoinositide 3-kinase may bind to pYMNM (where pY is phosphotyrosine) via their Src homology 2 (SH2) domains, leading to downstream signaling to distinct immune pathways. These three adaptor proteins bind to the same site on CD28 with variable affinity PMID: 27927989
    3. GADS deficient T cells displayed similar levels of T cell receptor -induced SLP-76 and PLC-gamma1 phosphorylation but exhibited substantial decrease in TCR-induced IL-2 and IFN-gamma release. PMID: 25636200
    4. Gads was dispensable for TCR-induced phosphorylation of SLP-76, but was a dose-dependent amplifier of TCR-induced CD69 expression. PMID: 25452106
    5. GADS mediates lymphoid disease downstream of BCR-ABL through the recruitment of specific signaling intermediates. PMID: 23399893
    6. Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL PMID: 21179510
    7. The results show that Bcr-Abl regulates the actin cytoskeleton and non-apoptotic membrane blebbing via a GADS/Slp-76/Nck1 adaptor protein pathway. PMID: 20079431
    8. Upstream open reading frames regulate translation of this protein's mRNA in megakaryocytes. PMID: 12487779
    9. Exogenous expression of GrpL in a GrpL-negative B cell line leads to enhanced antigen receptor-induced extracellular signal-related kinase and p38 mitogen-activated protein kinase phosphorylation. PMID: 12496419
    10. AML-1 plays a role in driving Mona protein expression in T and myelomonocytic cells. PMID: 12554803
    11. Plays a tissue-specific role as an inhibitor of RET receptor tyrosine kinase mitogenic signaling PMID: 12917638
    12. Gads plays a dominant role in CD28-mediated IL-2 promoter activation. PMID: 16818765
    13. The integrity of T-cell receptor signaling in vivo is sustained both by strong selection of SLP-76 for the Gads C-SH3 domain and by a capacity to buffer intrinsic crossreactivity. PMID: 17235283
    14. Consistent Grap-2 expression suggests a specific role for this adaptor in human medullary thyroid carcinoma, while qualitative alterations do not appear to influence RET signaling PMID: 19027225

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm. Endosome.
  • 蛋白家族:
    GRB2/sem-5/DRK family
  • 數據庫鏈接:

    HGNC: 4563

    OMIM: 604518

    KEGG: hsa:9402

    STRING: 9606.ENSP00000339186

    UniGene: Hs.517499



主站蜘蛛池模板: 丰满人妻无码∧v区视频| 无码免费h成年动漫在线观看| 免费无码专区在线视频| 三上悠亚久久精品| 久久99精品久久久久久水蜜桃 | 伊人狼人大焦香久久网| 性一交一乱一伦一| 顶级欧美熟妇高潮xxxxx| 精品人无码一区二区三区| 狠狠色狠狠色综合| 免费久久人人爽人人爽av| 无码人妻精品一区二区蜜桃网站| 亚洲精品国产第一区第二| 动漫无遮挡羞视频在线观看| 国产精品久人妻精品老妇| 人妻在卧室被老板疯狂进入| 成人免费一区二区三区| 国产suv精品一区二区883| 天天狠天天透天干天干| 97色伦综合在线欧美视频| 99久久精品费精品国产一区二| 欧美亚洲精品一区二区 | 午夜熟女插插xx免费视频| 国内揄拍国产精品人妻门事件| 国产成人无码av片在线观看不卡| 成年黄页网站大全免费无码| 巨乳美乳一区二区三区| 在线欧美中文字幕农村电影| 欧美成人看片一区二区三区尤物 | 337p日本欧洲亚洲大胆精筑| 日产精品久久久久久久性色| 日韩成人极品在线内射3p蜜臀| 亚洲女女女同性video| 免费看撕开奶罩揉吮奶头视频| 国产制服丝袜欧美在线观看| 中文字幕亚洲无线码| 亚洲精品av中文字幕在线| 亚洲中文字幕乱码一区| 久久久一本精品99久久精品88| 99精品电影一区二区免费看| 国产揉捏爆乳巨胸挤奶视频|