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  4. GRAP Antibody

GRAP Antibody

  • 中文名稱：
    GRAP兔多克隆抗體
  • 貨號：
    CSB-PA006712
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of 293 cells using Grap Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    GRAP
  • 別名：
    Grap antibody; GRAP_HUMAN antibody; GRB2 related adaptor protein antibody; GRB2-related adapter protein antibody; Growth factor receptor bound protein 2 related adaptor protein antibody; MGC64880 antibody; OTTHUMP00000065766 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human Grap.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing.
  • 基因功能參考文獻：
    1. Findings suggest that the miR-654-5p/GRAP/Ras/Erk signaling pathway in OSCC cells might contribute to the underlying mechanism through which miR-654-5p participates in the regulation of OSCC progression. PMID: 29364705
    2. Grb2-related adaptor protein (GRAP) was up-regulated in kidney tubules from fibrotic kidneys from diabetic patients, and subsequently confirmed as a novel component of TGF-beta signaling in cultured human renal tubule cells. PMID: 19836472
    3. Results suggest that the GRAP gene might have a role in the pathogenesis of Sjogren's syndrome. PMID: 15174222
    4. Our findings define a pathway involving CD28 binding to Grb-2 and its co-operativity with Vav1 in the regulation of T-cell co-stimulation. PMID: 18295596
  • 亞細胞定位：
    Membrane; Peripheral membrane protein. Cell junction, synapse.
  • 蛋白家族：
    GRB2/sem-5/DRK family
  • 數據庫鏈接：

    HGNC: 4562

    OMIM: 604330

    KEGG: hsa:10750

    STRING: 9606.ENSP00000284154

    UniGene: Hs.567416



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