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  4. GPSM3 Antibody, Biotin conjugated

GPSM3 Antibody, Biotin conjugated

  • 中文名稱：
    GPSM3兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA896517LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) GPSM3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GPSM3
  • 別名：
    Activator of G-protein signaling 4 antibody; AGS4 antibody; C6orf9 antibody; G protein signalling modulator 3 (AGS3 like; C. elegans) antibody; G-protein signaling modulator 3 (AGS3-like; C. elegans) antibody; G-protein-signaling modulator 3 antibody; G18 antibody; G18.1a antibody; G18.1b antibody; G18.2 antibody; Gpsm3 antibody; GPSM3_HUMAN antibody; NG1 antibody; OTTHUMP00000029351 antibody; Protein G18 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human G-protein-signaling modulator 3 protein (1-160AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins.
  • 基因功能參考文獻：
    1. role for GPSM3 in neutrophil migration toward proinflammatory chemoattractants LTB4 and CXCL8-a discovery that helps strengthen the association between the promoter-weakening GPSM3 SNP rs204989 and a reduced risk of rheumatoid arthritis PMID: 27307211
    2. Genetic variations in GPSM3 which are associated with protection from rheumatoid arthritis affect its transcript abundance. PMID: 26821282
    3. findings suggest that GPSM3 acts as a direct negative regulator of NLRP3 function. PMID: 25271165
    4. Phosphorylation of GPSM3 by a proline-directed serine/threonine kinase and the resultant association of 14-3-3 is the first description of post-translational regulation of GPSM3 subcellular localization PMID: 22843681
    5. GPSM3 increases Gbeta stability until formation of the Gbetagamma dimer, including association of the Gbeta-GPSM3 complex with phosducin-like protein PhLP and T-complex protein 1 subunit eta (CCT7), two known chaperones of neosynthesized Gbeta subunits. PMID: 22167191
    6. AGS4-Galpha(i) complexes directly couple to a G-protein-coupled receptor and may serve as substrates for agonist-induced G-protein activation. PMID: 20452976
    7. Mutational analysis of the role of GoLoco motifs in guanine nucleotide dissociation inhibitor activity of G18 protein. PMID: 14656218

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  • 亞細胞定位：
    Cytoplasm.
  • 組織特異性：
    Expressed in heart, placenta, lung and liver.
  • 數據庫鏈接：

    HGNC: 13945

    KEGG: hsa:63940

    STRING: 9606.ENSP00000364180

    UniGene: Hs.520046



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