在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GPS2 Antibody, Biotin conjugated

  • 中文名稱:
    GPS2兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA009859LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) GPS2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    GPS2G protein pathway suppressor 2 antibody; GPS-2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human G protein pathway suppressor 2 protein (1-327AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Key regulator of inflammation, lipid metabolism and mitochondrion homeostasis that acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting 'Lys-63'-linked ubiquitination. In the nucleus, can both acts as a corepressor and coactivator of transcription, depending on the context. Acts as a transcription coactivator in adipocytes by promoting the recruitment of PPARG to promoters: acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, leading to stabilization of KDM4A and subsequent histone H3 'Lys-9' (H3K9) demethylation. Promotes cholesterol efflux by acting as a transcription coactivator. Acts as a regulator of B-cell development by inhibiting UBE2N/Ubc13, thereby restricting the activation of Toll-like receptors (TLRs) and B-cell antigen receptors (BCRs) signaling pathways. Acts as a key mediator of mitochondrial stress response: in response to mitochondrial depolarization, relocates from the mitochondria to the nucleus following desumoylation and specifically promotes expression of nuclear-encoded mitochondrial genes. Promotes transcription of nuclear-encoded mitochondrial genes by inhibiting UBE2N/Ubc13. Can also act as a corepressor as part of the N-Cor repressor complex by repressing active PPARG. Plays an anti-inflammatory role in macrophages and is required for insulin sensitivity by acting as a corepressor. Plays an anti-inflammatory role during the hepatic acute phase response by interacting with sumoylated NR1H2 and NR5A2 proteins, thereby preventing N-Cor corepressor complex dissociation. In the cytosol, also plays a non-transcriptional role by regulating insulin signaling and pro-inflammatory pathways. In the cytoplasm, acts as a negative regulator of inflammation by inhibiting the proinflammatory TNF-alpha pathway; acts by repressing UBE2N/Ubc13 activity. In the cytoplasm of adipocytes, restricts the activation of insulin signaling via inhibition of UBE2N/Ubc13-mediated ubiquitination of AKT. Able to suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction. Acts as a tumor-suppressor in liposarcoma.; (Microbial infection) Required for efficient replication of hepatitis C virus (HCV) by promoting the interaction between VAPA and HCV virus protein NS5A.
  • 基因功能參考文獻:
    1. The study of adipose tissue from humans with and without obesity revealed correlations between reduced GPS2 expression in macrophages, elevated systemic and adipose tissue inflammation, and diabetic status. PMID: 27270589
    2. our studies identify GPS2 functions as a tumor suppressor in LPS and its downregulation is correlated to prognosis of LPS. PMID: 27460081
    3. Posttranslational modification of GPS2 by SUMOylation may serve as a key factor that regulates the function of GPS2 in vivo. PMID: 24943844
    4. regulation of GPS2 by posttranslational modifications provides an effective strategy for modulating its molecular function within the nuclear compartment. PMID: 26070566
    5. Chromosomal translocation in a pediatric undifferentiated spindle cell sarcoma have characterized this alteration to show rearrangement of the MLL4 and GPS2 genes, resulting in fusion gene MLL4-GPS2, the expression of which promotes independent growth. PMID: 25139254
    6. GPS2 is required for the association of viral NS5A with VAP-A and hepatitis C virus replication. PMID: 24223774
    7. expression of the transcriptional corepressor complex subunits GPS2 and SMRT was significantly reduced in obese adipose tissue, inversely correlated to inflammatory status PMID: 23221346
    8. Results show for the first time that GPS-2 is differentially methylated at a site that lacks known methylation motifs and that the methylation state is detected by the immune system PMID: 19917673
    9. metabolically important coregulator GPS2 functions as a hitherto unrecognized transrepression mediator of interactions between SUMOylated nuclear receptors and the N-CoR corepressor complex PMID: 20159957
    10. Results show that the N-CoR-HDAC3 complex inhibits JNK activation through the associated GPS2 subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP-1 function. PMID: 11931768
    11. the GPS2 might function in concert with hMSH4-hMSH5 during the process of homologous recombination. PMID: 16122992
    12. Direct interactions of GPS2 with hnf4alpha and farnesoid x receptor indicate alternative coregulator recruitment strategies to cause differential transcriptional outcomes in governing bile acid biosynthesis. PMID: 17895379
    13. GPS2 interacts with RFX4_v3 to modulate transactivation of genes involved in brain morphogenesis, including Cx3Cl1 PMID: 18218630
    14. Data describe the requirement of GPS2 for ABCG1 gene transcription and cholesterol efflux from macrophages, and implicate GPS2 in facilitating LXRalpha/beta recruitment to an ABCG1-specific promoter/enhancer unit upon ligand activation. PMID: 19481530

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Mitochondrion. Cytoplasm, cytosol.
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:

    HGNC: 4550

    OMIM: 601935

    KEGG: hsa:2874

    STRING: 9606.ENSP00000370104

    UniGene: Hs.438219



主站蜘蛛池模板: 大胸美女污污污www网站| 久久无码av中文出轨人妻| 国产在线观看黄av免费| 国产亚洲视频在线播放香蕉| 女被啪到深处喷水gif动态图 | 久久国产av影片| 久久精品国产99精品国产2021| 天堂在线中文网www| 国产精品乱子伦xxxx裸| 久久精品中文字幕有码| 欧美做爰性生交视频| 老湿机69福利区无码| 国产美女午夜福利视频| 人妻插b视频一区二区三区 | 日本少妇裸体做爰高潮片| 伊人色综合久久天天小片| 国产成人亚洲综合青青| 三级网站视频在在线播放| 爽爽影院免费观看| 超碰香蕉人人网99精品| 久久亚洲精品无码av宋| 久久国产成人精品av| 熟妇人妻av无码一区二区三区| 无码综合天天久久综合网| 欧美高清大屁股xxxxx| 大肉大捧一进一出好爽| 少妇高清精品毛片在线视频| 国产成人一区二区无码不卡在线 | 黑人强伦姧人妻久久| 久久久国产精品黄毛片| 国产精品无码久久久久久久久久| 亚洲人成无码网www电影榴莲 | 8ⅹ8x擦拨擦拨成人免费视频| 成人奭片免费观看| 国产999精品久久久久久| 国产精品国产亚洲区艳妇糸列短篇 | 中文字幕日韩人妻在线视频| 亚洲精品av中文字幕在线| 日产欧美国产日韩精品| 人妻少妇精品一区二区三区| 午夜寂寞少妇aaa片毛片|