在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GPRC5A Antibody

  • 中文名稱:
    GPRC5A兔多克隆抗體
  • 貨號(hào):
    CSB-PA070213
  • 規(guī)格:
    ¥1090
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    GPRC5A; GPCR5A; RAI3; RAIG1; Retinoic acid-induced protein 3; G-protein coupled receptor family C group 5 member A; Phorbol ester induced gene 1; PEIG-1; Retinoic acid-induced gene 1 protein; RAIG-1
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human RAI3.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling. May act as a lung tumor suppressor.
  • 基因功能參考文獻(xiàn):
    1. GPRC5a was upregulated in pancreatic cancer (PaCa) leading to an enhanced drug resistance in PaCa cells. PMID: 29949874
    2. under-expressed GPRC5A during lung tumorigenesis enhances any transcriptional stimulation through an active translational status. PMID: 27273304
    3. findings reveal an unprecedented role for GPRC5A in regulation of the ITGB1-mediated cell adhesion and it's downstream signaling, thus indicating a potential novel role for GPRC5A in human epithelial cancers. PMID: 27715394
    4. miR-204 inhibits cell proliferation in gastric cancer by targeting CKS1B, CXCL1 and GPRC5A. PMID: 29283424
    5. p53 overexpression and GPRC5A induction markedly inhibited tumor cell viability and induced apoptosis. PMID: 28849235
    6. GPRC5A is a potential oncogene in pancreatic ductal adenocarcinoma cells that is upregulated by gemcitabine with help from HuR. PMID: 27415424
    7. These results suggest RAI3 plays an important role in adipogenesis of hASCs and may have a potential use in the future application. PMID: 28870805
    8. Study underscores genomic alterations that represent early events in the development of Kras mutant LUAD following Gprc5a loss and tobacco carcinogen exposure. PMID: 28653505
    9. Suppression of GPRC5a results in decreased cell growth, proliferation and migration in pancreatic cancer cell lines via a STAT3 modulated pathway, independent from ERK activation PMID: 28114355
    10. our results implicate GPRC5A as a tumor suppressor in breast cancer cells, and GPRC5A exerts its tumor-suppressive function by inhibiting EGFR and its downstream pathway PMID: 27599526
    11. elevated levels of GPRC5A played significant roles in gastric cancer progression PMID: 26227221
    12. Results show how GPRC5A deficiency leads to dysregulated EGFR and STAT3 signaling and lung tumorigenesis. PMID: 25744720
    13. EGFR interacted with GPRC5A and phosphorylated it in two conserved double-tyrosine motifs, Y317/Y320 and Y347/ Y350, at the C-terminal tail of GPRC5A. PMID: 25311788
    14. The interaction of miR-103a-3p with each of the two 5' UTR targets reduces the expression levels of both GPRC5A mRNA and GPRC5A protein in one normal epithelial and two pancreatic cancer cell lines. PMID: 24984703
    15. RAI3 may contribute to the malignant progression of hepatocellular carcinoma PMID: 23632812
    16. Data indicate that in mammary tumors, the mRNA expression of GPRC5A significantly correlated with that of BRCA1. PMID: 24470238
    17. Decreased GPRC5A expression is associated with non-small cell lung cancers and lung inflammation. PMID: 23154545
    18. Loss of GPRC5A is associated with lung adenocarcinomas. PMID: 20563252
    19. RAI3 is a cell growth-promoting gene and a novel P53 transcriptional target PMID: 15659406
    20. This evidence explains one of the mechanisms of the GPRC5A-regulated cell growth in some cancer cell lines. PMID: 17055459
    21. Gprc5a functions as a tumor suppressor in mouse lung, and human GPRC5A may share this property. PMID: 18000218
    22. Mechanisms underlying the induction of the putative human tumor suppressor GPRC5A are reported. PMID: 19279407
    23. analysis of RAI3 expression in normal and cancerous human breast tissue at both the mRNA and protein levels PMID: 19552806

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 3 family
  • 組織特異性:
    Expressed at high level in fetal and adult lung tissues but repressed in most human lung cancers. Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal chord at low to mod
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 9836

    OMIM: 604138

    KEGG: hsa:9052

    STRING: 9606.ENSP00000014914

    UniGene: Hs.631733



主站蜘蛛池模板: 99精品国产一区二区三区不卡 | 国产熟女亚洲精品麻豆| 日本不卡高字幕在线2019| 国产精品日日做人人爱| 无码精品a∨在线观看无广告| 天堂在线最新版资源www| 永久黄网站色视频免费看| 国产精品高清网站| 国产精品18久久久久久vr | 精品无人码麻豆乱码1区2区| 久久精品麻豆日日躁夜夜躁| 国产成人精品男人的天堂| 无码国模国产在线观看免费| 韩国三级hd中文字幕叫床| 狠狠色丁香久久婷婷综合蜜芽五月 | 五十路丰满中年熟女中出| 亚洲日本va中文字幕久久| 国产精品天干天干综合网| 国产精品美女乱子伦高| 亚洲欧洲国产综合aⅴ无码| 天天天天躁天天爱天天碰| 文中字幕一区二区三区视频播放 | 国产成人精品三级在线影院| 国产人妻精品一区二区三首| 人妻无码第一区二区三区| 亚洲人成在线观看| 国产a三级久久精品| 午夜嘿嘿嘿在线观看| 免费人成小说在线观看网站| 国产精品无码不卡一区二区三区 | 国产精品线路一线路二| 亚洲精品nv久久久久久久久久| 日本少妇裸体做爰高潮片| 无码人妻精品中文字幕不卡| 国产肉丝袜视频在线观看| 国产精品麻豆成人av电影艾秋| 风韵丰满熟妇啪啪区老熟熟女| 国产成+人+综合+亚洲欧美丁香花| 大狠狠大臿蕉香蕉大视频| 精品无码国产自产拍在线观看| 国内精品免费久久久久电影院 |