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  4. GPR87 Antibody

GPR87 Antibody

  • 中文名稱：
    GPR87兔多克隆抗體
  • 貨號：
    CSB-PA005771
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of K562 cells using GPR87/95 Polyclonal Antibody.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    GPR87; GPR95; FKSG78; G-protein coupled receptor 87; G-protein coupled receptor 95
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human GPR87/95.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage.
  • 基因功能參考文獻(xiàn)：
    1. the basal activity of GPR87 was investigated. PMID: 27865873
    2. we reported that GPR87 expression was significantly upregulated in pancreatic cancer, and higher GPR87 correlated with shorter overall survival of patients with pancreatic cancer. PMID: 28288630
    3. knockdown of GPR87 led to a p53-dependent signal transduction and caused apoptosis in the bladder cancer cells. PMID: 26473854
    4. This study aimed to clarify the role of GPR87 in urothelial carcinoma of the bladder. PMID: 23752273
    5. GPR87 promotes the growth and metastasis of CD133(+) cancer stem-like cells, and our findings may reveal new targets for HCC prevention or therapy PMID: 23593389
    6. Results suggest that the GPR87 is a LPA receptor which evolved from a common ancestor of P2Y receptors. PMID: 17905198
    7. G-protein coupled receptor(GPR87) stands out as a candidate for further target validation due to its marked overexpression and correlation on a mutation-based level to squamous cell carcinoma PMID: 18057535
    8. Human GPR87 mRNA transcript was preferentially overexpressed in squamous cell carcinomas. Up-regulation of both, transcript and protein, was detected in samples of SCC of the lung, cervix, skin and head and neck (pharynx, larynx and epiglottis). PMID: 18183596
    9. GPR87 knockdown sensitized cancer cells to DNA damage-induced growth suppression via enhanced p53 stabilization and activation. PMID: 19602589

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  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 組織特異性：
    Expressed in placenta and prostate. Weaker expression in thymus. Not expressed in thalamus, hippocampus, pons or cerebellum. Overexpressed in squamous cell carcinoma of the lung.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4538

    OMIM: 606379

    KEGG: hsa:53836

    STRING: 9606.ENSP00000260843

    UniGene: Hs.591292



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