在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GPR65 Antibody

GPR65 Antibody

  • 中文名稱：
    GPR65兔多克隆抗體
  • 貨號：
    CSB-PA548371
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA548371(GPR65 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA548371(GPR65 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    GPR65; TDAG8; Psychosine receptor; G-protein coupled receptor 65; T-cell death-associated gene 8 protein
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human GPR65
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. Plays a role in immune response by maintaining lysosome function and supporting phagocytosis-mediated intracellular bacteria clearance. May have a role in activation-induced cell death or differentiation of T-cells.
  • 基因功能參考文獻：
    1. TDAG8 functions as a contextual tumor suppressor down-regulated in hematological malignancies. PMID: 29017562
    2. Study results suggest greater T cell death associated gene-8 (TDAG8) expression in patients with panic disorder compared to healthy subjects, and directly link TDAG8 expression and the severity of the panic disorder symptoms PMID: 28736033
    3. this study establishes a role for GPR65 in inflammatory bowel disease susceptibility and identify lysosomal dysfunction as a potentially causative element in pathogenesis PMID: 27287411
    4. TDAG8 expression is decreased by more than 50%. PMID: 24152439
    5. GPR65 is a regulator upstream of MMP3, which is regulated by proton-sensing G-protein-coupled receptors PMID: 23707809
    6. Acidosis promotes Bcl-2 family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor Gpr65 signaling to Mek/Erk. PMID: 22685289
    7. Data suggest that one physiological function of TDAG8 is negative regulation of inflammation by inhibiting production of pro-inflammatory cytokines in T-lymphocytes and macrophages. PMID: 22445881
    8. These results support the hypothesis that TDAG8 enhances tumor development by promoting adaptation to the acidic environment to enhance cell survival/proliferation. PMID: 20855608
    9. GPR4 and TDAG8 overexpression in human tumors plays a role in driving or maintaining tumor formation PMID: 15221007
    10. TDAG8 is one of the proton-sensing GPCRs coupling to adenylyl cyclase and psychosine, and its related lysosphingolipids behave as if they were antagonists against protein-sensing receptors, including TDAG8, GPR4, and OGR1. PMID: 15326175
    11. TDAG8 may play biological roles in immune response and cellular transformation under conditions accompanying tissue acidosis. PMID: 15618224
    12. Expression of TDAG8 by immune cells may regulate responses in acidic microenvironments. PMID: 15665078
    13. At least partly, TDGA8 mediates extracellular acidification-induced inhibition of proinflammatory cytokine production through the Gs protein/cyclic AMP-dependent protein kinase A signaling pathway in transgenic mouse macrophages. PMID: 19234222

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 組織特異性：
    Predominantly expressed in thymus, spleen, lymph nodes, small intestine, lung, placenta and peripheral blood leukocytes.
  • 數據庫鏈接：

    HGNC: 4517

    OMIM: 604620

    KEGG: hsa:8477

    STRING: 9606.ENSP00000267549

    UniGene: Hs.443243



主站蜘蛛池模板： 人妻无码中文专区久久五月婷 | 国产清纯美女遭强到高潮| 亚洲vs成人无码人在线观看堂| 国产精品 中文字幕 亚洲 欧美| aⅴ亚洲 日韩 色 图网站 播放| 日本猛少妇色xxxxx猛叫| 在线天堂中文在线资源网| 中国熟妇浓毛hdsex| 亚洲精品色播一区二区| 国产午夜福利小视频合集| 中文字幕人成人乱码亚洲电影| 精品深夜av无码一区二区| 亚洲中文字幕无码日韩| 欧美黑人xxxx又粗又长| 国产在线观看无码不卡 | 性色av一区二区三区无码| 亚洲精品字幕| 99久久国产露脸精品| 粉嫩大学生无套内射无码卡视频| 久久久久久a亚洲欧洲av冫| 国产精品无码免费专区午夜| 青草影院内射中出高潮| 久久99国产精品二区| 少妇大叫太大太爽受不了| 免费又黄又爽又色的视频| 人人妻人人澡人人爽欧美一区九九| 午夜国人精品av免费看| 亚洲精品伊人久久久大香| 国产成人无码av一区二区在线观看| 女人高潮流白浆视频| 色伊人亚洲综合网站| 日韩精品专区在线影院重磅| 亚洲色爱图小说专区| 色综合久久精品亚洲国产| 成人试看30分钟免费视频| 国产精品亚洲综合色区| 日本少妇被黑人猛cao| 躁躁躁日日躁| 日韩去日本高清在线| 成人网站免费高清视频在线观看 | 嫖妓大龄熟妇正在播放|