在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GPR35 Antibody

  • 中文名稱:
    GPR35兔多克隆抗體
  • 貨號:
    CSB-PA009808GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    GPR35; G-protein coupled receptor 35; Kynurenic acid receptor; KYNA receptor
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Human GPR35
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.
  • 基因功能參考文獻:
    1. We performed a label-free kinome short hairpin RNA screen and identified a putative signaling network of GPR35 in HT-29 cells, some of which was validated using gene expression, biochemical and cellular assays. The results showed that GPR35 induced hypoxia-inducible factor 1alpha, and was involved in synaptic transmission, sensory perception, the immune system, and morphogenetic processes. PMID: 28425521
    2. Using exome array data, we identified GPR35 as a novel susceptibility gene associated with chronic AIC in pediatric cancer patients PMID: 28961156
    3. GPR35 interacts with CXCL17 in breast cancer cells. PMID: 28943434
    4. Small molecules that stimulate or block GPR35 activity can modulate vascular proliferation and migration. PMID: 27064272
    5. This article shows that GPR35 is the receptor of CXCL17. PMID: 25411203
    6. Single-nucleotide polymorphism in GPR35 gene is associated with Crohn's disease. PMID: 25489960
    7. results clearly show that R4.60, R(164), R(167), and R6.58 play crucial roles in the agonist initiated activation of GPR35. PMID: 24347166
    8. GPR35 shows associations in both ulcerative colitis (UC) and primary sclerosing cholangitis (PSC), whereas TCF4 represents a PSC risk locus not associated with UC. Both loci may represent previously unexplored aspects of PSC pathogenesis. PMID: 22821403
    9. This review presents a summary of what is known about the G-protein coupled receptors GPR35 and GPR55 and their potential characterization as lysophospholipid or cannabinoid receptors, respectively--{REVIEW} PMID: 22820167
    10. screening assays used to identification of small MW agonists; some compounds are species-specific agonists; agonists/ligands include zaprinast, cromolyn & dicumarol PMID: 20919992
    11. human iNKT cells express GPR35 functionally active in reducing IL-4 release. PMID: 20599711
    12. These results strongly suggest that 2-acyl lysophosphatidic acid is an endogenous ligand for GPR35. PMID: 20361937
    13. The results of the study demonstrate the coupling of GPR35 to endogenous G proteins that modulate neuronal Ca2+ channel and thereby provide evidence for a potential role of GPR35 in regulating neuronal excitability and synaptic transmission PMID: 17940199

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Note=Internalized to the cytoplasm after exposure to kynurenic acid.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Predominantly expressed in immune and gastrointestinal tissues.
  • 數據庫鏈接:

    HGNC: 4492

    OMIM: 602646

    KEGG: hsa:2859

    STRING: 9606.ENSP00000415890

    UniGene: Hs.112218



主站蜘蛛池模板: 国产精品女主播在线视频| 久久av无码精品人妻糸列| 熟女少妇丰满一区二区| 国产午夜福利短视频| 日本熟妇人妻xxxxx| 粉嫩被粗大进进出出视频| 婷婷色香五月综合缴缴情| 亚洲乱色熟女一区二区三区丝袜| 国模吧无码一区二区三区| 97人妻人人做人碰人人爽| 人人妻人人澡人人爽国产| 国产一区二区亚洲精品| 国产交换配乱婬视频| 香蕉视频在线观看亚洲| 国产成人无码精品久久久免费| 99国产欧美另类久久久精品| 无码专区手机在线播放| 国产日韩在线视看第一页| 国产精品精华液网站| 天天澡天天揉揉av在线| 茄子在线看片免费人成视频| 国产精品亚洲色婷婷99久久精品| 人妻奶水人妻系列| 无码精品久久久久久人妻中字| 国精品人妻无码一区二区三区性色| 亲子乱子伦xxxx视频| 无码aⅴ精品一区二区三区浪潮 | 日本午夜免费福利视频| 免费香蕉成视频人网站| 成人无码精品免费视频在线观看| 国产男女猛烈无遮挡免费视频网站| 无码人妻熟妇av又粗又大| 久久婷婷五月综合色和| 免费看国产成年无码av| 亚洲欧美日韩一区二区| 久久午夜夜伦鲁鲁片免费无码| 人人模人人爽人人喊久久| 日本一卡2卡3卡4卡免费乱码网站| 一边吃奶一边摸做爽视频| 久久国产精品成人影院| 丁香五月激情综合国产|