在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GPHN Antibody, HRP conjugated

  • 中文名稱:
    GPHN兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA009716LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) GPHN Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    GPHN
  • 別名:
    Domain E antibody; Domain G antibody; GEPH antibody; GEPH_HUMAN antibody; GPH antibody; GPHN antibody; GPHRYN antibody; KIAA1385 antibody; Molybdopterin molybdenumtransferase antibody; MPT adenylyltransferase antibody; MPT Mo-transferase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Gephyrin protein (360-460AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors.; Has also a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
  • 基因功能參考文獻:
    1. This study shown that the SNPs located in the rs723432 (Pallele=0.007; uncorrected) in the GPHN gene showed associated with Japanese individuals affected with schizophrenia. PMID: 28073605
    2. these data reveal that IQSEC3 acts together with gephyrin to regulate inhibitory synapse development. PMID: 27002143
    3. A missense mutation of gephyrin that was unable to synthesize MoCo and activate MoCo-dependent enzymes was identified. PMID: 26613940
    4. A yin-yang haplotype pattern encompassing gephyrin consists of 284 divergent nucleotide states and both variants vary drastically from their mutual ancestral haplotype, suggesting rapid evolution. PMID: 25813846
    5. The N-terminal region of GABRA3 and the GlyR beta subunit occupies the same binding site of gephyrin. PMID: 25531214
    6. Results show that PKC-dependent phosphorylation of GAP43 plays a critical role in regulating postsynaptic gephyrin aggregation in developing GABAergic synapses. PMID: 25755278
    7. Structural exonic microdeletions affecting the GPHN gene constitute a rare genetic risk factor for IGE and other neuropsychiatric disorders by an impairment of the GABAergic inhibitory synaptic transmission. PMID: 24561070
    8. The enhancement of Cb-induced gephyrin clustering by GTP-TC10 does not depend on the guanine nucleotide exchange activity of Cb but involves an interaction that resembles reported interactions of other small GTPases with their effectors PMID: 24297911
    9. abnormal accumulations of gephyrin are highly correlated with the neuropathologic diagnosis of Alzheimer disease in 17 AD versus 14 control cases. Furthermore, gephyrin accumulations were specific for AD. PMID: 24128675
    10. Rare exonic deletions implicate the synaptic organizer Gephyrin (GPHN) in risk for autism, schizophrenia and seizures. PMID: 23393157
    11. Extracellular signal-regulated kinase and glycogen synthase kinase 3beta regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism PMID: 23408424
    12. A reduction in the number of gephyrin clusters in primary neurons reduces GABA signaling. PMID: 23077067
    13. Phosphorylation of gephyrin in hippocampal neurons by cyclin-dependent kinase CDK5 at Ser-270 is dependent on collybistin. PMID: 22778260
    14. The gephyrin's presence in a cytosolic 600 kDa protein complex suggests that its metabolic and/or other non-neuronal functions are exerted in the cytoplasm and are not confined to a particular subcellular compartment. PMID: 22270318
    15. Gephyrin expression is significantly lower in the temporal neocortex of temporal lobe epilepsy (TLE) patients and may be involved in the development of TLE. PMID: 21404332
    16. The authors have identified a protein kinase C (PKC) phosphorylation site within the cytoplasmic domain of the beta-subunit of the GlyR (residue S403) that causes a reduction of the binding affinity between the receptor and gephyrin. PMID: 21829170
    17. Data demonstrate the direct interaction between DYNLL1 and peptides derived from ASFV p54 and gephyrin interacting sequences. PMID: 21094642
    18. we did not obtain evidence for gephyrin gene mutations in patients with temporal lobe epilepsy PMID: 21071388
    19. Data are consistent with the postsynaptic gephyrin scaffold acting as a platform for protein phosphatase 1 (PP1), which regulates gephyrin cluster size by dephosphorylation of gephyrin- or cytoskeleton-associated proteins. PMID: 20206270
    20. Study propose that the collybistin-gephyrin complex has an intimate role in the clustering of GABA(A)Rs containing the alpha2 subunit. PMID: 20622020
    21. Gephyrin plays a role in synaptic function by interacting with GRIP1 splice forms at GABAergic synapses in transfected cultured hippocampal neurons. PMID: 18315564
    22. Gephyrin may have a central organizer role in assembling and stabilizing inhibitory postsynaptic membranes in human brain and is similar in function to those observed in the rodent brain. PMID: 12535948
    23. the N10Y mutation and alternative splicing of GPHN transcripts do not affect interactions with glycine receptor but may affect other interactions with the cytoskeleton or gephyrin accessory proteins PMID: 12684523
    24. Review: A total of 32 different disease-causing mutations, including several common to more than one family, have been identified in molybdenum cofactor-deficient patients and their relatives PMID: 12754701
    25. Colocalization of immunoreactivities for gephyrin and glycine receptor subunits was detected in the dorsal and ventral horns of the spinal cord, the hypoglossal nucleus and the medial vestibular nucleus of the medulla. PMID: 14622920
    26. GPHN as an MLL-GPHN chimera is able to transform hematopoietic progenitors; a tubulin-binding domain of GPHN is necessary and sufficient for this activity and also confers oligomerization capacity on MLL protein, which may contribute to leukemogenesis PMID: 14751928
    27. Within clusters, we identified two subpopulations of GlyR with distinct degrees of stabilization between receptors and scaffolding proteins. PMID: 17293395
    28. crystal structure of N terminal G domain PMID: 11554796

    顯示更多

    收起更多

  • 相關疾病:
    Molybdenum cofactor deficiency, complementation group C (MOCODC)
  • 亞細胞定位:
    Cell junction, synapse, postsynaptic cell membrane; Lipid-anchor; Cytoplasmic side. Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell projection, dendrite. Cell junction, synapse, postsynaptic density.
  • 蛋白家族:
    MoaB/Mog family; MoeA family
  • 數據庫鏈接:

    HGNC: 15465

    OMIM: 603930

    KEGG: hsa:10243

    STRING: 9606.ENSP00000417901

    UniGene: Hs.208765



主站蜘蛛池模板: aaaaa少妇高潮大片| 天天爽夜夜爽人人爽曰| 少妇性饥渴无码a区免费| 一本一道精品欧美中文字幕| 99日本精品永久免费久久| 秋霞午夜一区二区三区黄瓜视频| 国产精品v片在线观看不卡| 久久久久久人妻一区二区三区| 亚洲女教师丝祙在线播放| 粗大的内捧猛烈进出看视频| 青青草原精品99久久精品66| 欧洲熟妇色xxxxx欧美老妇伦| 无码熟熟妇丰满人妻啪啪 | 国精品99久9在线 | 免费| 国产精品白丝av网站在线观看| 精品国产欧美一区二区| 久久亚洲精品无码播放| 国产美女口爆吞精普通话| 色一情一乱一乱一区99av白浆| 97精品久久久久中文字幕| 精品亚洲国产成人av在线时间短的| 久久理论片午夜琪琪电影院| 性做久久久久久久| 亚洲日韩av无码一区二区三区 | 国产熟妇另类久久久久久| 国产精品人妻久久久久| 成人无码一区二区三区| 秋霞鲁丝片av无码| 日韩精品少妇无码受不了| 亚洲成a人片在线观看无码专区| 中文幕无线码中文字蜜桃| 蜜桃av亚洲精品一区二区| 国产精品久久毛片| 亚洲日韩中文第一精品| 人妻中文字幕无码系列| 国产精品99久久久久久宅男小说 | 强制高潮18xxxxhd日韩| 欧美乱人伦人妻中文字幕| 国产精品99久久精品| 羞涩的丰满人妻40p| 无码aⅴ精品一区二区三区|