在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GP Antibody, HRP conjugated

Rare Species
  • 中文名稱:
    GP兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA310843LB01ZAA
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Zaire ebolavirus GP Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    GP
  • 別名:
    GP antibody; Envelope glycoprotein antibody; GP1,2 antibody; GP) [Cleaved into: GP1; GP2; GP2-delta] antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Zaire ebolavirus
  • 免疫原:
    Recombinant Zaire ebolavirus Envelope glycoprotein (502-637AA)
  • 免疫原種屬:
    Zaire ebolavirus
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Trimeric GP1,2 complexes form the virion surface spikes and mediate the viral entry processes, with GP1 acting as the receptor-binding subunit and GP2 as the membrane fusion subunit. At later times of infection, downregulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion. Down-modulates several integrins including ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGAV and ITGB1. This decrease in cell adhesion molecules may lead to cell detachment, contributing to the disruption of blood vessel integrity and hemorrhages developed during infection (cytotoxicity). Interacts with host TLR4 and thereby stimulates the differentiation and activation of monocytes leading to bystander death of T-lymphocytes. Downregulates as well the function of host natural killer cells. Counteracts the antiviral effect of host BST2/tetherin that restricts release of progeny virions from infected cells. However, cooperates with VP40 and host BST2 to activate canonical NF-kappa-B pathway in a manner dependent on neddylation.; Functions as a decoy for anti-GP1,2 antibodies thereby contributing to viral immune evasion. Interacts and activates host macrophages and dendritic cells inducing up-regulation of cytokine transcription. This effect is mediated throught activation of host TLR4.; Responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into dendritic cells (DCs) and endothelial cells. Binding to the macrophage specific lectin CLEC10A also seems to enhance virus infectivity. Interaction with FOLR1/folate receptor alpha may be a cofactor for virus entry in some cell types, although results are contradictory. Members of the Tyro3 receptor tyrosine kinase family also seem to be cell entry factors in filovirus infection. Once attached, the virions are internalized through clathrin-dependent endocytosis and/or macropinocytosis. After internalization of the virus into the endosomes of the host cell, proteolysis of GP1 by two cysteine proteases, CTSB/cathepsin B and CTSL/cathepsin L removes the glycan cap and allows GP1 binding to the host entry receptor NPC1. NPC1-binding, Ca(2+) and acidic pH induce a conformational change of GP2, which unmasks its fusion peptide and permit membranes fusion.; Acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in GP2, releasing the fusion hydrophobic peptide.
  • 亞細胞定位:
    [GP2]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein.; [GP1]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein.; [Shed GP]: Secreted.
  • 蛋白家族:
    Filoviruses glycoprotein family


主站蜘蛛池模板: 久久久久四虎精品免费入口| 欧美丰满熟妇xxxx性大屁股| 国产亚洲精品一区二区三区| 国产精品视频白浆免费视频| 无人区码一码二码三码区别新月| 国产熟妇人妻精品一区二区动漫| 国产成人无码av一区二区| 国产特黄级aaaaa片免| 摸丰满大乳奶水www免费| 中文中幕a在线| 精品午夜福利在线视在亚洲| 精品国产乱码久久久软件下载| 精品无码av无码免费专区| 亚洲成a人片在线不卡一二三区| 激情毛片无码专区| 久久精品人人爽人人爽| 无码人妻一区二区三区免费n鬼逝| 色欲国产麻豆一精品一av一免费| 波多野结衣在线播放| 亚洲国内精品自在线影院| 蜜桃av蜜臀av色欲av麻| 亚洲另类激情综合偷自拍图| 国产综合久久久久| 久久久久久久岛国免费观看 | 婷婷五月深深久久精品| 国产精品国产自线拍免费不卡 | www国产精品内射老师| 在线成人a毛片免费播放| 亚洲欧美不卡高清在线观看| 三上悠亚久久精品| 久久人人爽人人爽人人片av麻烦| 久久熟妇人妻午夜寂寞影院| 18禁黄网站禁片免费观看女女| 无码人妻aⅴ一区二区三区69岛| 国产精品久久久久久久| 成年美女黄的视频网站| 无码纯肉动漫在线观看| 97久久精品人妻人人搡人人玩| 精品无人区一区二区三区| 伊人久久大香线蕉综合bd高清| 国产精品一区二区久久不卡|