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  4. GNPAT Antibody

GNPAT Antibody

  • 中文名稱：
    GNPAT兔多克隆抗體
  • 貨號：
    CSB-PA009629LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA009629LA01HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) GNPAT Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GNPAT
  • 別名：
    Acyl CoA dihydroxyacetonephosphateacyltransferase antibody; Acyl-CoA:dihydroxyacetonephosphateacyltransferase antibody; DAP AT antibody; DAP-AT antibody; DAPAT antibody; DHAP AT antibody; DHAP-AT antibody; DHAPAT antibody; Dihydroxyacetone phosphate acyltransferase antibody; EC 2.3.1.42 antibody; Glycerone-phosphate O-acyltransferase antibody; Glyceronephosphate O acyltransferase antibody; GNPAT antibody; GNPAT_HUMAN antibody; OTTHUMP00000036147 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Dihydroxyacetone phosphate acyltransferase protein (589-680AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，GNPAT Antibody (CSB-PA009629LA01HU)，的標記方式是Non-conjugated。對于GNPAT Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA009629LB01HU GNPAT Antibody, HRP conjugated ELISA
    FITC CSB-PA009629LC01HU GNPAT Antibody, FITC conjugated
    Biotin CSB-PA009629LD01HU GNPAT Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Dihydroxyacetonephosphate acyltransferase involved in plasmalogen biosynthesis.
  • 基因功能參考文獻：
    1. GNPAT p.D519G is strongly associated with markedly increased iron stores in p.C282Y homozygotes after correction for age, iron-related variables, and alcohol consumption. PMID: 27936396
    2. GNPAT rs11558492 is not a major modifier of iron status and is not associated with liver fibrosis in HFE-related Hemochromatosis patients. PMID: 28425416
    3. Here, we report the characterization of the recombinant human DHAP acyl-transferase, which performs the first step in alkyl-DHAP synthesis. PMID: 27836547
    4. Reduction of GNPAT activated NF-kappaB in glial cell lines and microglia in cortex. PMID: 28292831
    5. C282Y homozygotes referred for HFE testing commonly have a GNPAT variant. This GNPAT variant does not appear be a co-modifying gene affecting expression of HFE related hemochromatosis in this population. The GNPAT variant does not predict the severity of iron overload. PMID: 27740525
    6. The variant of the GNPAT gene showed the most significant association with severe iron overload. PMID: 25605615
    7. ACOX1 and GNPAT silencing up-regulated ceramide galactosyltransferase (UGT8) mRNA expression, and down-regulated UDP-glucoseceramide glucosyltransferase (UGCG). PMID: 23933200
    8. Novel mutations in GNPAT cause rhizomelic chondrodysplasia punctata (RCDP) type 2. PMID: 21990100
    9. peroxisomal DHAPAT is essential for the biosynthesis of plasmalogens in animal cells PMID: 15687349
    10. Chromosome 1q42.1 harbors GNPAT and DISC1 as candidate genes for schizophrenia. PMID: 16997000

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  • 相關疾病：
    Rhizomelic chondrodysplasia punctata 2 (RCDP2)
  • 亞細胞定位：
    Peroxisome membrane; Peripheral membrane protein; Matrix side.
  • 蛋白家族：
    GPAT/DAPAT family
  • 數據庫鏈接：

    HGNC: 4416

    OMIM: 222765

    KEGG: hsa:8443

    STRING: 9606.ENSP00000355607

    UniGene: Hs.498028



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