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  4. GNG7 Antibody

GNG7 Antibody

  • 中文名稱：
    GNG7兔多克隆抗體
  • 貨號：
    CSB-PA009619LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunofluorescence staining of MCF-7 cells with CSB-PA009619LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) GNG7 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    GNG7 antibody; GNGT7 antibody; Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 protein (2-65AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，GNG7 Antibody (CSB-PA009619LA01HU)，的標記方式是Non-conjugated。對于GNG7 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA009619LB01HU GNG7 Antibody, HRP conjugated ELISA
    FITC CSB-PA009619LC01HU GNG7 Antibody, FITC conjugated
    Biotin CSB-PA009619LD01HU GNG7 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum.
  • 基因功能參考文獻：
    1. GNG7 is a highly specific promoter methylated gene associated with head and neck cancer. PMID: 23403885
    2. Loss of GNG7 protein expression is a frequent event in head and neck cancer with hypermethylation of the promoter region of GNG7 being probably the mechanism for the observed inactivation. PMID: 22183866
    3. Reduced expression of G-gamma 7 is associated with the histological grade of EHCC and may prove to be a useful marker for predicting the prognosis of human EHCC. PMID: 20543539
    4. GNG7 suppression represents a new prognostic indicator in cases of oesophageal cancer. PMID: 18219292
  • 亞細胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    G protein gamma family
  • 組織特異性：
    Expressed in a variety of tissues. Down-regulated in pancreatic and esophageal cancer.
  • 數據庫鏈接：

    HGNC: 4410

    OMIM: 604430

    KEGG: hsa:2788

    STRING: 9606.ENSP00000371594

    UniGene: Hs.515544



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