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  4. GNB4 Antibody, FITC conjugated

GNB4 Antibody, FITC conjugated

  • 中文名稱：
    GNB4兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA862056LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) GNB4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    G protein beta 4 subunit antibody; GBB4_HUMAN antibody; GNB 4 antibody; Gnb4 antibody; Guanine nucleotide binding protein (G protein) beta polypeptide 4 antibody; Guanine nucleotide binding protein beta 4 subunit antibody; Guanine nucleotide binding protein beta polypeptide 4 antibody; Guanine nucleotide binding protein beta subunit 4 antibody; Guanine nucleotide binding protein subunit beta 4 antibody; Guanine nucleotide-binding protein subunit beta-4 antibody; Transducin beta chain 4 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Guanine nucleotide-binding protein subunit beta-4 protein (105-185AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
  • 基因功能參考文獻：
    1. GNB4 is important for growth of breast cancer cells and a potential target for treatment PMID: 30103729
    2. A novel missense GNB4 variant causes Charcot-Marie-Tooth disease F in two patients, who represent the first record of the disease in the Japanese population. PMID: 28642160
    3. Suggest Gbeta4gamma1 as a modulator of M3 muscarinic receptor signaling. PMID: 25916507
    4. Analysis of GNB4 in an additional 88 unrelated CMT individuals uncovered another de novo mutation. PMID: 23434117
    5. Gbeta4 subunit is coexpressed in physiologically ON-type cone bipolar cells with Ggamma13 and Gbeta3 but is not present in OFF-type bipolar cells. PMID: 12454992
    6. Gbeta4 is widely expressed, located on chromosome 3 with a genomic structure like Gbeta1 to Gbeta3, but different from Gbeta5 PMID: 12782285
    7. Intron-1 haplotypes of GNB4 may, thus, serve as predictive markers for progression and survival of patients suffering from bladder cancer. PMID: 18815590
    8. Intron-1 haplotypes of GNB4 is associated with colorectal carcinoma. PMID: 19414374

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  • 相關疾病：
    Charcot-Marie-Tooth disease, dominant, intermediate type, F (CMTDIF)
  • 蛋白家族：
    WD repeat G protein beta family
  • 組織特異性：
    Strongly expressed in lung and placenta, whereas it is weakly expressed in brain and heart. Abundantly expressed in the axons and Schwann cells of peripheral nerves.
  • 數據庫鏈接：

    HGNC: 20731

    OMIM: 610863

    KEGG: hsa:59345

    STRING: 9606.ENSP00000232564

    UniGene: Hs.173030



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