在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GNB1 Antibody

  • 中文名稱:
    GNB1兔多克隆抗體
  • 貨號:
    CSB-PA009602LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: Rat brain tissue, Mouse brain tissue
      All lanes: GNB1 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 38, 37 kDa
      Observed band size: 38 kDa
    • Immunofluorescent analysis of HepG2 cells using CSB-PA009602LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) GNB1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Beta subunit signal transducing proteins GS/GI antibody; G protein beta 1 subunit antibody; GBB1 antibody; GBB1_HUMAN antibody; gnb1 antibody; Guanine nucleotide binding protein (G protein) beta polypeptide 1 antibody; Guanine nucleotide binding protein beta 1 subunit antibody; Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 antibody; Transducin beta chain 1 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human, Mouse, Rat
  • 免疫原:
    Recombinant Human Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 protein (157-248AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,GNB1 Antibody (CSB-PA009602LA01HU),的標(biāo)記方式是Non-conjugated。對于GNB1 Antibody,我們還提供其他標(biāo)記。見下表:

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA009602LB01HU GNB1 Antibody, HRP conjugated ELISA
    FITC CSB-PA009602LC01HU GNB1 Antibody, FITC conjugated
    Biotin CSB-PA009602LD01HU GNB1 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
  • 基因功能參考文獻(xiàn):
    1. Mutation in the GNB1 gene is associated with neurodevelopmental disorder and cutaneous mastocytosis. PMID: 29174093
    2. Through analysis of the genomic and proteomic profiles of resistant cells, we identified an acquired mutation in the GNB1 gene, K89M, as the most likely cause of the resistance PMID: 28650474
    3. Germline De Novo Mutations in GNB1 Cause Severe Neurodevelopmental Disability, Hypotonia, and Seizures. PMID: 27108799
    4. we demonstrate a pathogenic role of de novo and autosomal dominant mutations in GNB1 as a cause of Global developmental delay and provide insights how perturbation in heterotrimeric G protein function contributes to the disease PMID: 28087732
    5. PhLP1 binding stabilizes the Gbeta fold, disrupting interactions with CCT and releasing a PhLP1-Gbeta dimer for assembly with Ggamma. PMID: 25675501
    6. GNB1 and GNB2 alterations confer transformed and resistance phenotypes across a range of human tumors and may be targetable with inhibitors of G protein signaling. PMID: 25485910
    7. During corticogenesis, a cilium-transduced, noncanonical IGF-1R-Gbetagamma-phospho(T94)Tctex-1 signaling pathway promotes the proliferation of neural progenitors through modulation of ciliary resorption and G1 length. PMID: 23954591
    8. GNB1 plays an important role in the mTOR-related anti-apoptosis pathway and can potentially be targeted in the treatment of human breast cancer. PMID: 23603342
    9. Findings suggest a wide-ranging mechanism by which direct interaction of Gbetagamma with specific chromatin bound transcription factors regulates functional gene networks in response to GPCR activation in cells including the angiotensin II type 1 receptor. PMID: 23326349
    10. This study provided evidence that GNB1 gene polymorphisms are related to rapid virological response in HCV-1 and HCV-2 infected patients. GNB1 may play an important role in activating the antiviral response prior to treatment. PMID: 23171003
    11. WDR26 is a novel Gbetagamma-binding protein that is required for the efficacy of Gbetagamma signaling and leukocyte migration PMID: 22065575
    12. Gbetagamma inhibits Epac-induced Ca 2+ elevation in melanoma cells. Cross talk of Ca 2+ signaling between Gbetagamma & Epac plays a major role in melanoma cell migration. PMID: 21679469
    13. Data implicate the domain I-II linker region as an important contributor to voltage dependent Gbeta1/Ggamma2 modulation of Cav2.2 calcium channels. PMID: 20181083
    14. Gbetagamma subunits enter in a protein complex with activated Rap1a and its effector Radil; this complex is required downstream of receptor stimulation for the activation of integrins and the positive modulation of cell-matrix adhesiveness. PMID: 20048162
    15. Directional sensing requires GNB1-mediated PAK1 and PIX alpha-dependent activation of Cdc42. PMID: 12887923
    16. Data show that G protein inhibition of N-type calcium channels is critically dependent on two separate but adjacent approximately 20-amino acid regions of the Gbeta subunit, as examined with Gbetas 1 and 5 and Ggamma2. PMID: 15105422
    17. G betagamma binds HDAC5 and inhibits its transcriptional co-repression activity PMID: 16221676
    18. HSD-3.8 (SPAG1), interacts with G-protein beta 1 subunit and activates extracellular signal-regulated kinases 1 and 2 PMID: 16368546
    19. G protein betagamma subunits stimulate type V and VI adenylyl cyclases PMID: 17110384
    20. No likely pathogenic GNB1 mutations have been found in any of 185 unrelated patients with autosomal dominant retinitis pigmentosa. PMID: 17167406
    21. While digenic disease with the SP4 Asn306Ser and the GNB1 intronic variant alleles has not been established, neither has it been ruled out. This leaves open the possibility of a cooperative involvement of SP4 and GNB1 in the normal function of the retina. PMID: 17356515
    22. Fission of transport carriers at the trans-Golgi network is dependent on specifically PLCbeta3, which is necessary to activate PKCeta and PKD in that Golgi compartment, via diacylglycerol production. PMID: 17492941
    23. Gbetagamma mediates UVB-induced human keratinocyte apoptosis by augmenting the ectodomain shedding of HB-EGF, which sequentially activates EGFR and p38 PMID: 17548351
    24. signaling pathway by which G(i)-coupled receptor specifically induces Rac and Cdc42 activation through direct interaction of Gbetagamma with FLJ00018. PMID: 18045877
    25. RACK1 regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC beta and PI3K gamma PMID: 18596232
    26. Results identify novel functions of beta-arrestin1 in binding to the beta1gamma2 subunits of heterotrimeric G-proteins and promoting G(betagamma)-mediated Akt signalling for NF-kappaB activation. PMID: 18729826
    27. Strong candidate gene for severe retinitis pigmentosa, RP32 (human 1p34.3-p13.3). Conclusion is based on a massive expression data set for mouse (103 strains) and joint analysis of RetNet database. PMID: 19727342

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Mental retardation, autosomal dominant 42 (MRD42)
  • 蛋白家族:
    WD repeat G protein beta family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4396

    OMIM: 139380

    KEGG: hsa:2782

    STRING: 9606.ENSP00000367869

    UniGene: Hs.430425



主站蜘蛛池模板: 欧美熟妇性xxxx交潮喷| 熟妇人妻中文av无码| 久久香蕉国产线看观看怡红院妓院| 乱色精品无码一区二区国产盗| 亚洲人av高清无码| 2012中文字幕在线视频| 人妻熟女av一区二区三区| 国产一卡2卡3卡四卡精品国色无边 | 大陆极品少妇内射aaaaa| 任我撸在线视频| 粉嫩被粗大进进出出视频| 国内精品久久久久影院优| 久久精品国产亚洲αv忘忧草| 亚洲乱妇老熟女爽到高潮的片| 亚洲精品电影院| 国厂精品114福利电影免费| 亚洲乱色熟女一区二区三区丝袜| 妺妺窝人体色www在线下载| 久久亚洲精品无码网站| 日本少妇三级hd激情在线观看 | 国产午夜av秒播在线观看| 国产极品粉嫩福利姬萌白酱| 亚洲人成人网站色www| 日日碰狠狠躁久久躁96| 无遮挡18禁啪啪免费观看| 影音先锋男人av鲁色资源网| 人妻少妇精品中文字幕av| 亚洲欧美日韩综合在线一| 亚洲男人综合久久综合天堂| 中文字幕乱码在线人视频| 在厨房拨开内裤进入毛片| 四虎永久免费地址入口| 国产v片在线播放免费无遮挡| 国产午夜成人免费看片app | 国产日韩制服丝袜第一页| 免费国产高清在线精品一区| 久久国产欧美日韩精品| 国产有奶水哺乳期无码avav| 亚洲国产成人综合在线不卡| 国语自产少妇精品视频| 99精品国产兔费观看久久99|