在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GNAT3 Antibody, Biotin conjugated

  • 中文名稱:
    GNAT3兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào):
    CSB-PA009600LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) GNAT3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    GNAT3
  • 別名:
    GDCA antibody; Ggust antibody; Gnat 3 antibody; GNAT3 antibody; GNAT3_HUMAN antibody; Gtn antibody; Guanine nucleotide binding protein alpha transducing 3 antibody; Guanine nucleotide binding protein G(t) subunit alpha 3 antibody; Guanine nucleotide-binding protein G(t) subunit alpha-3 antibody; Gustducin alpha 3 antibody; Gustducin alpha 3 chain antibody; Gustducin alpha-3 chain antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Guanine nucleotide-binding protein G(t) subunit alpha-3 protein (2-354AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.
  • 基因功能參考文獻(xiàn):
    1. (GNAT3, 11 SNPs) gene, located within the 1-LOD support interval region for their association with MS and its related traits. Several SNPs were associated with MS and its related traits. Remarkably. PMID: 22456541
    2. The sweet taste receptors (alpha-gustducin and T1R3) are involved in glucose-stimulated secretion of GLP-1 and PYY. PMID: 21324568
    3. Observational study of gene-disease association. (HuGE Navigator) PMID: 20858777
    4. Observational study of gene-disease association. (HuGE Navigator) PMID: 20660057
    5. the alpha-subunit of the taste-specific G protein gustducin is expressed prominently in cells of the human colon PMID: 16728727
    6. Axonemal-associated localization within the midpiece and principal piece of human spermatozoa raises the possibility that this G protein alpha-subunit may process intracellular signals controlling sperm motility. PMID: 17021831

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm. Note=Dual distribution pattern; plasmalemmal pattern with apical region localization and cytosolic pattern with localization throughout the cytoplasm.
  • 蛋白家族:
    G-alpha family, G(i/o/t/z) subfamily
  • 組織特異性:
    Expressed in taste buds (sensory organs of clustered epithelial cells) of the circumvallate and foliate papillae of the tongue at protein level. Expressed in enteroendocrine L cells of the gut. Detected also in spermatozoa.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 22800

    OMIM: 139395

    KEGG: hsa:346562

    STRING: 9606.ENSP00000381339

    UniGene: Hs.335049



主站蜘蛛池模板: 亚洲国产av导航第一福利网| 欧美兽交xxxx×视频| 疯狂迎合进入强壮公的视频| 午夜三级a三级三点在线观看| 亚洲一区二区三区影院| 人人人妻人人澡人人爽欧美一区| 免费又黄又爽1000禁片| 国产午夜aaaaa片在线影院| 超碰97人人让你爽| 三级男人添奶爽爽爽视频| www国产精品内射熟女| 中文字幕第一区高清av| 极品无码av国模在线观看| 99亚洲精品自拍av成人| 国产人妖视频一区二区| 高潮又爽又无遮挡又免费| 永久免费毛片在线播放| 欧美高清大屁股xxxxx| 免费无码又爽又刺激高潮的视频| 毛茸茸性xxxx毛茸茸毛茸茸| 国产老熟女老女人老人| 女人被狂躁高潮啊的视频在线看| 欧美黑人乱大交| 久久综合久久鬼色| 国产精品高潮露脸在线观看| 午夜男女刺激爽爽影院| 麻豆av福利av久久av| 亚洲国产av玩弄放荡人妇| 国偷自产一区二区三区在线视频| 性高朝久久久久久久久久| 欧美性猛交xxxx免费看蜜桃| 欧美成人一区二区三区在线视频| 国产成人精品一区二区视频| 亚洲欧洲日韩综合久久| 精品人妻av一区二区三区| 中文字幕熟妇人妻在线视频| 国产sp调教打屁股视频网站| 性按摩玩人妻hd中文字幕| 亚洲日韩国产二区无码| 成年片色大黄全免费网站久久| 天堂网在线观看|