在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GNAT3 Antibody, Biotin conjugated

  • 中文名稱:
    GNAT3兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào):
    CSB-PA009600LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) GNAT3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    GNAT3
  • 別名:
    GDCA antibody; Ggust antibody; Gnat 3 antibody; GNAT3 antibody; GNAT3_HUMAN antibody; Gtn antibody; Guanine nucleotide binding protein alpha transducing 3 antibody; Guanine nucleotide binding protein G(t) subunit alpha 3 antibody; Guanine nucleotide-binding protein G(t) subunit alpha-3 antibody; Gustducin alpha 3 antibody; Gustducin alpha 3 chain antibody; Gustducin alpha-3 chain antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Guanine nucleotide-binding protein G(t) subunit alpha-3 protein (2-354AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.
  • 基因功能參考文獻(xiàn):
    1. (GNAT3, 11 SNPs) gene, located within the 1-LOD support interval region for their association with MS and its related traits. Several SNPs were associated with MS and its related traits. Remarkably. PMID: 22456541
    2. The sweet taste receptors (alpha-gustducin and T1R3) are involved in glucose-stimulated secretion of GLP-1 and PYY. PMID: 21324568
    3. Observational study of gene-disease association. (HuGE Navigator) PMID: 20858777
    4. Observational study of gene-disease association. (HuGE Navigator) PMID: 20660057
    5. the alpha-subunit of the taste-specific G protein gustducin is expressed prominently in cells of the human colon PMID: 16728727
    6. Axonemal-associated localization within the midpiece and principal piece of human spermatozoa raises the possibility that this G protein alpha-subunit may process intracellular signals controlling sperm motility. PMID: 17021831

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm. Note=Dual distribution pattern; plasmalemmal pattern with apical region localization and cytosolic pattern with localization throughout the cytoplasm.
  • 蛋白家族:
    G-alpha family, G(i/o/t/z) subfamily
  • 組織特異性:
    Expressed in taste buds (sensory organs of clustered epithelial cells) of the circumvallate and foliate papillae of the tongue at protein level. Expressed in enteroendocrine L cells of the gut. Detected also in spermatozoa.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 22800

    OMIM: 139395

    KEGG: hsa:346562

    STRING: 9606.ENSP00000381339

    UniGene: Hs.335049



主站蜘蛛池模板: 久久se精品一区二区三区| 色偷拍 自怕 亚洲 10p| 久久亚洲国产精品亚洲老地址| 色94色欧美sute亚洲线路一| 99久久人人爽亚洲精品美女| 日日碰狠狠躁久久躁蜜桃| 无码中文av有码中文a| 好吊射视频988gaocom| 无码乱人伦一区二区亚洲| 中文字幕av一区二区三区人妻少妇| 久久夜色撩人精品国产小说| 猫咪免费人成网站在线观看 | 色噜噜狠狠狠狠色综合久一| 免费人成视频在线| 亚洲精品欧美综合一区二区| 无遮18禁在线永久免费观看挡| 再深点灬舒服灬太大了网站| 国产97在线 | 日韩| 中字幕视频在线永久在线| 色欲网天天无码av| 国产精品ⅴ无码大片在线看| 九九影院午夜理论片少妇| 少妇人妻精品无码专区视频| 搡女人真爽免费视频大全| 亚洲熟女综合一区二区三区| 国产免费爽爽视频在线观看| 欧美性xxxxx极品少妇直播| 自拍偷在线精品自拍偷无码专区| 久久婷婷五月综合色首页| 国产一区视频一区欧美| 中文字幕乱码亚洲无线三区 | 中文字幕人妻熟女人妻a片| 色偷偷偷久久伊人大杳蕉| 屁屁影院ccyy备用地址| 久久综合丝袜日本网| 综合精品欧美日韩国产在线| 中文毛片无遮挡高潮免费| 国产免国产免‘费| 日本真人边吃奶边做爽动态图 | 久久人妻xunleige无码 | 欧美老熟妇videos极品另类|