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GNAT2 Antibody

  • 中文名稱:
    GNAT2兔多克隆抗體
  • 貨號:
    CSB-PA008888
  • 規(guī)格:
    ¥1090
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    GNAT2
  • 別名:
    ACHM4 antibody; Cone type transducin alpha subunit antibody; GNAT 2 antibody; GNAT C antibody; Gnat2 antibody; GNAT2_HUMAN antibody; GNATC antibody; Guanine nucleotide binding protein (G protein) alpha transducing activity polypeptide 2 antibody; Guanine nucleotide binding protein G t subunit alpha 2 antibody; Guanine nucleotide-binding protein G(t) subunit alpha-2 antibody; Transducin alpha 2 antibody; Transducin alpha-2 chain antibody; Transducin alpha2 antibody; Transducin cone specific alpha polypeptide antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the N-terminal region of Human Gα t2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
  • 基因功能參考文獻:
    1. The majority (n = 12) of patients were either homozygotes or compound heterozygotes for known achromatopsia alleles, two in CNGB3 (p.T383fsX and p.T296YfsX9) and three in CNGA3 (p.R283Q, p.R427C and p.L527R). PMID: 23362848
    2. Single nucleotide polymorphisms in GNAT2 gene is associated with obesity. PMID: 23563607
    3. Missense mutations, nonsense mutations, splice mutations, and small deletions and insertions in the affected genes cause achromatopsia. PMID: 21267001
    4. Expression of GNAT2 transgene, when found in rod photoreceptor cells rather than in cones, demonstrates different mechanisms of amplification in the body's G-protein alpha cascades and the activation of phosphodiesterase 6. PMID: 20603337
    5. Clinical and genetic investigation of a large Tunisian family with complete achromatopsia: identification of a new nonsense mutation in GNAT2 gene. PMID: 21107338
    6. mutations in GNAT2 are implicated in achromatopsia PMID: 12077706
    7. We detected a deletion of a highly conserved lysine at codon 270 in a critical functional area of the alpha-cone transducin molecule, and therefore is not the disease causing mutation. PMID: 15094710

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  • 相關(guān)疾病:
    Achromatopsia 4 (ACHM4)
  • 亞細胞定位:
    Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment.
  • 蛋白家族:
    G-alpha family, G(i/o/t/z) subfamily
  • 組織特異性:
    Retinal rod outer segment.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4394

    OMIM: 139340

    KEGG: hsa:2780

    STRING: 9606.ENSP00000251337

    UniGene: Hs.36973



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